Abstract: The present disclosure provides methods of preventing colorectal cancer and/or killing colibactin-producing E. coli. Also provided are prodrug antibiotics suitable for preventing colorectal cancer and/or killing colibactin-producing E. coli, and methods of making prodrug antibiotics. Various prodrug antibiotics may be used. For example, a prodrug antibiotic may be: or any combination thereof, wherein R is a substituted or unsubstituted aliphatic group. In various examples, the prodrug antibiotic may be a salt or in the form of a composition.

Abstract: The present invention is directed to novel anticancer compounds which show excellent activity as anticancer agents. The present invention is also directed to pharmaceutical compositions based upon these compounds and methods of treating cancer, including drug resistant, multiple drug resistant, metastatic and recurrent cancer.

Abstract: The present invention is directed to compounds related to precolibactin pharmaceutical compositions based upon these compounds and methods of synthesis which are employed to provide intermediates and final compounds, which are principally alkylating agents and anticancer compounds. The chemical synthetic approach disclosed facilitates the synthesis of numerous precolibactin analogs which can be used in the treatment of cancer.