Patents by Inventor Alan J. Levy
Alan J. Levy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230191097Abstract: A two-part bioactive agent delivery system, the system including a disposable part comprising an agent reservoir, a bolus chamber, the volume of the bolus chamber being less than the volume of the agent reservoir, an agent outlet, and a valve having a first position communicating the agent reservoir with the bolus chamber and a second position communicating the bolus chamber with the outlet; and a reusable part including a valve driver, a power source and control electronics, the control electronics being adapted to control the valve driver to actuate the valve to deliver bioactive agent from the agent reservoir to the agent outlet; the system further having a spring extending between the agent reservoir piston and a surface of the reusable part or of the disposable part to pressurize the agent reservoir when the spring is compressed and the agent reservoir contains a quantity of bioactive agent.Type: ApplicationFiled: July 28, 2022Publication date: June 22, 2023Inventors: Zita S. NETZEL, Gary STACEY, Alexander David NORMAN, Congyi HUANG, Timothy Charles FREARSON, Charles Frazer KILBY, Patrick H. RUANE, Alan J. LEVY, Kevin W. GELSTON, Jennifer DARMOUR, Jenny E. HAPGOOD, David Evans ROTH, Ronald A. OVERBECK, Ling-Kang TONG
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Patent number: 11400266Abstract: A two-part bioactive agent delivery system, the system including a disposable part comprising an agent reservoir, a bolus chamber, the volume of the bolus chamber being less than the volume of the agent reservoir, an agent outlet, and a valve having a first position communicating the agent reservoir with the bolus chamber and a second position communicating the bolus chamber with the outlet; and a reusable part including a valve driver, a power source and control electronics, the control electronics being adapted to control the valve driver to actuate the valve to deliver bioactive agent from the agent reservoir to the agent outlet; the system further having a spring extending between the agent reservoir piston and a surface of the reusable part or of the disposable part to pressurize the agent reservoir when the spring is compressed and the agent reservoir contains a quantity of bioactive agent.Type: GrantFiled: February 25, 2019Date of Patent: August 2, 2022Assignee: Morningside Venture Investments LimitedInventors: Zita S. Netzel, Gary Stacey, Alexander David Norman, Congyi Huang, Timothy Charles Frearson, Charles Frazer Kilby, Patrick H. Ruane, Alan J. Levy, Kevin W. Gelston, Jennifer Darmour, Jenny E. Hapgood, David Evans Roth, Ronald A. Overbeck, Ling-Kang Tong
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Publication number: 20190275308Abstract: A two-part bioactive agent delivery system, the system including a disposable part comprising an agent reservoir, a bolus chamber, the volume of the bolus chamber being less than the volume of the agent reservoir, an agent outlet, and a valve having a first position communicating the agent reservoir with the bolus chamber and a second position communicating the bolus chamber with the outlet; and a reusable part including a valve driver, a power source and control electronics, the control electronics being adapted to control the valve driver to actuate the valve to deliver bioactive agent from the agent reservoir to the agent outlet; the system further having a spring extending between the agent reservoir piston and a surface of the reusable part or of the disposable part to pressurize the agent reservoir when the spring is compressed and the agent reservoir contains a quantity of bioactive agent.Type: ApplicationFiled: February 25, 2019Publication date: September 12, 2019Applicant: Chrono Therapeutics Inc.Inventors: Zita S. NETZEL, Gary STACEY, Alexander David NORMAN, Congyi HUANG, Timothy Charles FREARSON, Charles Frazer KILBY, Patrick H. RUANE, Alan J. LEVY, Kevin W. GELSTON, Jennifer DARMOUR, Jenny E. HAPGOOD, David Evans ROTH, Ronald A. OVERBECK, Ling-Kang TONG
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Patent number: 10232156Abstract: A two-part bioactive agent delivery system, the system including a disposable part comprising an agent reservoir, a bolus chamber, the volume of the bolus chamber being less than the volume of the agent reservoir, an agent outlet, and a valve having a first position communicating the agent reservoir with the bolus chamber and a second position communicating the bolus chamber with the outlet; and a reusable part including a valve driver, a power source and control electronics, the control electronics being adapted to control the valve driver to actuate the valve to deliver bioactive agent from the agent reservoir to the agent outlet; the system further having a spring extending between the agent reservoir piston and a surface of the reusable part or of the disposable part to pressurize the agent reservoir when the spring is compressed and the agent reservoir contains a quantity of bioactive agent.Type: GrantFiled: September 8, 2017Date of Patent: March 19, 2019Assignee: Chrono Therapeutics Inc.Inventors: Zita S. Netzel, Gary Stacey, Alexander David Norman, Congyi Huang, Timothy Charles Frearson, Charles Frazer Kilby, Patrick H. Ruane, Alan J. Levy, Kevin W. Gelston, Jennifer Darmour, Jenny E. Hapgood, David Evans Roth, Ronald A. Overbeck, Ling-Kang Tong
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Patent number: 10213586Abstract: A two-part bioactive agent delivery system, the system including a disposable part comprising an agent reservoir, a bolus chamber, the volume of the bolus chamber being less than the volume of the agent reservoir, an agent outlet, and a valve having a first position communicating the agent reservoir with the bolus chamber and a second position communicating the bolus chamber with the outlet; and a reusable part including a valve driver, a power source and control electronics, the control electronics being adapted to control the valve driver to actuate the valve to deliver bioactive agent from the agent reservoir to the agent outlet; the system further having a spring extending between the agent reservoir piston and a surface of the reusable part or of the disposable part to pressurize the agent reservoir when the spring is compressed and the agent reservoir contains a quantity of bioactive agent.Type: GrantFiled: January 28, 2016Date of Patent: February 26, 2019Assignee: Chrono Therapeutics Inc.Inventors: Zita S. Netzel, Gary Stacey, Alexander David Norman, Congyi Huang, Timothy Charles Frearson, Charles Frazer Kilby, Patrick H. Ruane, Alan J. Levy, Kevin W. Gelston, Jennifer Darmour, Jenny E. Hapgood, David Evans Roth, Ronald A. Overbeck, Ling-Kang Tong
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Publication number: 20180117291Abstract: A two-part bioactive agent delivery system, the system including a disposable part comprising an agent reservoir, a bolus chamber, the volume of the bolus chamber being less than the volume of the agent reservoir, an agent outlet, and a valve having a first position communicating the agent reservoir with the bolus chamber and a second position communicating the bolus chamber with the outlet; and a reusable part including a valve driver, a power source and control electronics, the control electronics being adapted to control the valve driver to actuate the valve to deliver bioactive agent from the agent reservoir to the agent outlet; the system further having a spring extending between the agent reservoir piston and a surface of the reusable part or of the disposable part to pressurize the agent reservoir when the spring is compressed and the agent reservoir contains a quantity of bioactive agent.Type: ApplicationFiled: September 8, 2017Publication date: May 3, 2018Inventors: Zita S. NETZEL, Gary STACEY, Alexander David NORMAN, Congyi HUANG, Timothy Charles FREARSON, Charles Frazer KILBY, Patrick H. RUANE, Alan J. LEVY, Kevin W. GELSTON, Jennifer DARMOUR, Jenny E. HAPGOOD, David Evans ROTH, Ronald A. OVERBECK, Ling-Kang TONG
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Publication number: 20160220798Abstract: A two-part bioactive agent delivery system, the system including a disposable part comprising an agent reservoir, a bolus chamber, the volume of the bolus chamber being less than the volume of the agent reservoir, an agent outlet, and a valve having a first position communicating the agent reservoir with the bolus chamber and a second position communicating the bolus chamber with the outlet; and a reusable part including a valve driver, a power source and control electronics, the control electronics being adapted to control the valve driver to actuate the valve to deliver bioactive agent from the agent reservoir to the agent outlet; the system further having a spring extending between the agent reservoir piston and a surface of the reusable part or of the disposable part to pressurize the agent reservoir when the spring is compressed and the agent reservoir contains a quantity of bioactive agent.Type: ApplicationFiled: January 28, 2016Publication date: August 4, 2016Inventors: Zita S. NETZEL, Gary STACEY, Alexander David NORMAN, Congyi HUANG, Timothy Charles FREARSON, Charles Frazer KILBY, Patrick H. RUANE, Alan J. LEVY, Kevin W. GELSTON, Jennifer DARMOUR, Jenny E. HAPGOOD, David Evans ROTH, Ronald A. OVERBECK, Ling-Kang TONG
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Publication number: 20120316630Abstract: The following disclosure describes several methods and apparatus for intracranial electrical stimulation to treat or otherwise effectuate a change in neural-functions of a patient. The methods in accordance with the invention can be used to treat brain damage (e.g., stroke, trauma, etc.), brain disease (e.g., Alzheimer's, Pick's, Parkinson's, etc.), and/or brain disorders (e.g., epilepsy, depression, etc.). The methods in accordance with the invention can also be used to enhance neural-function of normal, healthy brains (e.g., learning, memory, etc.), or to control sensory functions (e.g., pain).Type: ApplicationFiled: August 16, 2012Publication date: December 13, 2012Inventors: Andrew D. Firlik, Jeffrey Balzer, Bradford Evan Gliner, Alan J. Levy, Carlton B. Morgan, Katrina S. Firlik
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Publication number: 20120253442Abstract: A device and method for intracranial electrical stimulation to effectuate a change in neural-functions of a patient, by electrical stimulating the brain at a site where neuroplasticity is occurring or is expected to occur, where the stimulation site may be different than the region in the brain where neural activity is typically present to perform the particular neural function according to the functional organization of the brain. In one embodiment in which neuroplasticity is related to the neural-function occurs in the brain, identifying the location where such neuroplasticity is present or expected to occur. Where neuroplasticity is not occurring in the brain, an alternative aspect is to induce neuroplasticity at a stimulation site where it is expected to occur. The methods can use electrical pulses that increase the resting membrane potential of neurons at the stimulation site to a subthreshold level.Type: ApplicationFiled: April 3, 2012Publication date: October 4, 2012Inventors: Bradford Evan Gliner, Brad Fowler, Andrew D. Firlik, Jeffrey Balzer, Alan J. Levy, Kent Leyde
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Publication number: 20120022611Abstract: The following disclosure describes several methods and apparatus for intracranial electrical stimulation to treat or otherwise effectuate a change in neural-functions of a patient. The methods in accordance with the invention can be used to treat brain damage (e.g., stroke, trauma, etc.), brain disease (e.g., Alzheimer's, Pick's, Parkinson's, etc.), and/or brain disorders (e.g., epilepsy, depression, etc.). The methods in accordance with the invention can also be used to enhance neural-function of normal, healthy brains (e.g., learning, memory, etc.), or to control sensory functions (e.g., pain).Type: ApplicationFiled: September 22, 2011Publication date: January 26, 2012Applicant: ADVANCED NEUROMODULATION SYSTEMS, INC.Inventors: Andrew D. Firlik, Jeffrey Balzer, Bradford Evan Gliner, Alan J. Levy, Carlton B. Morgan, Katrina S. Firlik
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Patent number: 8065012Abstract: Disclosed are several apparatuses and methods for applying intracranial electrical stimulation to treat or enhance the neural function of the patient. In accordance with the invention, intracranial electrical stimulation can be administered to treat brain damage, brain disease, and/or brain disorders. Additionally the intracranial electrical stimulation can be applied to a normal healthy brain to enhance neural-function or control sensory functions. The electrical stimulation site(s) of the brain are located where neuroplasticity is occurring, expected to occur, or in a region where neuroplasticity is not occurring. The intracranial stimulation is expected to produce a lasting effect on the intended neural activity by applying subthreshold stimulation to the increasing the resting membrane potential of the neurons at the stimulation site.Type: GrantFiled: August 6, 2007Date of Patent: November 22, 2011Assignee: Advanced Neuromodulation Systems, Inc.Inventors: Andrew D. Firlik, Jeffrey Balzer, Bradford Evan Gliner, Alan J. Levy, Carlton B. Morgan, Katrina S. Firlik
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Patent number: 8050768Abstract: The present disclosure is directed generally to methods and apparatus for effectuating a change in a neural function of a patient. A method in accordance with a particular embodiment includes implanting an electrode at a cortical stimulation site selected to promote recovery of the affected neural-function, with the cortical stimulation site being at least proximate to the cortex. The method can further include estimating a threshold for the specific patient at which an electrical signal delivered via the implanted electrode directly triggers a neural reaction associated with the stimulation site in response to the delivered electrical signal, and electrically stimulating the cortical stimulation site by passing an electrical current through the electrode.Type: GrantFiled: December 23, 2008Date of Patent: November 1, 2011Assignee: Advanced Neuromodulation Systems, Inc.Inventors: Andrew D. Firlik, Bradford Evan Gliner, Alan J. Levy, Katrina S. Firlik
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Patent number: 8019425Abstract: Methods and apparatus for treating an impaired neural function in a brain of a patient. In one embodiment, a method for treating a neural function in a brain of a patient includes determining a therapy period during which a plurality of therapy sessions are to be performed to recover functional ability corresponding to the neural function. The method continues by identifying a stimulation site in or on the brain of the patient associated with the neural function, and positioning an electrode at least proximate to the identified stimulation site. The patient is then treated by providing electrical stimulation treatments to the stimulation site. The treatment can comprise delivering electrical stimulation signals to the electrode during the therapy sessions. After expiration of the therapy period, the method includes preventing electrical stimulation signals from being delivered to the stimulation site.Type: GrantFiled: December 23, 2008Date of Patent: September 13, 2011Assignee: Advanced Neuromodulation Systems, Inc.Inventors: Andrew D. Firlik, Jeffrey Balzer, Alan J. Levy, Bradford Evan Gliner, Katrina S. Firlik
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Publication number: 20100274305Abstract: The following disclosure describes several methods and apparatus for stimulating cells implanted in the regions of nervous system, such as the brain, spinal cord or peripheral nerves. Accordingly, the functionality of the cells can be improved, for example, by differentiating undifferentiated or partially undifferentiated cells into neurons or other cells having action potentials. The method can also include promoting directional growth and connectivity of fully differentiated neural cells implanted in a patient's nervous system through electrical enhancement, for example, electrical stimulation via an anode and cathode. Methods in accordance with the invention can be used to treat brain damage (e.g., stroke, trauma, etc.), brain disease (e.g., Alzheimer's, Pick's, Parkinson's, etc.), and/or brain disorders (e.g., epilepsy, depression, etc.). The methods in accordance with the invention can also be used to enhance neural-function of normal, healthy brains (e.g., learning, memory, etc.Type: ApplicationFiled: April 30, 2010Publication date: October 28, 2010Inventors: Bradford Evan Gliner, Alan J. Levy, Jeffrey Balzer, Andrew D. Firlik, W. Doughlas Sheffield
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Publication number: 20100145427Abstract: The following disclosure describes several methods and apparatus for intracranial electrical stimulation to treat or otherwise effectuate a change in neural-functions of a patient. Certain embodiments of methods in accordance with the invention electrically stimulate the brain at a stimulation site where neuroplasticity is occurring or is expected to occur. The stimulation site may be different than the region in the brain where neural activity is typically present to perform the particular neural function according to the functional organization of the brain. In one embodiment in which neuroplasticity related to the neural-function occurs in the brain, the method can include identifying the location where such neuroplasticity is present or expected to occur. In an alternative embodiment in which neuroplasticity is not occurring in the brain, an alternative aspect is to induce neuroplasticity at a stimulation site where it is expected to occur.Type: ApplicationFiled: February 23, 2010Publication date: June 10, 2010Applicant: ADVANCED NEUROMODULATION SYSTEMS, INC.Inventors: Bradford Evan Gliner, Brad Fowler, Andrew D. Firlik, Jeffrey Balzer, Alan J. Levy, Kent Leyde
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Publication number: 20100131030Abstract: The present disclosure is directed generally to methods and apparatus for effectuating a change in a neural function of a patient. A method in accordance with a particular embodiment includes implanting an electrode at a cortical stimulation site selected to promote recovery of the affected neural-function, with the cortical stimulation site being at least proximate to the cortex. The method can further include estimating a threshold for the specific patient at which an electrical signal delivered via the implanted electrode directly triggers a neural reaction associated with the stimulation site in response to the delivered electrical signal, and electrically stimulating the cortical stimulation site by Passing an electrical current through the electrode.Type: ApplicationFiled: February 2, 2010Publication date: May 27, 2010Applicant: ADVANCED NEUROMODULATION SYSTEMS, INC.Inventors: Andrew D. Firlik, Bradford Evan Gliner, Alan J. Levy, Katrina S. Firlik
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Patent number: 7672730Abstract: Methods and apparatus for treating an impaired neural function in a brain of a patient. In one embodiment, a method for treating a neural function in a brain of a patient includes determining a therapy period during which a plurality of therapy sessions are to be performed to recover functional ability corresponding to the neural function. The method continues by identifying a stimulation site in or on the brain of the patient associated with the neural function, and positioning an electrode at least proximate to the identified stimulation site. The patient is then treated by providing electrical stimulation treatments to the stimulation site. The treatment can comprise delivering electrical stimulation signals to the electrode during the therapy sessions. After expiration of the therapy period, the method includes preventing electrical stimulation signals from being delivered to the stimulation site.Type: GrantFiled: June 24, 2003Date of Patent: March 2, 2010Assignee: Advanced Neuromodulation Systems, Inc.Inventors: Andrew D. Firlik, Jeffrey Balzer, Bradford Evan Gliner, Alan J. Levy
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Publication number: 20090319000Abstract: The present disclosure is directed generally to methods and apparatus for effectuating a change in a neural function of a patient. A method in accordance with a particular embodiment includes implanting an electrode at a cortical stimulation site selected to promote recovery of the affected neural-function, with the cortical stimulation site being at least proximate to the cortex. The method can further include estimating a threshold for the specific patient at which an electrical signal delivered via the implanted electrode directly triggers a neural reaction associated with the stimulation site in response to the delivered electrical signal, and electrically stimulating the cortical stimulation site by Passing an electrical current through the electrode.Type: ApplicationFiled: December 23, 2008Publication date: December 24, 2009Inventors: Andrew D. Firlik, Bradford Evan Gliner, Alan J. Levy, Katrina S. Firlik
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Patent number: 7577481Abstract: The following disclosure describes a method for intracranial electrical stimulation to treat or otherwise effectuate a change in neural-functions of a patient. Several embodiments are directed toward enhancing or otherwise inducing a lasting change in neural activity to effectuate a particular neural-function. Such lasting change in neural activity is defined as “neuroplasticity.” The methods can be used to treat brain damage (e.g., stroke, trauma, etc.), brain disease (e.g., Alzheimer's, Pick's, Parkinson's, etc.), and/or brain disorders (e.g., epilepsy, depression, etc.). The methods can also be used to enhance neural-function of normal, healthy brains (e.g., learning, memory, etc.), or to control sensory functions (e.g., pain).Type: GrantFiled: February 15, 2006Date of Patent: August 18, 2009Assignee: Advanced Neuromodulation Systems, Inc.Inventors: Andrew D. Firlik, Jeffrey Balzer, Bradford Evan Gliner, Alan J. Levy, Carlton B. Morgan, Katrina S. Firlik
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Publication number: 20090171416Abstract: Methods and apparatus for treating an impaired neural function in a brain of a patient. In one embodiment, a method for treating a neural function in a brain of a patient includes determining a therapy period during which a plurality of therapy sessions are to be performed to recover functional ability corresponding to the neural function. The method continues by identifying a stimulation site in or on the brain of the patient associated with the neural function, and positioning an electrode at least proximate to the identified stimulation site. The patient is then treated by providing electrical stimulation treatments to the stimulation site. The treatment can comprise delivering electrical stimulation signals to the electrode during the therapy sessions. After expiration of the therapy period, the method includes preventing electrical stimulation signals from being delivered to the stimulation site.Type: ApplicationFiled: December 23, 2008Publication date: July 2, 2009Inventors: Andrew D. Firlik, Jeffrey Balzer, Alan J. Levy, Bradford Evan Gliner, Katrina S. Firlik