Abstract: An intraocular lens is provided that includes an optic body having anterior and posterior walls, a chamber, and optically transmissive primary and secondary fluids, and method for making and using the same. The secondary fluid is substantially immiscible with the primary fluid and has a different density and a different refractive index than the primary fluid. The primary fluid is present in a sufficient amount that orienting optical body optical axis horizontally for far vision positions the optical axis through the primary fluid, thereby immersing the anterior and posterior optical centers in the primary fluid. The secondary fluid is contained in the optic body in a sufficient amount that orienting the optical axis over a range of effective downward angles relative to the horizontal for near vision positions the optical axis to extend through the primary fluid and the secondary fluid, thus changing the focus of the intraocular lens.

Abstract: An intraocular lens is provided that includes an optic body having anterior and posterior walls, a chamber, and optically transmissive primary and secondary fluids, and method for making and using the same. One of the fluids is a gas. The secondary fluid is substantially immiscible with the primary fluid and has a different density and a different refractive index than the primary fluid. The primary fluid is present in a sufficient amount that orienting optical body optical axis horizontally for far vision positions the optical axis through the primary fluid, thereby immersing the anterior and posterior optical centers in the primary fluid. The secondary fluid is contained in the optic body in a sufficient amount that orienting the optical axis over a range of effective downward angles relative to the horizontal for near vision positions the optical axis to extend through the primary fluid and the secondary fluid, thus changing the focus of the intraocular lens.

Abstract: An intraocular device including a prism and shift amplifier is provided. Also provided is a system containing the intraocular device, and a method for improving vision of a person with central vision loss. The method involves implanting the intraocular device in the person so that the prism and shift amplifier cumulatively shift a retinal image away from the fovea of an eye to a functional retinal portion of the eye. Also provided is a method for correcting a binocular misalignment of a person using the intraocular device.

Abstract: Methods and systems are provided for changing the appearance of eye color. The methods and systems generally comprise administering a biologically compatible molecule (preferably a coloring agent) coupled to an antibody to an eye of a subject, and binding the antibody to a structure, preferably the cornea of the eye.

Abstract: An intraocular lens and related method for optically altering an image peripheral to a scotomatous area in a visual field of a person having a retinal degenerative condition are provided. Also provided are an intraocular lens and related method for reducing the effect of a scotomous area in a visual field. The intraocular lens includes first and second fluids in an optic body.

Abstract: An intraocular lens is provided that includes an optic body having anterior and posterior walls, a chamber, and optically transmissive primary and secondary fluids, and method for making and using the same. The secondary fluid is substantially immiscible with the primary fluid and has a different density and a different refractive index than the primary fluid. The primary fluid is present in a sufficient amount that orienting optical body optical axis horizontally for far vision positions the optical axis through the primary fluid, thereby immersing the anterior and posterior optical centers in the primary fluid. The secondary fluid is contained in the optic body in a sufficient amount that orienting the optical axis over a range of effective downward angles relative to the horizontal for near vision positions the optical axis to extend through the primary fluid and the secondary fluid, thus changing the focus of the intraocular lens.