Patents by Inventor Alan J. Levy

Alan J. Levy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190275308
    Abstract: A two-part bioactive agent delivery system, the system including a disposable part comprising an agent reservoir, a bolus chamber, the volume of the bolus chamber being less than the volume of the agent reservoir, an agent outlet, and a valve having a first position communicating the agent reservoir with the bolus chamber and a second position communicating the bolus chamber with the outlet; and a reusable part including a valve driver, a power source and control electronics, the control electronics being adapted to control the valve driver to actuate the valve to deliver bioactive agent from the agent reservoir to the agent outlet; the system further having a spring extending between the agent reservoir piston and a surface of the reusable part or of the disposable part to pressurize the agent reservoir when the spring is compressed and the agent reservoir contains a quantity of bioactive agent.
    Type: Application
    Filed: February 25, 2019
    Publication date: September 12, 2019
    Applicant: Chrono Therapeutics Inc.
    Inventors: Zita S. NETZEL, Gary STACEY, Alexander David NORMAN, Congyi HUANG, Timothy Charles FREARSON, Charles Frazer KILBY, Patrick H. RUANE, Alan J. LEVY, Kevin W. GELSTON, Jennifer DARMOUR, Jenny E. HAPGOOD, David Evans ROTH, Ronald A. OVERBECK, Ling-Kang TONG
  • Patent number: 10232156
    Abstract: A two-part bioactive agent delivery system, the system including a disposable part comprising an agent reservoir, a bolus chamber, the volume of the bolus chamber being less than the volume of the agent reservoir, an agent outlet, and a valve having a first position communicating the agent reservoir with the bolus chamber and a second position communicating the bolus chamber with the outlet; and a reusable part including a valve driver, a power source and control electronics, the control electronics being adapted to control the valve driver to actuate the valve to deliver bioactive agent from the agent reservoir to the agent outlet; the system further having a spring extending between the agent reservoir piston and a surface of the reusable part or of the disposable part to pressurize the agent reservoir when the spring is compressed and the agent reservoir contains a quantity of bioactive agent.
    Type: Grant
    Filed: September 8, 2017
    Date of Patent: March 19, 2019
    Assignee: Chrono Therapeutics Inc.
    Inventors: Zita S. Netzel, Gary Stacey, Alexander David Norman, Congyi Huang, Timothy Charles Frearson, Charles Frazer Kilby, Patrick H. Ruane, Alan J. Levy, Kevin W. Gelston, Jennifer Darmour, Jenny E. Hapgood, David Evans Roth, Ronald A. Overbeck, Ling-Kang Tong
  • Patent number: 10213586
    Abstract: A two-part bioactive agent delivery system, the system including a disposable part comprising an agent reservoir, a bolus chamber, the volume of the bolus chamber being less than the volume of the agent reservoir, an agent outlet, and a valve having a first position communicating the agent reservoir with the bolus chamber and a second position communicating the bolus chamber with the outlet; and a reusable part including a valve driver, a power source and control electronics, the control electronics being adapted to control the valve driver to actuate the valve to deliver bioactive agent from the agent reservoir to the agent outlet; the system further having a spring extending between the agent reservoir piston and a surface of the reusable part or of the disposable part to pressurize the agent reservoir when the spring is compressed and the agent reservoir contains a quantity of bioactive agent.
    Type: Grant
    Filed: January 28, 2016
    Date of Patent: February 26, 2019
    Assignee: Chrono Therapeutics Inc.
    Inventors: Zita S. Netzel, Gary Stacey, Alexander David Norman, Congyi Huang, Timothy Charles Frearson, Charles Frazer Kilby, Patrick H. Ruane, Alan J. Levy, Kevin W. Gelston, Jennifer Darmour, Jenny E. Hapgood, David Evans Roth, Ronald A. Overbeck, Ling-Kang Tong
  • Publication number: 20180117291
    Abstract: A two-part bioactive agent delivery system, the system including a disposable part comprising an agent reservoir, a bolus chamber, the volume of the bolus chamber being less than the volume of the agent reservoir, an agent outlet, and a valve having a first position communicating the agent reservoir with the bolus chamber and a second position communicating the bolus chamber with the outlet; and a reusable part including a valve driver, a power source and control electronics, the control electronics being adapted to control the valve driver to actuate the valve to deliver bioactive agent from the agent reservoir to the agent outlet; the system further having a spring extending between the agent reservoir piston and a surface of the reusable part or of the disposable part to pressurize the agent reservoir when the spring is compressed and the agent reservoir contains a quantity of bioactive agent.
    Type: Application
    Filed: September 8, 2017
    Publication date: May 3, 2018
    Inventors: Zita S. NETZEL, Gary STACEY, Alexander David NORMAN, Congyi HUANG, Timothy Charles FREARSON, Charles Frazer KILBY, Patrick H. RUANE, Alan J. LEVY, Kevin W. GELSTON, Jennifer DARMOUR, Jenny E. HAPGOOD, David Evans ROTH, Ronald A. OVERBECK, Ling-Kang TONG
  • Publication number: 20160220798
    Abstract: A two-part bioactive agent delivery system, the system including a disposable part comprising an agent reservoir, a bolus chamber, the volume of the bolus chamber being less than the volume of the agent reservoir, an agent outlet, and a valve having a first position communicating the agent reservoir with the bolus chamber and a second position communicating the bolus chamber with the outlet; and a reusable part including a valve driver, a power source and control electronics, the control electronics being adapted to control the valve driver to actuate the valve to deliver bioactive agent from the agent reservoir to the agent outlet; the system further having a spring extending between the agent reservoir piston and a surface of the reusable part or of the disposable part to pressurize the agent reservoir when the spring is compressed and the agent reservoir contains a quantity of bioactive agent.
    Type: Application
    Filed: January 28, 2016
    Publication date: August 4, 2016
    Inventors: Zita S. NETZEL, Gary STACEY, Alexander David NORMAN, Congyi HUANG, Timothy Charles FREARSON, Charles Frazer KILBY, Patrick H. RUANE, Alan J. LEVY, Kevin W. GELSTON, Jennifer DARMOUR, Jenny E. HAPGOOD, David Evans ROTH, Ronald A. OVERBECK, Ling-Kang TONG
  • Publication number: 20120316630
    Abstract: The following disclosure describes several methods and apparatus for intracranial electrical stimulation to treat or otherwise effectuate a change in neural-functions of a patient. The methods in accordance with the invention can be used to treat brain damage (e.g., stroke, trauma, etc.), brain disease (e.g., Alzheimer's, Pick's, Parkinson's, etc.), and/or brain disorders (e.g., epilepsy, depression, etc.). The methods in accordance with the invention can also be used to enhance neural-function of normal, healthy brains (e.g., learning, memory, etc.), or to control sensory functions (e.g., pain).
    Type: Application
    Filed: August 16, 2012
    Publication date: December 13, 2012
    Inventors: Andrew D. Firlik, Jeffrey Balzer, Bradford Evan Gliner, Alan J. Levy, Carlton B. Morgan, Katrina S. Firlik
  • Publication number: 20120253442
    Abstract: A device and method for intracranial electrical stimulation to effectuate a change in neural-functions of a patient, by electrical stimulating the brain at a site where neuroplasticity is occurring or is expected to occur, where the stimulation site may be different than the region in the brain where neural activity is typically present to perform the particular neural function according to the functional organization of the brain. In one embodiment in which neuroplasticity is related to the neural-function occurs in the brain, identifying the location where such neuroplasticity is present or expected to occur. Where neuroplasticity is not occurring in the brain, an alternative aspect is to induce neuroplasticity at a stimulation site where it is expected to occur. The methods can use electrical pulses that increase the resting membrane potential of neurons at the stimulation site to a subthreshold level.
    Type: Application
    Filed: April 3, 2012
    Publication date: October 4, 2012
    Inventors: Bradford Evan Gliner, Brad Fowler, Andrew D. Firlik, Jeffrey Balzer, Alan J. Levy, Kent Leyde
  • Publication number: 20120022611
    Abstract: The following disclosure describes several methods and apparatus for intracranial electrical stimulation to treat or otherwise effectuate a change in neural-functions of a patient. The methods in accordance with the invention can be used to treat brain damage (e.g., stroke, trauma, etc.), brain disease (e.g., Alzheimer's, Pick's, Parkinson's, etc.), and/or brain disorders (e.g., epilepsy, depression, etc.). The methods in accordance with the invention can also be used to enhance neural-function of normal, healthy brains (e.g., learning, memory, etc.), or to control sensory functions (e.g., pain).
    Type: Application
    Filed: September 22, 2011
    Publication date: January 26, 2012
    Applicant: ADVANCED NEUROMODULATION SYSTEMS, INC.
    Inventors: Andrew D. Firlik, Jeffrey Balzer, Bradford Evan Gliner, Alan J. Levy, Carlton B. Morgan, Katrina S. Firlik
  • Patent number: 8065012
    Abstract: Disclosed are several apparatuses and methods for applying intracranial electrical stimulation to treat or enhance the neural function of the patient. In accordance with the invention, intracranial electrical stimulation can be administered to treat brain damage, brain disease, and/or brain disorders. Additionally the intracranial electrical stimulation can be applied to a normal healthy brain to enhance neural-function or control sensory functions. The electrical stimulation site(s) of the brain are located where neuroplasticity is occurring, expected to occur, or in a region where neuroplasticity is not occurring. The intracranial stimulation is expected to produce a lasting effect on the intended neural activity by applying subthreshold stimulation to the increasing the resting membrane potential of the neurons at the stimulation site.
    Type: Grant
    Filed: August 6, 2007
    Date of Patent: November 22, 2011
    Assignee: Advanced Neuromodulation Systems, Inc.
    Inventors: Andrew D. Firlik, Jeffrey Balzer, Bradford Evan Gliner, Alan J. Levy, Carlton B. Morgan, Katrina S. Firlik
  • Patent number: 8050768
    Abstract: The present disclosure is directed generally to methods and apparatus for effectuating a change in a neural function of a patient. A method in accordance with a particular embodiment includes implanting an electrode at a cortical stimulation site selected to promote recovery of the affected neural-function, with the cortical stimulation site being at least proximate to the cortex. The method can further include estimating a threshold for the specific patient at which an electrical signal delivered via the implanted electrode directly triggers a neural reaction associated with the stimulation site in response to the delivered electrical signal, and electrically stimulating the cortical stimulation site by passing an electrical current through the electrode.
    Type: Grant
    Filed: December 23, 2008
    Date of Patent: November 1, 2011
    Assignee: Advanced Neuromodulation Systems, Inc.
    Inventors: Andrew D. Firlik, Bradford Evan Gliner, Alan J. Levy, Katrina S. Firlik
  • Patent number: 8019425
    Abstract: Methods and apparatus for treating an impaired neural function in a brain of a patient. In one embodiment, a method for treating a neural function in a brain of a patient includes determining a therapy period during which a plurality of therapy sessions are to be performed to recover functional ability corresponding to the neural function. The method continues by identifying a stimulation site in or on the brain of the patient associated with the neural function, and positioning an electrode at least proximate to the identified stimulation site. The patient is then treated by providing electrical stimulation treatments to the stimulation site. The treatment can comprise delivering electrical stimulation signals to the electrode during the therapy sessions. After expiration of the therapy period, the method includes preventing electrical stimulation signals from being delivered to the stimulation site.
    Type: Grant
    Filed: December 23, 2008
    Date of Patent: September 13, 2011
    Assignee: Advanced Neuromodulation Systems, Inc.
    Inventors: Andrew D. Firlik, Jeffrey Balzer, Alan J. Levy, Bradford Evan Gliner, Katrina S. Firlik
  • Publication number: 20100274305
    Abstract: The following disclosure describes several methods and apparatus for stimulating cells implanted in the regions of nervous system, such as the brain, spinal cord or peripheral nerves. Accordingly, the functionality of the cells can be improved, for example, by differentiating undifferentiated or partially undifferentiated cells into neurons or other cells having action potentials. The method can also include promoting directional growth and connectivity of fully differentiated neural cells implanted in a patient's nervous system through electrical enhancement, for example, electrical stimulation via an anode and cathode. Methods in accordance with the invention can be used to treat brain damage (e.g., stroke, trauma, etc.), brain disease (e.g., Alzheimer's, Pick's, Parkinson's, etc.), and/or brain disorders (e.g., epilepsy, depression, etc.). The methods in accordance with the invention can also be used to enhance neural-function of normal, healthy brains (e.g., learning, memory, etc.
    Type: Application
    Filed: April 30, 2010
    Publication date: October 28, 2010
    Inventors: Bradford Evan Gliner, Alan J. Levy, Jeffrey Balzer, Andrew D. Firlik, W. Doughlas Sheffield
  • Publication number: 20100145427
    Abstract: The following disclosure describes several methods and apparatus for intracranial electrical stimulation to treat or otherwise effectuate a change in neural-functions of a patient. Certain embodiments of methods in accordance with the invention electrically stimulate the brain at a stimulation site where neuroplasticity is occurring or is expected to occur. The stimulation site may be different than the region in the brain where neural activity is typically present to perform the particular neural function according to the functional organization of the brain. In one embodiment in which neuroplasticity related to the neural-function occurs in the brain, the method can include identifying the location where such neuroplasticity is present or expected to occur. In an alternative embodiment in which neuroplasticity is not occurring in the brain, an alternative aspect is to induce neuroplasticity at a stimulation site where it is expected to occur.
    Type: Application
    Filed: February 23, 2010
    Publication date: June 10, 2010
    Applicant: ADVANCED NEUROMODULATION SYSTEMS, INC.
    Inventors: Bradford Evan Gliner, Brad Fowler, Andrew D. Firlik, Jeffrey Balzer, Alan J. Levy, Kent Leyde
  • Publication number: 20100131030
    Abstract: The present disclosure is directed generally to methods and apparatus for effectuating a change in a neural function of a patient. A method in accordance with a particular embodiment includes implanting an electrode at a cortical stimulation site selected to promote recovery of the affected neural-function, with the cortical stimulation site being at least proximate to the cortex. The method can further include estimating a threshold for the specific patient at which an electrical signal delivered via the implanted electrode directly triggers a neural reaction associated with the stimulation site in response to the delivered electrical signal, and electrically stimulating the cortical stimulation site by Passing an electrical current through the electrode.
    Type: Application
    Filed: February 2, 2010
    Publication date: May 27, 2010
    Applicant: ADVANCED NEUROMODULATION SYSTEMS, INC.
    Inventors: Andrew D. Firlik, Bradford Evan Gliner, Alan J. Levy, Katrina S. Firlik
  • Patent number: 7672730
    Abstract: Methods and apparatus for treating an impaired neural function in a brain of a patient. In one embodiment, a method for treating a neural function in a brain of a patient includes determining a therapy period during which a plurality of therapy sessions are to be performed to recover functional ability corresponding to the neural function. The method continues by identifying a stimulation site in or on the brain of the patient associated with the neural function, and positioning an electrode at least proximate to the identified stimulation site. The patient is then treated by providing electrical stimulation treatments to the stimulation site. The treatment can comprise delivering electrical stimulation signals to the electrode during the therapy sessions. After expiration of the therapy period, the method includes preventing electrical stimulation signals from being delivered to the stimulation site.
    Type: Grant
    Filed: June 24, 2003
    Date of Patent: March 2, 2010
    Assignee: Advanced Neuromodulation Systems, Inc.
    Inventors: Andrew D. Firlik, Jeffrey Balzer, Bradford Evan Gliner, Alan J. Levy
  • Publication number: 20090319000
    Abstract: The present disclosure is directed generally to methods and apparatus for effectuating a change in a neural function of a patient. A method in accordance with a particular embodiment includes implanting an electrode at a cortical stimulation site selected to promote recovery of the affected neural-function, with the cortical stimulation site being at least proximate to the cortex. The method can further include estimating a threshold for the specific patient at which an electrical signal delivered via the implanted electrode directly triggers a neural reaction associated with the stimulation site in response to the delivered electrical signal, and electrically stimulating the cortical stimulation site by Passing an electrical current through the electrode.
    Type: Application
    Filed: December 23, 2008
    Publication date: December 24, 2009
    Inventors: Andrew D. Firlik, Bradford Evan Gliner, Alan J. Levy, Katrina S. Firlik
  • Patent number: 7577481
    Abstract: The following disclosure describes a method for intracranial electrical stimulation to treat or otherwise effectuate a change in neural-functions of a patient. Several embodiments are directed toward enhancing or otherwise inducing a lasting change in neural activity to effectuate a particular neural-function. Such lasting change in neural activity is defined as “neuroplasticity.” The methods can be used to treat brain damage (e.g., stroke, trauma, etc.), brain disease (e.g., Alzheimer's, Pick's, Parkinson's, etc.), and/or brain disorders (e.g., epilepsy, depression, etc.). The methods can also be used to enhance neural-function of normal, healthy brains (e.g., learning, memory, etc.), or to control sensory functions (e.g., pain).
    Type: Grant
    Filed: February 15, 2006
    Date of Patent: August 18, 2009
    Assignee: Advanced Neuromodulation Systems, Inc.
    Inventors: Andrew D. Firlik, Jeffrey Balzer, Bradford Evan Gliner, Alan J. Levy, Carlton B. Morgan, Katrina S. Firlik
  • Publication number: 20090171416
    Abstract: Methods and apparatus for treating an impaired neural function in a brain of a patient. In one embodiment, a method for treating a neural function in a brain of a patient includes determining a therapy period during which a plurality of therapy sessions are to be performed to recover functional ability corresponding to the neural function. The method continues by identifying a stimulation site in or on the brain of the patient associated with the neural function, and positioning an electrode at least proximate to the identified stimulation site. The patient is then treated by providing electrical stimulation treatments to the stimulation site. The treatment can comprise delivering electrical stimulation signals to the electrode during the therapy sessions. After expiration of the therapy period, the method includes preventing electrical stimulation signals from being delivered to the stimulation site.
    Type: Application
    Filed: December 23, 2008
    Publication date: July 2, 2009
    Inventors: Andrew D. Firlik, Jeffrey Balzer, Alan J. Levy, Bradford Evan Gliner, Katrina S. Firlik
  • Publication number: 20080215112
    Abstract: The following disclosure describes several methods and apparatus for intracranial electrical stimulation to treat or otherwise effectuate a change in neural-functions of a patient. Several embodiments of methods in accordance with the invention are directed toward enhancing or otherwise inducing a lasting change in neural activity to effectuate a particular neural-function. Such lasting change in neural activity is defined as “neuroplasticity.” The methods in accordance with the invention can be used to treat brain damage (e.g., stroke, trauma, etc.), brain disease (e.g., Alzheimer's, Pick's, Parkinson's, etc.), and/or brain disorders (e.g., epilepsy, depression, etc.). The methods in accordance with the invention can also be used to enhance neural-function of normal, healthy brains (e.g., learning, memory, etc.), or to control sensory functions (e.g., pain).
    Type: Application
    Filed: August 6, 2007
    Publication date: September 4, 2008
    Applicant: Northstar Neuroscience, Inc.
    Inventors: Andrew D. Firlik, Jeffrey Balzer, Bradford Evan Gliner, Alan J. Levy, Carlton B. Morgan, Katrina S. Firlik
  • Publication number: 20080161879
    Abstract: The following disclosure describes several methods and apparatus for intracranial electrical stimulation to treat or otherwise effectuate a change in neural-functions of a patient. Several embodiments of methods in accordance with the invention are directed toward enhancing or otherwise inducing a lasting change in neural activity to effectuate a particular neural-function. Such lasting change in neural activity is defined as “neuroplasticity.” The methods in accordance with the invention can be used to treat brain damage (e.g., stroke, trauma, etc.), brain disease (e.g., Alzheimer's, Pick's, Parkinson's, etc.), and/or brain disorders (e.g., epilepsy, depression, etc.). The methods in accordance with the invention can also be used to enhance neural-function of normal, healthy brains (e.g., learning, memory, etc.), or to control sensory functions (e.g., pain).
    Type: Application
    Filed: August 6, 2007
    Publication date: July 3, 2008
    Applicant: Northstar Neuroscience, Inc.
    Inventors: Andrew D. Firlik, Jeffrey Balzer, Bradford Evan Gliner, Alan J. Levy, Carlton B. Morgan, Katrina S. Firlik