Abstract: An article of manufacture which provides structural support for overhead door track systems while concealing the tracks from view, consisting of vertical and horizontal members, which attach to and support the tracks, and which are manufactured with recessed channels or trim elements for visual concealment of the tracks.

Abstract: The present invention provides methods for isolating an active polypeptide or immunoconjugate by purification of a solution containing both the active polypeptide or immunoconjugate and an acidic variant thereof, such as a deamidated variant, using anion exchange chromatography. The present invention also provides compositions, formulations, and unit dosage forms comprising the purified polypeptide or immunoconjugate.

Abstract: A multilayer beauty care product or method is provided. The beauty care product has a water soluble film zone that includes a water soluble film forming polymer and a cosmetic composition with an effective amount of a skin active agent. The product also has a barrier patch having a backing layer and a pressure sensitive adhesive zone. The adhesive zone and the water soluble film zone are continuous, discontinuous, or a combination thereof. The product exhibits a dynamic modulus.

Abstract: The present invention provides methods for isolating an active polypeptide or immunoconjugate by purification of a solution containing both the active polypeptide or immunoconjugate and an acidic variant thereof, such as a deamidated variant, using anion exchange chromatography. The present invention also provides compositions, formulations, and unit dosage forms comprising the purified polypeptide or immunoconjugate.

Abstract: A beauty care product is provided. The beauty care product is a multi-layered barrier patch with a water soluble film zone comprising a polyethylene oxide, methylcellulose, hydroxypropyl methylcellulose, hydroxypropylcellulose, and combinations thereof, and a cosmetic composition comprising an effective amount of a skin active agent. The product also has a barrier patch with a backing layer and a pressure sensitive adhesive zone wherein the adhesive zone and the soluble film zone are continuous, discontinuous, or a combination thereof. The soluble film zone or product is capable of changing from a first visual state to a second visual state.

Abstract: A multilayer beauty care product or method is provided. The beauty care product has a water soluble film zone that includes a water soluble film forming polymer and a cosmetic composition with an effective amount of a skin active agent. The product also has a barrier patch having a backing layer and a pressure sensitive adhesive zone. The adhesive zone and the water soluble film zone are continuous, discontinuous, or a combination thereof. The product exhibits a dynamic modulus.

Abstract: A beauty care product is provided. The beauty care product is a multi-layered barrier patch with a water soluble film zone comprising a polyethylene oxide, methylcellulose, hydroxypropyl methylcellulose, hydroxypropylcellulose, and combinations thereof, and a cosmetic composition comprising an effective amount of a skin active agent. The product also has a barrier patch with a backing layer and a pressure sensitive adhesive zone wherein the adhesive zone and the soluble film zone are continuous, discontinuous, or a combination thereof. The soluble film zone or product is capable of changing from a first visual state to a second visual state.

Abstract: The present invention relates to a method of purifying albumin-fusion proteins to reduce the level of oxidation of susceptible amino acid residues. The method comprises an affinity matrix chromatography step and an anion exchange chromatography step. The purified albumin-fusion proteins have low levels of oxidation and retain their enhanced half-life in vivo and its bioactivity. In some embodiments, the albumin-fusion protein comprises a scaffold, such as human Tenascin C scaffold. Compositions comprising the albumin-fusion protein are further disclosed.

Abstract: The present invention provides methods of preparing active immunoconjugates, including anti-CD22 immunoconjugates. Suitably, the methods include a fed-batch refolding process and/or column stripping process that result in an increase in yield of the immunoconjugate over other processes that do not utilize the methods.

Abstract: The present invention provides methods for isolating an active polypeptide or immunoconjugate by purification of a solution containing both the active polypeptide or immunoconjugate and an acidic variant thereof, such as a deamidated variant, using anion exchange chromatography. The present invention also provides compositions, formulations, and unit dosage forms comprising the purified polypeptide or immunoconjugate.

Abstract: A bearing includes a first member having a passageway configured to engage a shaft, the first member having a metallic material; and a second member disposed around at least a portion of the first member, the second member having a metallic material and at least one radially and inwardly bent portion capable of restricting axial movement of the first member. The first and second members are movable relative to each other.

Abstract: The present application relates to methods for purifying recombinant coagulation factor proteins, including for example, prothrombin (Factor II). In embodiments, the methods provide purified prothrombin that exhibit increased bioactivity and reduced levels of thrombin, thereby increasing the safety of the prothrombin. Also provided are purified recombinant coagulation factor proteins.

Abstract: The present invention provides methods for isolating an active polypeptide or immunoconjugate by purification of a solution containing both the active polypeptide or immunoconjugate and an acidic variant thereof, such as a deamidated variant, using anion exchange chromatography.

Abstract: The invention provides a method for removing multimers from a preparation of recombinant polyclonal antibodies (rpAbs) while maintaining the ratio of monomers within a narrow range. The invention provides a method of separating recombinant polyclonal antibody multimers with minimal separation of monomers comprising subjecting a mixture comprising a plurality of monoclonal antibodies to at least one separation process selected from the group consisting of multi-modal chromatography, apatite chromatography, and hydrophobic interaction chromatography thereby producing an antibody monomer preparation that is substantially free of multimers.

Abstract: The present invention provides methods of preparing active immunoconjugates, including anti-CD22 immunoconjugates. Suitably, the methods include a fed-batch refolding process and/or column stripping process that result in an increase in yield of the immunoconjugate over other processes that do not utilize the methods.

Abstract: The present application relates to methods for purifying recombinant coagulation factor proteins, including for example, prothrombin (Factor II). In embodiments, the methods provide purified prothrombin that exhibit increased bioactivity and reduced levels of thrombin, thereby increasing the safety of the prothrombin. Also provided are purified recombinant coagulation factor proteins.

Abstract: A roof valley water diverter is provided herein for changing direction of rain water flowing through a roof valley. The diverter includes at least first and second side plates joined together to form a trough extending along a longitudinal axis and configured to channel a flow of rain water therethrough. A deflector plate, having opposing first and second faces, is secured to at least the first and second side plates such that the first face intersects the longitudinal axis. At least one gap is defined between the first face and at least one of the first and second side plates. Advantageously, the diverter of the subject invention allows for re-direction of flow of rain water from a roof valley.

Abstract: A bearing includes a first member having a passageway configured to engage a shaft, the first member having a metallic material; and a second member disposed around at least a portion of the first member, the second member having a metallic material and at least one radially and inwardly bent portion capable of restricting axial movement of the first member. The first and second members are movable relative to each other.

Abstract: The present invention provides methods for isolating an active polypeptide or immunoconjugate by purification of a solution containing both the active polypeptide or immunoconjugate and an acidic variant thereof, such as a deamidated variant, using anion exchange chromatography.

Abstract: A bearing includes a first member having a passageway configured to engage a shaft, the first member having a metallic material; and a second member disposed around at least a portion of the first member, the second member having a metallic material and at least one radially and inwardly bent portion capable of restricting axial movement of the first member. The first and second members are movable relative to each other.