Patents by Inventor Alan Hruza

Alan Hruza has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ERK2 crystals
    Publication number: 20060088924
    Abstract: The present invention relates to crystals of the ERK2 polypeptide and complexes thereof which are useful, inter alia, for structure assisted drug design.
    Type: Application
    Filed: September 23, 2005
    Publication date: April 27, 2006
    Inventors: Jessie English, Thierry Fischmann, Thomas Hesson, Alan Hruza, Weihong Jin, Paul Reichert, Catherine Smith, Shahriar Taremi
  • Method for producing metal-interferon-.alpha. crystals
    Patent number: 5602232
    Abstract: A method for producing a crystalline zinc interferon (IFN) .alpha.-2 comprising forming a soluble solution of IFN .alpha.-2 and a metal acetate salt under condtions wherein supersaturation and metal alpha interferon crystals occur.
    Type: Grant
    Filed: December 14, 1994
    Date of Patent: February 11, 1997
    Assignee: Schering Corporation
    Inventors: Paul Reichert, Charles McNemar, Nagamani Nagahhushan, Tattanahalli L. Nagahhushan, Stephen Tindall, Alan Hruza
  • Metal-interferon-alpha crystals
    Patent number: 5441734
    Abstract: The present invention provides for crystalline zinc-interferon alfa-2 (IFN .alpha.-2) having a monoclinic morphology. The present invention further provides for crystalline cobalt-IFN .alpha.-2, crystalline calcium-IFN .alpha.-2, and crystalline IFN .alpha.-2 having a serum half-life of at least about 12 hours when injected into a primate. The present invention further provides for a method for producing a crystalline IFN .alpha.-2 comprising forming a soluble metal-IFN .alpha.-2 complex, and equilibrating the soluble metal-IFN .alpha.-2 complex in solution with an acetate salt of the metal under conditions that will cause the metal-IFN .alpha.-2 solution to become supersaturated and form crystalline metal-IFN .alpha.-2. The present invention also includes crystalline metal-alfa interferon having monoclinic, plate and needle morphologies.
    Type: Grant
    Filed: February 25, 1993
    Date of Patent: August 15, 1995
    Assignee: Schering Corporation
    Inventors: Paul Reichert, Charles McNemar, Nagamani Nagabhushan, Tattanahalli L. Nagabhushan, Stephen Tindall, Alan Hruza