Abstract: The present invention relates to Huwentoxin-IV variants, polynucleotides encoding them, methods of making and using the foregoing, and methods of alleviating pain with peptide inhibitors of Nav1.7.

Abstract: The present invention relates to Huwentoxin-IV variants, polynucleotides encoding them, and methods of making and using the foregoing.

Abstract: The present invention relates to Huwentoxin-IV variants, polynucleotides encoding them, methods of making and using the foregoing, and methods of alleviating pain with peptide inhibitors of Nav1.7.

Abstract: The present invention relates to Huwentoxin-IV variants, polynucleotides encoding them, and methods of making and using the foregoing.

Abstract: The present invention provides, with reference to FIG. 1, an amphibian for use in land and marine modes comprising: a planing hull; three wheel stations, two of the three wheel stations being front wheel stations provided one on each side of and in the front half of the amphibian, and the third wheel station being a rear wheel station provided in a central region in the rear half of the amphibian; at least one wheel provided at each wheel station, each wheel being movable between a protracted land mode position and a retracted marine mode position; land propulsion means to propel the amphibian on land in the land mode, the land propulsion means comprising at least one of the wheels; and marine propulsion means to propel the amphibian on water in the marine mode, the marine propulsion means comprising at least two impellers or propellers provided one on each side of the rear wheel station.

Abstract: 6-[(4,5-Dihydro-1H-imidazol-2-yl)amino-]-7-methyl-1H-benzimidazole-4-carbonitrile substantially free of 2,3,7-triamino-4,6-dimethyl-1,9-phenazinedicarbonitrile, and the anhydrous monoacetate salt thereof, are useful in the treatment of alpha-2 mediated disorders such as ocular hypertension.

Abstract: Amphibious vehicle needs less power on land than on water. A control system is provided to limit power and/or speed on land, using: restriction of flow of fuel, air, or exhaust gases; heated intake air; exhaust gas recirculation; declutching of a supercharger; bypassing of a turbocharger; a variable throttle stop, dual throttles, or a switchable throttle damper; cylinder or intake valve deactivation; a dual length intake manifold; dual mode ignition or engine mapping; dual fuel—gasoline on water, compressed natural gas on road; variable compression ratios or valve timing; a clutch designed to slip; automatic brake application; or aerodynamic brakes. The suspension may tilt the vehicle to increase aerodynamic resistance. The road transmission may be geared to limit maximum speed. High rolling resistance tyres or twin engines may be used. A sensor on retractable suspension may indicate whether the vehicle is on land or on water.

Abstract: Amphibious vehicle (50), with reference to FIG. 4, has jet drive (30) packaged behind power train (20, 22), but also configured to produce sufficient thrust for planing, despite drag created by open arches around retractable wheels (52). The ratio of thrust to jet intake length is at least 18 kN/m. The ratio of fluid inlet area to fluid outlet area may be between (2.5) and (3.5). The rate of fluid flow through the jet may be 0 to 1.5 m3/sec. The maximum thrust may be 7700N, from an engine peak power of less than 135 kW, with a jet less than 860 mm long. The jet drive shaft may be skewed laterally; and may be cantilevered from a bearing in the conduit wall; which bearing may be rotated when the vehicle is driven on roads. Water flow through the jet may be reversible; alternatively, a reversing bucket may be fitted.

Abstract: Amphibious vehicle (10), with reference to FIG. 1, which may plane on water, has a propulsion system comprising prime mover (20), power transmission means (30), marine propulsion means (40), and land propulsion means (50). Vehicle (10) is operable in marine mode or land mode. Common controls are used on land and water, the steering control travel may be the same in each mode. Power is transmitted to the marine propulsion means in marine mode; and to both marine and land propulsion means in land mode. The power transmission ratio between land and marine propulsion means may be variable in land mode. The propulsion control means (60) may comprise electronic processing means and/or electrical, mechanical, hydraulic, or electromechanical actuation devices, or any combination thereof. Prime mover (20) may comprise an internal combustion engine; an electric motor, a fuel cell; a hybrid engine; or any combination thereof. The transmission means may be mechanical, electric, or hydraulic.

Abstract: An amphibious vehicle has retractable wheels (2, 3) attached to hubs (2), and a planing hull (10, 11, 3). Front wheels are arranged to be steered by a power assisted transversely mounted element (16), which may be a rack and pinion unit. The element may be linked to the wheels by links (14, 14?), which fold up to position (14?) when the wheels are retracted. Actuating rod (28) is mounted to said element, and arranged for transverse movement. A flexible coupling means, such as cable (34) and sleeve (36), connects rod (28) to a steerable part (42, 4) of a marine propulsion unit, to effect marine steering. Road and marine steering may be operable simultaneously. More than one front steered axle, and/or marine propulsion unit, may be fitted. The steering system is readily adapted to all kinds of power assisted steering, and also to “steer by wire”.

Abstract: A sit-stride amphibious vehicle configuration which supports a high performance envelope both on land as well as in water. The vehicle has a planing hull and four retractable wheels. Handlebars provide for directional control in both modes of operation. Each road wheel is retractable by pivoting through at least 45° so as to maximize ground clearance when in the land mode of operation and to minimize drag at substantial lean angles when in the marine mode of operation. While a jet drive may remain directly connected to the engine at all times, the drive wheels are only connected during land mode via a speed-change transmission. The entire power train is supported by a frame that is separable from the hull which in turn has a detachable top deck portion, whereby such configuration simplifies the construction, repair and servicing of the vehicle.

Abstract: A planing amphibious vehicle with retractable wheels and a sit-astride seat having dimensions that impart enhanced capability in both land as well as water modes of operation. The beam, track, dead rise angle and the location of the handlebars cooperate to enhance freeboard and ground clearance without sacrificing manoeuvrability. The length is at least 2400 mm; the beam is at least 1250 mm; the deadrise angle at least 10°; and the handlebars are located only slightly forward of the halfway distance from transom to bow.

Abstract: An amphibious vehicle wheel suspension includes upper and lower linkages, road suspension means, and a retraction means for moving the wheel between a protracted position for road use and a retracted position for marine use. Suspension means can be operatively disconnected from the wheel and/or the linkages to allow for retraction and protraction. Retraction means may also be disconnected for road use. The disconnection mechanisms may comprise a ball and track mechanism, interlocking splines, interlocking teeth, or a pneumatic clutch. Also provided is a combination of splines for a suspension lever arm, and a pneumatic clutch for retraction arm Suspension means may be connected to upper linkage. Coil, torsion bar, or hydropneumatic springs may be used.

Abstract: An amphibious vehicle has a power train including an engine having an oil sump connected to a lower portion of the engine an in-line transmission and a power take off. The power take off is located between the engine and the transmission thereby separating the engine and the transmission, is driven by the engine crankshaft and drives the transmission; and is adapted to transfer drive to a marine propulsion unit located at the rear of the amphibious vehicle by means of a drive shaft which runs below or through the oil sump of the engine or alongside the engine. The output from the transmission is adapted by a transfer drive to drive a differential located at the rear of the amphibious vehicle; and optionally also to drive a front differential, to provide all-wheel-drive The vehicle may have a vee-type hull or a cathedral type hull; and may comprise retractable suspension, with angled retraction.

Abstract: Planing amphibious vehicle (101) comprises engine (105) with internal cooling ducts (106). The engine is cooled first by air-water exchanger (102), and secondly by water-water exchanger (108). One or both exchangers may be located in compartment (119), separated from engine compartment (117) fully by bulkhead (80) (FIG. 4), or partially by bulkheads (118, 120). External water for exchanger (108) is drawn in from outside hull (109) through jet intake (114), the through inlet (115) in jet drive duct (116); and exhausted through outlet (123). Compartment (119) may also contain exhaust silencer (121). Numerals (103 and 104) denote grilles; (107) denotes cooling fan(s). FIG. 2 shows an alternative arrangement, with external water drawn from beneath the hull by pump (32). FIG. 1 shows front mounted radiator (2), covered by external flap (4) allowing air cooling to be shut down on water. FIG. 3 shows a water-water exchanger combined with the marine jet drive.

Abstract: Power train has an engine, transmission, water jet, and sandwich power take off. The power take off output shaft is enclosed by chain case, and drives shaft, which runs below or alongside engine oil sump; or through the sump in a tunnel or recess. A decoupler may be provided in the marine drive. Transfer case transfers drive power from transmission to output shaft, which drives drive shaft and rear wheel differential. Four-wheel drive may be provided, with additional forward drive shaft and differential. A center differential may be provided in or adjacent to the transfer case; transmission may be manual, sequential shift, semi-automatic, automatic, or a continuously variable transmission. The marine drive may be a jet drive, as shown, or a screw propeller, or other marine propulsion means.

Abstract: 6-[(4,5-Dihydro-1H-imidazol-2-yl)amino-]-7-methyl-1H-benzimidazole-4-carbonitrile substantially free of 2,3,7-triamino-4,6-dimethyl-1,9-phenazinedicarbonitrile, and the anhydrous monoacetate salt thereof, are useful in the treatment of alpha-2 mediated disorders such as ocular hypertension.