Abstract: Compositions, including those in which the active ingredient or agent is stable and capable of penetrating the sites of topical application are provided. The compositions can include a macromolecule, for example, a parathyroid hormone (PTH), a PTH-like hypercalcemic factor (CFF) or biologically active variant of a PTH or CFF in a vehicle comprising a polymer or cationic liposome. The compositions can also include other substances that further promote the stability of the active agent (e.g., buffers, antioxidants or carbohydrates). Also provided are methods for using the compositions for treatment of skin disorders (e.g., hyperproliferative skin disorders, including, but not limited to, for example, psoriasis, acne, rosacea or acne.