Abstract: Novel methods of classifying subjects as candidates for treatment with agent that inhibits or kills cancer associated mesenchymal cells, tumor initiating cancer cells, or cancer stem cells treatment and subsequent administration of the agent that inhibits or kills cancer associated mesenchymal cells, tumor initiating cancer cells, or cancer stem cells are disclosed within.

Abstract: Novel methods of classifying subjects as candidates for treatment with a cancer associated mesenchymal cell, tumor initiating cancer cell, or cancer stem cell inhibitor treatment and subsequent administration of the cancer associated mesenchymal cell, tumor initiating cancer cell, or cancer stem cell inhibitor are disclosed within.

Abstract: A code signal representing a sequence of code symbols carrying digital information is generated with the frequency components of the code signal being essentially confined to a preselected signalling band lying within the bandwidth of an audio signal within which the code signal is to be embedded. The audio signal is continuously frequency analyzed over a frequency band encompassing the signalling band and the code signal is dynamically filtered as a function of the analysis thereby to provide a modified code signal with frequency components which are, at each time instant, essentially a preselected small proportion of the levels of the corresponding audio signal frequency components. Accordingly, the modified code signal can be combined with the audio signal to obtain a composite audio signal which is not readily distinguishable from the original audio signal by listening.