Abstract: The invention relates to substituted pyrazolo piperidine carboxylic acids, their salts and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular and cardiac diseases, preferably heart failure with reduced and preserved ejection fraction (HFrEF, HFmrEF and HFpEF), hypertension (HTN), peripheral arterial diseases (PAD, PAOD), cardio-renal and kidney diseases, preferably chronic and diabetic kidney disease (CKD and DKD), cardiopulmonary and lung diseases, preferable pulmonary hypertension (PH), and other diseases, preferably neurodegenerative diseases and different forms of dementias, fibrotic diseases, systemic sclerosis (SSc), sickle cell disease (SCD), wound healing disorders such as diabetic foot ulcer (DFU).

Abstract: The invention relates to substituted pyrazolo piperidine carboxylic acids, their salts and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular and cardiac diseases, preferably heart failure with reduced and preserved ejection fraction (HFrEF, HFmrEF and HFpEF), hypertension (HTN), peripheral arterial diseases (PAD, PAOD), cardio-renal and kidney diseases, preferably chronic and diabetic kidney disease (CKD and DKD), cardiopulmonary and lung diseases, preferable pulmonary hypertension (PH), and other diseases, preferably neurodegenerative diseases and different forms of dementias, fibrotic diseases, systemic sclerosis (SSc), sickle cell disease (SCD), wound healing disorders such as diabetic foot ulcer (DFU).

Abstract: An automated anchor inserter system for drilling a pilot hole and inserting an anchor. The system includes a body having a first end and a second end. An input shaft extends from the first end of the body and a guide tube extends from the second end of the body. The system also includes a first drive shaft recess and a second drive shaft recess within the body. A drill drive shaft is moveable within the input shaft and an inserter drive shaft is moveable within the second drive shaft recess. In a first configuration, the input shaft and the drill drive shaft move distally together through the first drive shaft recess and in a second configuration, the drill drive shaft moves proximally relative to the input shaft. In a third configuration, movement of the drill drive shaft moves the inserter drive shaft.

Abstract: A pressure relief device for controlling the outflow of fluid from a surgical site. The pressure relief device includes a cannula body having a proximal end and a distal end with a thread extending along the entire cannula body from the distal end. The device also has a proximal end cap connected to the proximal end of the cannula body, a spacer connected between the cannula body and the proximal end cap, and a proximal seal enclosed between the proximal end cap and the spacer. One or more distal seals can be enclosed between the spacer and the proximal end of the cannula body. The device additionally includes a channel between the spacer and an inner wall of the proximal end cap. Fluid flows out of the device through the channel.