Patents by Inventor Alan Furlan

Alan Furlan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10393659
    Abstract: The present disclosure provides an instrument and methods for detecting an analyte, comprising a light source capable of generating excitation light for exciting a plurality of luminescence labels, an excitation beam path extending between said light source and said analyte, a detector capable of detecting light emitted from said luminescence label, an emission beam path extending between said analyte and said detector, a filter carrier carrying two or more pairs of filter portions, each pair being related to one luminescence label and comprising a first filter portion for transmitting excitation light and a second filter portion for transmitting emitted light, wherein said first filter portion of one pair is said second filter portion of another pair, and wherein said filter portions are arranged in a manner that a respective one of said pairs can be brought in an operative condition in which said first filter portion is in said excitation beam path and said second filter portion is in said emission beam pat
    Type: Grant
    Filed: September 15, 2016
    Date of Patent: August 27, 2019
    Assignee: Roche Molecular Systems, Inc.
    Inventor: Alan Furlan
  • Publication number: 20180135103
    Abstract: The present disclosure relates to methods for determining the amount or concentration of a nucleic acid of interest in an unprocessed sample by analyzing a processed sample and a reference sample with digital polymerase chain reaction (dPCR).
    Type: Application
    Filed: September 21, 2017
    Publication date: May 17, 2018
    Applicant: Roche Molecular System, Inc.
    Inventors: Alan Furlan, Michael Zeder
  • Publication number: 20180087090
    Abstract: The present disclosure relates to a method for reducing quantification errors caused by reaction volume deviations in digital polymerase chain reaction (dPCR) and to a method for determining the amount or concentration of a nucleic acid of interest in a sample with dPCR.
    Type: Application
    Filed: September 22, 2017
    Publication date: March 29, 2018
    Applicant: Roche Molecular System, Inc.
    Inventor: Alan Furlan
  • Publication number: 20170082543
    Abstract: The present disclosure provides an instrument and methods for detecting an analyte, comprising a light source capable of generating excitation light for exciting a plurality of luminescence labels, an excitation beam path extending between said light source and said analyte, a detector capable of detecting light emitted from said luminescence label, an emission beam path extending between said analyte and said detector, a filter carrier carrying two or more pairs of filter portions, each pair being related to one luminescence label and comprising a first filter portion for transmitting excitation light and a second filter portion for transmitting emitted light, wherein said first filter portion of one pair is said second filter portion of another pair, and wherein said filter portions are arranged in a manner that a respective one of said pairs can be brought in an operative condition in which said first filter portion is in said excitation beam path and said second filter portion is in said emission beam pat
    Type: Application
    Filed: September 15, 2016
    Publication date: March 23, 2017
    Inventor: Alan Furlan
  • Patent number: 9506865
    Abstract: An instrument is disclosed with a lens system including an objective lens system. The objective lens system is disposed between a light source and the plurality of reaction regions. The objective lens system includes a field lens array, and a pupil plane, wherein the pupil plane and the light source are located on opposite sides of the field lens array.
    Type: Grant
    Filed: July 30, 2013
    Date of Patent: November 29, 2016
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Alan Furlan, Joachim Wietzorrek
  • Patent number: 9482613
    Abstract: The present disclosure provides instruments and methods for detecting an analyte which are capable of exciting a plurality of luminescence labels and detecting light emitted therefrom. The instrument includes a filter carrier adapted for carrying a plurality of filter portion pairs, each pair related to a luminescence label and comprising a first filter portion for transmitting excitation light, and a second filter portion for transmitting emitted light. The first filter portion of a pair comprises a second filter portion of another pair. Also, the filter portions are arranged such that a pair can be brought into an operative condition whereby a first filter portion is in the excitation beam path and a second filter portion is in the emission beam path. The filter carrier and beam paths may be moved with respect to each other by a moving mechanism so as to bring a pair into operative condition.
    Type: Grant
    Filed: May 16, 2012
    Date of Patent: November 1, 2016
    Assignee: Roche Molecular Systems, Inc.
    Inventor: Alan Furlan
  • Publication number: 20150219637
    Abstract: An analytical processing and detection device is described which comprises a rack capable of holding at least one reaction receptacle, at least one magnetic unit for exerting a magnetic field on at least one reaction receptacle comprising magnetic particles in a fluid, wherein said at least one magnetic unit is reversibly or irreversibly connected to said rack, and wherein said magnetic field causes the magnetic particles to be sequestered to the side walls of said at least one reaction receptacle, and a detection unit for detecting a signal in the fluid in said reaction receptacle.
    Type: Application
    Filed: February 5, 2015
    Publication date: August 6, 2015
    Inventors: Roman Egli, Alan Furlan, Sascha Roehrig
  • Publication number: 20140093948
    Abstract: A light source module for use in an analytical instrument for analyzing at least one sample is disclosed. The light source module includes at least one light-emitting diode and at least one light guiding rod adapted to guide and shape light emitted by the light-emitting diode. The light source module further includes at least one memory device. The memory device has stored therein at least one driving parameter set, for driving the light-emitting diode in such a way that desired emission properties of light provided by the light source module are generated.
    Type: Application
    Filed: September 30, 2013
    Publication date: April 3, 2014
    Applicant: Roche Molecular Systems, Inc.
    Inventors: Fabian Durrer, Alan Furlan, Joachim Wietzorrek
  • Publication number: 20140038190
    Abstract: An instrument is disclosed with a lens system including an objective lens system. The objective lens system is disposed between a light source and the plurality of reaction regions. The objective lens system includes a field lens array, and a pupil plane, wherein the pupil plane and the light source are located on opposite sides of the field lens array.
    Type: Application
    Filed: July 30, 2013
    Publication date: February 6, 2014
    Inventors: Alan Furlan, Joachim Wietzorrek
  • Publication number: 20120295268
    Abstract: The present disclosure provides instruments and methods for detecting an analyte which are capable of exciting a plurality of luminescence labels and detecting light emitted therefrom. The instrument includes a filter carrier adapted for carrying a plurality of filter portion pairs, each pair related to a luminescence label and comprising a first filter portion for transmitting excitation light, and a second filter portion for transmitting emitted light. The first filter portion of a pair comprises a second filter portion of another pair. Also, the filter portions are arranged such that a pair can be brought into an operative condition whereby a first filter portion is in the excitation beam path and a second filter portion is in the emission beam path. The filter carrier and beam paths may be moved with respect to each other by a moving mechanism so as to bring a pair into operative condition.
    Type: Application
    Filed: May 16, 2012
    Publication date: November 22, 2012
    Applicant: ROCHE DIAGNOSTICS OPERATIONS, INC.
    Inventor: Alan Furlan
  • Patent number: 7906767
    Abstract: The invention concerns an optical instrument for imaging fluorescence signals from an arrangement of a plurality of individual detection sites, for example the wells of a microtitre plate. In order to improve the light yield of the fluorescence excitation with excitation light as well as the light yield of the detection of the fluorescence signals, an objective array is provided which is arranged in the beam path between the field lens and the detection sites and comprises a field lens array with field lens array elements and a pupil lens array with pupil lens array elements. In order to improve the channel separation and suppress interfering light the objective array can comprise a diaphragm array with in each case two diaphragm openings per detection site.
    Type: Grant
    Filed: July 21, 2009
    Date of Patent: March 15, 2011
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Alan Furlan, Joachim Wietzorrek
  • Publication number: 20100091273
    Abstract: The present invention relates to a system for the optical detection of light from analytical samples, the system comprising an analytical instrument comprising an optical detection unit and a sample block unit for receiving a plurality of analytical samples, the system further comprising a calibration device for calibrating the optical detection unit of the analytical instrument, wherein the calibration device comprises a substrate and at least one electrically powered reference light source coupled to the substrate, said at least one reference light source emitting light being detected by the optical detection unit.
    Type: Application
    Filed: April 8, 2009
    Publication date: April 15, 2010
    Applicant: ROCHE MOLECULAR SYSTEM, INC.
    Inventors: Roman EGLI, Alan FURLAN, Mario CURCIO
  • Publication number: 20100092956
    Abstract: An analytical processing and detection device is described which comprises a rack capable of holding at least one reaction receptacle, at least one magnetic unit for exerting a magnetic field on at least one reaction receptacle comprising magnetic particles in a fluid, wherein said at least one magnetic unit is reversibly or irreversibly connected to said rack, and wherein said magnetic field causes the magnetic particles to be sequestered to the side walls of said at least one reaction receptacle, and a detection unit for detecting a signal in the fluid in said reaction receptacle.
    Type: Application
    Filed: April 7, 2009
    Publication date: April 15, 2010
    Applicant: ROCHE MOLECULAR SYSTEMS, INC.
    Inventors: Roman Egli, Alan Furlan, Sascha Roehrig
  • Publication number: 20100019157
    Abstract: The invention concerns an optical instrument for imaging fluorescence signals from an arrangement of a plurality of individual detection sites, for example the wells of a microtitre plate. In order to improve the light yield of the fluorescence excitation with excitation light as well as the light yield of the detection of the fluorescence signals, an objective array is provided which is arranged in the beam path between the field lens and the detection sites and comprises a field lens array with field lens array elements and a pupil lens array with pupil lens array elements. In order to improve the channel separation and suppress interfering light the objective array can comprise a diaphragm array with in each case two diaphragm openings per detection site.
    Type: Application
    Filed: July 21, 2009
    Publication date: January 28, 2010
    Applicant: ROCHE MOLECULAR SYSTEMS, INC.
    Inventors: Alan Furlan, Joachim Wietzorrek