Abstract: Disclosed herein is a biosafety enclosure for protecting occupants of a vehicle from pathogens. In one example, the biosafety enclosure comprises a protective cover member made of a durable material shaped to form a three-dimensional structure that is installed inside of the vehicle and isolates the one or more occupants of the biosafety enclosure from other occupants of the vehicle. The biosafety enclosure comprises a plurality of connectors attached to the protective cover member in order to secure the protective cover member inside the vehicle. In addition, the biosafety enclosure comprises one or more air circulation vents disposed within the protective cover member, wherein an air circulation vent is connectable to an external air filtration device or an air filtration system of the vehicle. The biosafety enclosure also comprises an ingress/egress member comprised in the protective cover member to allow entry/exit of occupants to/from the enclosure.