Abstract: Anti-human CD40L antibodies engineered to lack the ability to activate platelets and methods for treating patients having a CD40L-associated disease.

Abstract: The present disclosure relates to the use of CuPTSM in methods and compositions for treating subjects with a neurodegenerative disease. Subjects with a neurodegenerative disease can have, e.g., amyotrophic lateral sclerosis (ALS).

Abstract: Methods and therapeutic compositions are disclosed for treating neurological disorders, such as Amyotrophic Lateral Sclerosis (ALS), Alzheimer's disease, Parkinson's disease and/or Huntington's disease, using Salubrinal analogs, or pharmaceutically acceptable salts, hydrates, or solvates thereof.

Abstract: Methods and therapeutic compositions are disclosed for treating neurological disorders, such as Amyotrophic Lateral Sclerosis (ALS), Alzheimer's disease, Parkinson's disease and/or Huntington's disease, using Salubrinal analogs, or pharmaceutically acceptable salts, hydrates, or solvates thereof.

Abstract: Anti-human CD40L antibodies engineered to lack the ability to activate platelets and methods for treating patients having a CD40L-associated disease.

Abstract: The present disclosure relates to the use of CuPTSM in methods and compositions for treating subjects with a neurodegenerative disease. Subjects with a neurodegenerative disease can have, e.g., amyotrophic lateral sclerosis (ALS).

Abstract: Anti-human CD40L antibodies engineered to lack the ability to activate platelets and methods for treating patients having a CD40L-associated disease.

Abstract: Anti-human CD40L antibodies engineered to lack the ability to activate platelets and methods for treating patients having a CD40L-associated disease.

Abstract: The present disclosure relates to the use of CuPTSM in methods and compositions for treating subjects with a neurodegenerative disease. Subjects with a neurodegenerative disease can have, e.g., amyotrophic lateral sclerosis (ALS).

Abstract: Methods and therapeutic compositions are disclosed for treating neurological disorders, such as Amyotrophic Lateral Sclerosis (ALS), Alzheimer's disease, Parkinson's disease and/or Huntington's disease, using Salubrinal analogs, or pharmaceutically acceptable salts, hydrates, or solvates thereof.

Abstract: An apparatus including: a plurality of forming molds, each mold including: a leading edge; a trailing edge; a mold face; a plurality of first recesses in the mold face positioned across the mold face, each first recess in fluid communication with a first vacuum duct; a leading face extending from the leading edge in a direction away from the mold face; a trailing face extending from the trailing edge in a direction away from the mold face; wherein at least a portion of the leading face is recessed relative to the mold face proximal the leading edge or at least a portion of the trailing face is recessed relative to the mold face proximal the trailing edge; wherein the plurality of forming molds is arranged leading edge to trailing edge as a first mold belt.

Abstract: Anti-human CD40L antibodies engineered to lack the ability to activate platelets and methods for treating patients having a CD40L-associated disease.

Abstract: Anti-human CD40L antibodies engineered to lack the ability to activate platelets and methods for treating patients having a CD40L-associated disease.

Abstract: Anti-human CD40L antibodies engineered to lack the ability to activate platelets and methods for treating patients having a CD40L-associated disease.

Abstract: An apparatus including: a plurality of forming molds, each mold including: a leading edge; a trailing edge; a mold face; a plurality of first recesses in the mold face positioned across the mold face, each first recess in fluid communication with a first vacuum duct; a leading face extending from the leading edge in a direction away from the mold face; a trailing face extending from the trailing edge in a direction away from the mold face; wherein at least a portion of the leading face is recessed relative to the mold face proximal the leading edge or at least a portion of the trailing face is recessed relative to the mold face proximal the trailing edge; wherein the plurality of forming molds is arranged leading edge to trailing edge as a first mold belt.

Abstract: Anti-human CD40L antibodies engineered to lack the ability to activate platelets and methods for treating patients having a CD40L-associated disease.

Abstract: Aspects of the present disclosure involve methods and apparatuses for cutting and removing trim from an advancing substrate. Particular embodiments of the apparatuses and methods disclosed herein provide for removal of continuous lengths of trim, and in some embodiments, discrete pieces of trim from an advancing substrate.

Abstract: Anti-human CD40L antibodies engineered to lack the ability to activate platelets and methods for treating patients having a CD40L-associated disease.

Abstract: Methods and systems are disclosed for evaluating a neurological condition by employing at least one motion sensor, configured to be attached to a body appendage, a memory associated with the sensor(s) to periodically record movement data during periods of prescribed exercises; and a processor for analyzing changes in movement data over time to evaluate the progression of the neurological condition. In one embodiment, the neurological condition is ALS and at least four motion sensors are employed such that each arm and leg of the patient has an associated sensor. The sensors can be accelerometers that measure the displacement, velocity and acceleration of an associated limb during periods of prescribed exercise. For example, changes in the patient's ability to repeat a series of limb-lifting exercises or the measurement of limb tremors associated with the conduct of the exercises can be correlated with norms and analyzed to classify the stage of ALS in a patient and/or predict the rate of progression.

Abstract: A method of recirculating high temperature fuel used as a coolant and lubricant in the engine to a fuel state control system is provided. The method may decrease the need for a heater component in the fuel state control system. The combination of the fuel recirculation and the use of a fuel state control system may increase the engine efficiency and decrease the emission of pollutants.