Abstract: The invention provides a versatile technique for machining of nanometer-scale features using tightly-focused ultrashort laser pulses. By the invention, the size of features can be reduced far below the wavelength of light, thus enabling nanomachining of a wide range of materials. The features may be extremely small, of nanometer size, and are highly reproducible.

Abstract: An apparatus for inspecting a sealed container is disclosed and which includes a pulsed electron accelerator which is positioned in spaced relation relative to a first side of the sealed container, and which produces a pulsed beam of photons which passes through the sealed container and any contents enclosed within the sealed container; a detector positioned in spaced relation relative to a second, opposite side of the sealed container, and which receives the pulsed beam of photons which passes through the contents of the sealed container, and which produces an output signal; and means for developing a visible image from the output signal of the detector which depicts the contents of the sealed container.

Abstract: Substituted carbocyclic sulphonamide derivatives of formula (I), in which n is 0 or 1 and the other variables are as defined in the claims, are selective 5-HT7 receptor antagonists and are thereby effective in the treatment of a variety of neurological conditions, including depression and sleep disorders.

Abstract: The compounds of formula I: inhibit gamma secretase and hence are of utility in the treatment or prevention of Alzheimer's Disease.

Abstract: Methods and compositions for detecting the assembly of complexes include providing a solution where a first portion is separated from a second portion via a submicrometer pore, submicrometer tube or channel, nanopore, or nanotube or channel. One or more submicrometer or nanometer sized object(s) is added to the first portion of the solution. Due to molecular interactions, these objects assemble to form complexes consisting of two or more submicrometer or nanometer sized objects. Passage of a complex from the first portion of the solution through the submicrometer pore, submicrometer tube or channel, nanopore, or nanotube or channel to the second portion of the solution is detected using resistive pulse sensing. This sensing methodology may comprise detecting formation of complexes in real-time and/or may comprise detecting preassembled complexes.

Abstract: Compounds of formula I: are potent and selective antagonists of the human 5-HT2A receptor, and hence useful in treatment of a variety of adverse conditions of the CNS.

Abstract: Here is presented a versatile technique for machining of nanometer-scale features using tightly-focused ultrashort laser pulses. By the invention, the size of features can be reduced far below the wavelength of light, thus enabling nanomachining of a wide range of materials. The features may be extremely small (<20 nm) and are highly reproducible.

Abstract: The present invention relates to sulfone derivatives of formula (I): Ar—SO2—CR2R3-L-N(R1)2I wherein Ar, L, R1, R2 and R3 are as defined herein, and pharmaceutically acceptable salts and N-oxides thereof, useful in the treatment of a condition which is susceptible to treatment by modulation of 5-HT7 receptor activity, such as depression or a sleep disorder.

Abstract: A support for immobilizing target molecules comprises a substrate having a plurality of binding regions for binding select target molecules, with target-molecule-capturing agent immobilized at the binding regions. The binding regions are intersperse among other non-binding regions. The binding regions are of sub-micron size, have high selectivity and high binding capacity, and prevent or at least minimize loss of target molecule activity.

Abstract: The invention provides a versatile technique for machining of nanometer-scale features using tightly-focused ultrashort laser pulses. By the invention, the size of features can be reduced far below the wavelength of light, thus enabling nanomachining of a wide range of materials. The features may be extremely small, of nanometer size, and are highly reproducible.

Abstract: The present invention relates to sulfone derivatives of formula (I):

Abstract: Gamma-secretase inhibitors, useful in the treatment or prevention of Alzheimer's disease, are disclosed. The preferred compounds have, as the central portion of the molecule, the structure (a) and are di-astereoisomers of known protease inhibitors.

Abstract: A modular cooling system adapter for coupling to an orifice and applying pressure from a source of pressurized gas. The adapter includes a universal cooling orifice fitting for attaching the device to cooling system orifices of various sizes and configurations. The universal fitting preferably includes a plurality of steps having outer axially extending surfaces disposed at a slight negative angle to a plane parallel to the axial direction. The adapter may include a pressure adapter for coupling to a source of pressurized gas, such that the pressure adapter can be interchanged with other diagnostic tools including a valve assembly, a valve assembly incorporating a temperature probe and gauge and/or a pressure gauge. Additionally, the cooling system adapter is fully modular in that it allows quick disassembly for replacement of components and interchangeability of diagnostic tools.

Abstract: There is disclosed a method of characterising a chemical reaction, in terms of the structural changes occurring thereby, by means of a reaction vector value. The method may be used to identify and quantify objective similarities among members of a selected group of reactions, or between a probe reaction and members of a selected group of reactions.

Abstract: Gamma-secretase inhibitors, useful in the treatment or prevention of Alzheimer's disease, are disclosed. The preferred compounds have, as the central portion of the molecule, the structure (a) and are diastereoisomers of known protease inhibitors.

Abstract: A modular cooling system adapter for coupling to an orifice and applying pressure from a source of pressurized gas. The adapter includes a universal cooling orifice fitting for attaching the device to cooling system orifices of various sizes and configurations. The universal fitting preferably includes a plurality of steps having outer axially extending surfaces disposed at a slight negative angle to a plane parallel to the axial direction. The adapter may include a pressure adapter for coupling to a source of pressurized gas, such that the pressure adapter can be interchanged with other diagnostic tools including a valve assembly, a valve assembly incorporating a temperature probe and gauge and/or a pressure gauge. Additionally, the cooling system adapter is fully modular in that it allows quick disassembly for replacement of components and interchangeability of diagnostic tools.