Abstract: A bed comprises substrate support members, each including a load bearing and a base configured to provide contact with a floor. The load bearing member is configured to move vertically relative to the base, while the base and the load bearing member are configured to fit together to maintain lateral alignment of the base and the load bearing member. A load sensor is positioned between the base and the load bearing member, the load bearing member configured to transmit a load from the substrate to the load sensor. A printed circuit board is in communication with the load sensor. A controller is in communication with the printed circuit board of each substrate support member and is configured to receive and process data output by the printed circuit boards.

Abstract: Provides herein are compositions for the treatment of chronic vulval or perineal pain, and of symptoms or conditions associated therewith, comprising an estrogen, optionally estriol, and a tricyclic antidepressant, optionally amitriptyline, formulated for topical, transdermal or transmucosal administration. Also provided are methods for the production of said compositions and to uses thereof in the treatment of chronic vulval or perineal pain, and of symptoms or conditions associated therewith.

Abstract: Provides herein are compositions for the treatment of chronic vulval or perineal pain, and of symptoms or conditions associated therewith, comprising an estrogen, optionally estriol, and a tricyclic antidepressant, optionally amitriptyline, formulated for topical, transdermal or transmucosal administration. Also provided are methods for the production of said compositions and to uses thereof in the treatment of chronic vulval or perineal pain, and of symptoms or conditions associated therewith.

Abstract: Provides herein are compositions for the treatment of chronic vulval or perineal pain, and of symptoms or conditions associated therewith, comprising an estrogen, optionally estriol, and a tricyclic antidepressant, optionally amitriptyline, formulated for topical, transdermal or transmucosal administration. Also provided are methods for the production of said compositions and to uses thereof in the treatment of chronic vulval or perineal pain, and of symptoms or conditions associated therewith.

Abstract: A buccal delivery system capable of being blended in a normal dry powder process and compressed using a standard tabletting machine, said buccal delivery system comprising a matrix of: (a) an effective amount of one or more active ingredients; (b) an amount of one or more polyethylene glycols or derivatives thereof having a molecular weight between 1000 to 8000 sufficient to provide the required hardness and time for dissolution of the matrix; (c) 0.05-2% by weight of the total matrix of one or more suspending agents; (d) 0.05-2% by weight of the total matrix of one or more flowing agents; and (e) 0.05-2% by weight of the total matrix of one or more sweeteners.

Abstract: The present invention provides a pharmaceutical composition in the form of a water-based gel comprising: at least one pharmaceutically active compound; at least one gelling agent; a solubilising agent; and water, wherein said composition is free or substantially free of unsubstituted monohydric alcohols having between 1 and 6 carbon atoms. The invention also relates to methods for preparing the compositions and uses thereof.

Abstract: A buccal delivery system capable of being blended in a normal dry powder process and compressed using a standard tabletting machine, said buccal delivery system comprising a matrix of: (a) an effective amount of one or more active ingredients; (b) an amount of one or more polyethylene glycols or derivatives thereof having a molecular weight between 1000 to 8000 sufficient to provide the required hardness and time for dissolution of the matrix; (c) 0.05-2% by weight of the total matrix of one or more suspending agents; (d) 0.05-2% by weight of the total matrix of one or more flowing agents; and (e) 0.05-2% by weight of the total matrix of one or more sweeteners.

Abstract: A buccal delivery system capable of being blended in a normal dry powder process and compressed using a standard tabletting machine, said buccal delivery system comprising a matrix of: (a) an effective amount of one or more active ingredients; (b) an amount of one or more polyethylene glycols or derivatives thereof having a molecular weight between 1000 to 8000 sufficient to provide the required hardness and time for dissolution of the matrix; (c) 0.05-2% by weight of the total matrix of one or more suspending agents; (d) 0.05-2% by weight of the total matrix of one or more flowing agents; and (e) 0.05-2% by weight of the total matrix of one or more sweeteners.

Abstract: The present invention relates to topical anaesthetic compositions, uses thereof and methods for their preparation.

Abstract: For use in bodily cavities, a topical anesthetic combination having a pH adjusted to optimize the effectiveness of the anesthetic, a viscosity appropriate to displace tissue debris and enhance retention, and addition of chemicals which increase the bio-availability of the anesthetic molecules.

Abstract: An architecture for communicating with telemetering interface units (TIUs). The system comprises an application controller which interfaces with service vendors who make requests for telemetering metering actions and/or control actions; or network server for communicating via UTTs, (Utility Telemetry Trunks), with an end office switch for accessing TIUs, using a suppressed ringing connection to distinguish between telemetering connections and telephone connections; a service control point (SCP), for providing data about the telecommunications network, the data being necessary in order to allow the network server to access the correct TIU, and a data network for interconnecting the application controller, network server and switching control point. Advantageously, using this arrangement, the functions of the application controller which interfaces with the service vendor are segregated from the functions for controlling the telecommunication network to access the TIU.

Abstract: A method of operating a telecommunications network to provide network-based messaging services includes utilizing a communication link between the network and a telephone adjunct interface. The adjunct interface detects and alerts the subscriber to the existence of waiting messages. In accordance with an illustrative embodiment of the invention, a combination of AC ring detection and outcall polling of the network is employed to determine whether any messages have been received by the network service platform. Specifically, if the subscriber phone is not answered after a predetermined number of rings, the interface polls the network after a suitable delay to determine if any messages were left. If so, the network transmits a code or other signal that is recognized by the interface device, and a visual and/or audible indication is then provided to the subscriber.

Abstract: A telephone adjunct interface for use with a network-based voice and/or data message storage and delivery service detects and alerts the subscriber to the existence of waiting messages. The interface device utilizes a combination of AC ring detection and outcall polling of the network to determine whether a visual and/or audible notification should be provided to the subscriber. That is, if the subscriber phone is not answered after a selected number of rings, the interface polls the network after a suitable delay to determine if any messages were left. If the subscriber line is busy or on call-forward while a calling party is seeking to leave a message, the network service platform stores the message and waits a selected interval before seeking to alert the subscriber. Advantageously, the device is configured as a small, portable and inexpensive consumer premise unit which connects easily to all standard analog telephone systems that use modular connectors.