Abstract: The present invention discloses a method for preparing cabergoline form I by combining cabergoline and a solvent comprising ethylbenzene to form a solvate and obtaining form I from the solvate. Also disclosed in a method for preparing cabergoline form I by combining cabergoline and a first solvent to form a solution and additionally including a second solvent to the solution, followed by crystallization to form cabergoline form I. Further disclosed is a solvate form of cabergoline comprising cabergoline and ethylbenzene and, optionally, n-heptane.

Abstract: A sterilisable particle-size reduction apparatus, component parts thereof and a method of sterilising and validating sterility thereof are provided. Also provided is use thereof to prepare sterile suspensions of drugs.

Abstract: A method of preparing cabergoline Form I, comprising forming a solvate including cabergoline and 4-fluorotoluene or 1,3,5-trimethylbenzene and obtaining cabergoline Form I from the solvate. Another aspect of the present invention provides a method for preparing cabergoline Form I comprising dissolving cabergoline in 4-fluorotoluene or 1,3,5-trimethylbenzene and recovering the cabergoline Form 1 polymorph. Cabergoline Form I can then be obtained from the solution, suitably by direct crystallization of Form I or by recovery of a solvate which can be converted to Form I.

Abstract: A method of preparing cabergoline Form I, comprising forming a solvate including cabergoline and a p-disubstituted benzene of formula (A) or 1,3,5-trimethylbenzene and obtaining cabergoline Form I from the solvate. Another aspect of the present invention provides a method for preparing cabergoline Form I comprising dissolving cabergoline in p-disubstituted benzene or 1,3,5-trimethylbenzene and recovering the cabergoline Form I polymorph, suitably by direct crystallization of Form I or by recovery of a solvate which can be converted to Form I. Another aspect of the present invention provides a novel cabergoline polymorph designated cabergoline Form FB and a method of preparing said polymorph by dissolving or forming a solvate of cabergoline in fluorobenzene and recovering cabergoline Form FB.

Abstract: Disclosed is a process for the synthesis of 17?-hydroxy-7?-methyl-19-nor-17?-pregn-5(10)-ene-20-yne-3-one (ti-bolone, 11) and intermediates useful for the synthesis thereof: (11).

Abstract: A sterilisable particle-size reduction apparatus, component parts thereof and a method of sterilising and validating sterility thereof are provided. Also provided is use thereof to prepare sterile suspensions of drugs.

Abstract: Disclosed are processes for the synthesis and purification of prostaglandins and analogues thereof, especially analogues of PGF2?.

Abstract: Disclosed are processes for the synthesis and purification of prostaglandins and analogues thereof, especially analogues of PGF2?.

Abstract: The present invention discloses a method for preparing cabergoline form I by combining cabergoline and a solvent comprising ethylbenzene to form a solvate and obtaining form I from the solvate. Also disclosed in a method for preparing cabergoline form I by combining cabergoline and a first solvent to form a solution and additionally including a second solvent to the solution, followed by crystallization to form cabergoline form I. Further disclosed is a solvate form of cabergoline comprising cabergoline and ethylbenzene and, optionally, n-heptane.

Abstract: A sterile composition of a pharmaceutical compound is prepared by combining solvent with a non-sterile pharmaceutical compound to form a solution and filtering to yield a sterile pharmaceutical compound, optionally removing all or part of the solvent, and under sterile conditions combining the compound with a pharmaceutically acceptable carrier.

Abstract: ?9 THC acid is obtained from plant material and extracted into an aqueous solvent under conditions of pH control. The acid is converted to a salt and the salt extracted into a polar solvent, yielding acid of high purity. The ?9 THC acid is t5en converted to ?9 THC which is further purified and combined with a carrier for pharmaceutical use.

Abstract: ?9 THC acid is obtained from plant material and extracted into an aqueous solvent under conditions of pH control. The acid is converted to a salt and the salt extracted into a polar solvent, yielding acid of high purity. The ?9 THC acid is t5hen converted to ?9 THC which is further purified and combined with a carrier for pharmaceutical use.

Abstract: The present invention is concerned with an apparatus and method for removing a drive coupling component from an oil burner unit housing. A drive coupling comprises a first drive coupling end fitting disposed on an oil pump shaft, a second drive coupling end fitting disposed on a motor shaft and a drive coupling connector which connects the first and second drive coupling end fittings. The apparatus comprises a handle having a proximal and a distal end, a front wall contiguous with the distal end of said handle and including a proximal exterior surface and a distal interior surface. A receiver for receiving at least one drive coupling component is contiguous with the interior surface of the front wall. An engagement member, which engages a distal end of a second drive coupling end fitting, is contiguous with the distal end of the receiver.

Abstract: Making a tire mold by spraying molten atomized metal on a model to form a metal shell and then reinforcing the shell with a resin backing to form a mold segment for the tire mold. Modular shoe container assemblies have replaceable backing members for making different size molds and flat plate spacers for providing different thicknesses of the mold segment. In one embodiment a slide block is used for one side of the cavity whereby a sole plate is eliminated.

Abstract: Detaching a cured tire from mold sections of a tire mold during opening of the mold by communicating air under pressure into the space between the mold sections and confining the air in this space with a sleeve member supported on the upper mold section and slidably urged into sealing engagement with the lower mold section. Air under pressure is then communicated from the space between the mold sections to the spaces between the cured tire surface and the molding surfaces of the upper and lower mold sections to detach the tire. Sealing rings on the sleeve and on the upper mold section prevent leakage of the air under pressure from the space between the mold section. Spring means between the upper mold section and the sleeve member provide extension of the sleeve member into sealing engagement with the lower mold section.

Abstract: Injection molding a tread on an annular tire casing (44) positioned in a mold (10') by introducing a fluid molding compound (76',78') at high pressures and high temperatures into a tread molding space (105) through runner passages (114) extending from an edge (116) to a centerplane (20'--20') of the mold (10') and having gates (118) opening into the tread molding space (105). Alternatively the runner passages (56,58) may be defined by annular runner surfaces (60,62,64,66) in communication with the tread molding space (48) through annular gates (52,54). The fluid molding compound (76,78) may be ejected from annular transfer recesses (68,70) in the mold (10) by squeeze rings (84,86) movable into the transfer recesses (68,70) to introduce the fluid molding compound (76,78) into the runner passages (56,58).

Abstract: Injection molding a tread on an annular tire casing (44) positioned in a mold (10') by introducing a fluid molding compound (76',78') at high pressures and high temperatures into a tread molding space (105) through runner passages (114) extending from an edge (116) to a centerplane (20'--20') of the mold (10') and having gates (118) opening into the tread molding space (105). Alternatively the runner passages (56,58) may be defined by annular runner surfaces (60,62,64,66) in communication with the tread molding space (48) through annular gates (52,54). The fluid molding compound (76,78) may be ejected from annular transfer recesses (68,70) in the mold (10) by squeeze rings (84,86) movable into the transfer recesses (68,70) to introduce the fluid molding compound (76,78) into the runner passages (56,58).

Abstract: A duplex extruder head for receiving extrudate from each of two extruders to deliver a composite unitary extrudate such as tire tread stock has a cavity plug or vee-block insert secured in an open top channel-shaped receiver without bolts or hinges by a pair of slidable clamps. The head also has a transverse slot for slidably receiving a die assembly endwise into the slot. The die assembly is then elevated to operating position and securely clamped by a pair of wedge-like gibs. Clamping of either the insert or the die assembly is effected by hydraulic cylinder or equivalent means. The foregoing abstract is not to be taken as limiting the invention of this application, and in order to understand the full nature and extent of the technical disclosure of this application, reference must be made to the accompanying drawing and the following detailed description.

Abstract: A die clamp fixing an extruder final product profile die is secured relative to an extruder die head vertical front face and conveniently removed or interchanged. The die clamp swings about a horizontal pin to a horizontal position where the final die can be lifted freely from or placed on the clamp. The arrangement provides for a flow distributing insert readily removed or interchanged in like manner.