Abstract: Embodiments are directed to sharing namespaces across file system clusters. A file in a spoke file system may be determined based on a command provided to the spoke file system such that the file may be associated with an inode mask. Data blocks associated with the file may be determined based on the command and the inode mask such that the data blocks may be absent from the spoke file system. Requests for leases may be generated based on the absent data blocks such that each lease request corresponds to a portion of the absent data blocks Employing the leases provided by a hub file system to: copy the absent data blocks from the hub file system where each portion of absent data blocks may be associated with a lease; updating the inode mask to include the leases and each copied portion of absent blocks.

Abstract: According to examples, an apparatus may include a processor and a memory on which is stored machine-readable instructions that when executed by the processor, may cause the processor to identify configuration information to be used by an on-premise access management service to provide authentication services to applications by users. The processor may also transform the identified configuration information into a transformed set of configuration information to be used by a cloud-based access management service to provide authentication services to the applications by users. In addition, the processor may store the transformed set of configuration information for use by the cloud-based access management service to provide authentication services to the applications by users to migrate authentication of the users from the on-premise access management service to the cloud-based access management service.

Abstract: According to examples, an apparatus may include a processor and a memory on which is stored machine-readable instructions that when executed by the processor, may cause the processor to identify configuration information to be used by an on-premise access management service to provide authentication services to applications by users. The processor may also transform the identified configuration information into a transformed set of configuration information to be used by a cloud-based access management service to provide authentication services to the applications by users. In addition, the processor may store the transformed set of configuration information for use by the cloud-based access management service to provide authentication services to the applications by users to migrate authentication of the users from the on-premise access management service to the cloud-based access management service.

Abstract: Disclosed herein are methods of modifying properties of a cellulosic material, the method comprising: depositing an additive onto the cellulosic material, the additive being in a vapor phase and configured to modify one or more properties of the cellulosic material; and adsorbing the additive into the cellulosic material, wherein the additive reacts with one or more functional groups of the cellulosic material. The depositing can comprise an atomic layer deposition of the additive onto the cellulosic material. The additive can be configured to react with a nucleophile in the cellulosic material. The one or more properties of the cellulosic material can include: hydrophobicity, thermal conductivity, thermal diffusivity, fungo-toxicity, toxicity, wettability, tensile strength, corrosiveness, biodegradability, bio-toxicity, or swelling.

Abstract: The present invention provides inter alia methods for generating a library of cells producing polyketides and selecting for these strains based on binding to a protein target.

Abstract: The present invention provides a novel isolated succinate prodrug as the free compound or a salt, hydrate, solvate or complex thereof being cell permeable and aimed for increasing the ATP-production in mitochondria. The compound is useful in the medical treatment of a range of diseases, in nutritional supplements, nutricosmetics and in cosmetics.

Abstract: The present invention provides a novel isolated succinate prodrug as the free com-pound or a salt, hydrate, solvate or complex thereof being cell permeable and aimed for increasing the ATP-production in mitochondria. The compound is useful in the medical treatment of a range of diseases, in nutritional supplements, nutricosmetics and in cosmetics.

Abstract: An aircraft that includes a hybrid-electric propulsion system is provided. In one aspect, the hybrid-electric propulsion system includes at least one propulsor that includes a gas turbine engine and an electric machine mechanically coupled with a spool of the gas turbine engine. When idle operation is commanded, electrical power is provided to the electric machine to cause the electric machine to apply torque to the spool and fuel provided to the engine can be reduced. Thus, the electric machine is controlled to provide a power assist to maintain the engine at the commanded idle speed whilst reducing fuel consumption.

Abstract: According to examples, an apparatus may include a processor and a memory on which is stored machine-readable instructions that when executed by the processor, may cause the processor to identify configuration information to be used by an on-premise access management service to provide authentication services to applications by users. The processor may also transform the identified configuration information into a transformed set of configuration information to be used by a cloud-based access management service to provide authentication services to the applications by users. In addition, the processor may store the transformed set of configuration information for use by the cloud-based access management service to provide authentication services to the applications by users to migrate authentication of the users from the on-premise access management service to the cloud-based access management service.

Abstract: The present invention provides a novel isolated succinate prodrug as the free com-pound or a salt, hydrate, solvate or complex thereof being cell permeable and aimed for increasing the ATP-production in mitochondria. The compound is useful in the medical treatment of a range of diseases, in nutritional supplements, nutricosmetics and in cosmetics.

Abstract: Techniques for geospatial-temporal pathogen tracing include: obtaining, from multiple mobile devices in association with a first time, first contact tracing data including at least first geospatial traffic data and first values of a set of attributes associated with a pathogen; obtaining, from the multiple mobile devices in association with a second time, second contact tracing data including at least second geospatial traffic data and second values of the set of attributes associated with the pathogen; and applying at least the first contact tracing data and the second contact tracing data to a machine learning model, to obtain actionable intelligence associated with the pathogen.

Abstract: Techniques for geospatial-temporal pathogen tracing in zero knowledge include: generating, by a first user device, a first proximity token for contact tracing; receiving, by the first user device, a second proximity token from a second user device; generating, by the first user device, a hash based on the first proximity token and the second proximity token; generating, by the first user device using a prover function of a preprocessing zero knowledge succinct non-interactive argument of knowledge (pp-zk-SNARK), a cryptographic proof attesting that an individual associated with the first user device tested positive for a pathogen; transmitting, by the first user device, first publicly verifiable exposure data including at least the cryptographic proof and the hash to a public registry; and applying at least the first publicly verifiable exposure data and second publicly verifiable exposure data to a machine learning model, to obtain actionable intelligence associated with the pathogen.

Abstract: The present invention relates to sanglifehrin macrocyclic analogues according to Formula (I), particularly for use in treatment of cancer, especially liver cancer.

Abstract: The present invention provides inter alia methods for generating a library of cells producing polyketides and selecting for these strains based on binding to a protein target.

Abstract: The present invention relates to uses of sanglifehrin macrocyclic analogues in treatment of cancer, especially liver cancer.

Abstract: The present invention provides novel liver-targeted prodrugs of mitochondrial proton ionophores. These compounds have utility in medicine including their use in treatment of diseases such as NASH and NAFLD.

Abstract: In various embodiments novel rapamycin analogs are provides that show improved mTORC1 specificity.

Abstract: A method for increasing the molecular diversity of polyketides and non-ribosomal peptides by using recombination to efficiently increase or decrease the number of modules in the polyketide synthase or non-ribosomal peptide synthetase encoding the polyketide or peptide.

Abstract: A method of supporting a chain stopper on a vessel, a chain stopper assembly for a vessel, and a vessel. The method of supporting a chain stopper on a vessel may comprise the steps of connecting a swivel element to the support structure on the vessel such that the swivel element is pivotable around a first axis perpendicular to a substantially horizontal axis; and coupling a chain stopper element to the swivel element such that the chain stopper element is pivotable relative to the swivel element around the substantially horizontal axis.

Abstract: A method for increasing the molecular diversity of polyketides and non-ribsomomal peptides by using recombination to efficiently increase or decrease the number of modules in the polyketide synthase or non-ribosomal peptide synthetase encoding said polyketide or peptide.