Abstract: We describe a method of identifying a molecule suitable for the treatment, prophylaxis or alleviation of a GPR86 associated disease, in particular inflammatory disease or pain, the method comprising determining whether a candidate molecule is an agonist or antagonist of GPR86 polypeptide, in which the GPR86 polypeptide comprises the amino acid sequence shown in SEQ ID NO: 3 or SEQ ID NO: 5 or SEQ ID NO: 7, a fragment thereof or a sequence which is at least 90% identical thereto.

Abstract: We describe a method of identifying a molecule suitable for the treatment, prophylaxis or alleviation of a Gpr100 associated disease, in particular diabetes and obesity, the method comprising determining whether a candidate molecule is an agonist or antagonist of Gpr100 polypeptide, in which the Gpr100 polypeptide comprises the amino acid sequence shown in SEQ ID NO: 3 or SEQ ID NO: 5, or a sequence which is at least 90% identical thereto.

Abstract: Example methods, apparatus and articles of manufacture to determine routing for identical virtual private network (VPN) numbers assigned to multiple companies are disclosed. A disclosed example method includes receiving a query from a switch module to determine routing information for a call initiated by a calling party, the query including dialed digits, a calling party identifier, and a route identifier representative of a route via which the call was initiated, selecting a private VPN number look-up table from a plurality of private VPN number look-up tables based on the calling party identifier, and to perform a lookup within the selected private VPN number look-up table based on a portion of the dialed digits and the route identifier, the lookup to identify the routing information associated with the dialed digits, and transmitting the routing information to the switch module.

Abstract: A method and system for handling identical VPN numbers assigned to multiple companies using a nature of address/number identifier initiated as public. The method includes receiving a query from a switch module to determine routing information for a call initiated by a calling party, the query including dialed digits with a nature of address identifier, and a calling party identifier updating the nature of address identifier associated with dialed digits to a private type code if a VPN coding identifier is determined present, looking up routing information associated with the dialed digits in a look-up table corresponding to the calling party identifier if the nature of address identifier includes the private type code, and transmitting the routing information to the switch module.

Abstract: We disclose GPR26 G-protein coupled receptor (GPCR) polypeptides comprising the amino acid sequence shown in SEQ ID NO. 3 or SEQ ID NO: 5, and homologues, variants and derivatives thereof. Nucleic acids capable of encoding GPR26 polypeptide are also disclosed. The GPR26 receptor is useful in the diagnosis and therapy of mental illness.

Abstract: We describe a method of identifying a molecule suitable for the treatment, prophylaxis or alleviation of a Gpr100 associated disease, in particular diabetes and obesity, the method comprising determining whether a candidate molecule is an agonist or antagonist of Gpr100 polypeptide, in which the Gpr100 polypeptide comprises the amino acid sequence shown in SEQ ID NO: 3 or SEQ ID NO: 5, or a sequence which is at least 90% identical thereto.

Abstract: We describe a method of identifying a molecule suitable for the treatment, prophylaxis or alleviation of a GPR86 associated disease, in particular inflammatory disease or pain, the method comprising determining whether a candidate molecule is an agonist or antagonist of GPR86 polypeptide, in which the GPR86 polypeptide comprises the amino acid sequence shown in SEQ ID NO: 3 or SEQ ID NO: 5 or SEQ ID NO: 7, a fragment thereof or a sequence which is at least 90% identical thereto.

Abstract: The present invention relates to novel functions of a known receptor. In particular, the invention relates to the use of a sphingosylphosphorylcholine receptor and/or ligands thereof in the manipulation of the neuronal and limbic systems and diagnosis and treatment of pain.

Abstract: The present invention relates to novel functions of a known receptor. In particular, the invention relates to the use of a galanin-like receptor and/or ligands thereof in the manipulation of the pituitary hormonal axis and reproductive systems.