Patents by Inventor Alan J. Polito
Alan J. Polito has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20130137189Abstract: An embodiment of the present invention provides a method for performing a lateral flow assay. The method includes depositing a sample on a test strip at an application region, detecting a first detection signal arising from the test strip in the first detection zone, and generating a baseline for the first measurement zone by interpolating between values of the detection signal outside of the first measurement zone and inside of the first detection zone. The method may include locating a beginning boundary and an ending boundary for the first measurement zone on the test strip. Additional detection zones having measurement zones may also be incorporated with the embodiment.Type: ApplicationFiled: January 18, 2013Publication date: May 30, 2013Applicant: Relia Diagnostic Systems, Inc.Inventors: Alan J. Polito, Richard M. Thayer, Robert K. DiNello, George H. Sierra, Dennis Nixon, Alan Phillips, Stuart Neubarth
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Patent number: 8354270Abstract: An embodiment of the present invention provides a-method for performing a lateral flow assay. The method includes depositing a sample on a test strip at an application region, detecting a first detection signal arising from the test strip in the first detection zone, and generating a baseline for the first measurement zone by interpolating between values of the detection signal outside of the first measurement zone and inside of the first detection zone. The method may include locating a beginning boundary and an ending boundary for the first measurement zone on the test strip. Additional detection zones having measurement zones may also be incorporated with the embodiment.Type: GrantFiled: October 8, 2007Date of Patent: January 15, 2013Assignee: Relia Diagnostic SystemsInventors: Alan J. Polito, Richard M. Thayer, Robert K. Dinello, George H. Sierra, Dennis Nixon, Alan Phillips, Stuart Neubarth
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Publication number: 20120064637Abstract: A test strip and method for detecting an analyte present in a sample.Type: ApplicationFiled: June 3, 2011Publication date: March 15, 2012Applicant: Relia Diagnostic Systems, Inc.Inventors: Robert K. Dinello, Alan J. Polito, Stella Quan
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Patent number: 7955791Abstract: A test strip and method for detecting an analyte present in a sample.Type: GrantFiled: April 20, 2009Date of Patent: June 7, 2011Assignee: Relia Diagnostic SystemsInventors: Robert K. Dinello, Alan J. Polito, Stella Quan
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Publication number: 20090257915Abstract: A test strip and method for detecting an analyte present in a sample.Type: ApplicationFiled: April 20, 2009Publication date: October 15, 2009Applicant: RELIA DIAGNOSTIC SYSTEMS, INC.Inventors: Robert K. Dinello, Alan J. Polito, Stella S. Quan
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Patent number: 7521196Abstract: A test strip and method for detecting an analyte present in a sample.Type: GrantFiled: June 7, 2007Date of Patent: April 21, 2009Assignee: ReLia Diagnostic Systems, LLCInventors: Robert K. Dinello, Alan J. Polito, Stella Quan
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Patent number: 7309611Abstract: A test strip and method for detecting an analyte present in a sample.Type: GrantFiled: June 14, 2004Date of Patent: December 18, 2007Assignee: Relia Diagnostic Systems, LLCInventors: Robert K. DiNello, Alan J. Polito, Stella S. Quan
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Patent number: 7297529Abstract: An embodiment of the present invention provides a method for performing a lateral flow assay. The method includes depositing a sample on a test strip at an application region, detecting a first detection signal arising from the test strip in the first detection zone, and generating a baseline for the first measurement zone by interpolating between values of the detection signal outside of the first measurement zone and inside of the first detection zone. The method may include locating a beginning boundary and an ending boundary for the first measurement zone on the test strip. Additional detection zones having measurement zones may also be incorporated with the embodiment.Type: GrantFiled: August 4, 2003Date of Patent: November 20, 2007Assignee: Relia Diagnostic Systems, LLCInventors: Alan J. Polito, Richard M. Thayer, Robert K. DiNello, George H. Sierra, Dennis Nixon, Alan Phillips, Stuart Neubarth
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Patent number: 7229839Abstract: A test strip adapted to receive a sample and detect an analyte therein is provided. The test strip comprises a sample addition zone to which a sample may be added; an absorbent zone proximal to the sample addition zone; one or more test zones distal to the sample addition zone, at least one of the test zones including a first analyte binding agent immobilized therein which is capable of binding to the analyte to be detected; and a terminal sample flow zone distal to the one or more test zones, the absorbent zone being positioned relative to the sample addition zone and having an absorption capacity relative to the other zones of the test strip such that a distal diffusion front of a sample added to the sample addition zone diffuses from the sample addition zone to a distal diffusion point within the terminal sample flow zone and then reverses direction and diffuses proximal relative to the one or more test zones.Type: GrantFiled: January 17, 2003Date of Patent: June 12, 2007Assignee: Relia Diagnostic Systems, LLCInventors: Richard M. Thayer, Alan J. Polito, Robert K. Dinello, George H. Sierra, Henry J. Wieck
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Publication number: 20040241882Abstract: A test strip and method for detecting an analyte present in a sample.Type: ApplicationFiled: June 14, 2004Publication date: December 2, 2004Applicant: PRAXSYS BIOSYSTEMS, LLC.Inventors: Robert K. DiNello, Alan J. Polito, Stella S. Quan
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Patent number: 6767710Abstract: A test strip and method for detecting an analyte present in a sample.Type: GrantFiled: March 30, 2001Date of Patent: July 27, 2004Assignee: PraxSys BioSystems, LLCInventors: Robert K. DiNello, Alan J. Polito, Stella S. Quan
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Publication number: 20040018637Abstract: An embodiment of the present invention provides a method for performing a lateral flow assay. The method includes depositing a sample on a test strip at an application region, detecting a first detection signal arising from the test strip in the first detection zone, and generating a baseline for the first measurement zone by interpolating between values of the detection signal outside of the first measurement zone and inside of the first detection zone. The method may include locating a beginning boundary and an ending boundary for the first measurement zone on the test strip. Additional detection zones having measurement zones may also be incorporated with the embodiment.Type: ApplicationFiled: March 19, 2003Publication date: January 29, 2004Inventors: Alan J. Polito, Richard M. Thayer, Robert K. DiNello, George H. Sierra, Dennis Nixon, Alan Phillips, Stuart Neubarth
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Publication number: 20030157729Abstract: A test strip adapted to receive a sample and detect an analyte therein is provided. The test strip comprises a sample addition zone to which a sample may be added; an absorbent zone proximal to the sample addition zone; one or more test zones distal to the sample addition zone, at least one of the test zones including a first analyte binding agent immobilized therein which is capable of binding to the analyte to be detected; and a terminal sample flow zone distal to the one or more test zones, the absorbent zone being positioned relative to the sample addition zone and having an absorption capacity relative to the other zones of the test strip such that a distal diffusion front of a sample added to the sample addition zone diffuses from the sample addition zone to a distal diffusion point within the terminal sample flow zone and then reverses direction and diffuses proximal relative to the one or more test zones.Type: ApplicationFiled: January 17, 2003Publication date: August 21, 2003Inventors: Richard M. Thayer, Alan J. Polito, Robert K. Dinello, George H. Sierra, Henry J. Wieck
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Patent number: 6528323Abstract: A test strip adapted to receive a sample and detect an analyte therein is provided. The test strip comprises a sample addition zone to which a sample may be added; an absorbent zone proximal to the sample addition zone; one or more test zones distal to the sample addition zone, at least one of the test zones including a first analyte binding agent immobilized therein which is capable of binding to the analyte to be detected; and a terminal sample flow zone distal to the one or more test zones, the absorbent zone being positioned relative to the sample addition zone and having an absorption capacity relative to the other zones of the test strip such that a distal diffusion front of a sample added to the sample addition zone diffuses from the sample addition zone to a distal diffusion point within the terminal sample flow zone and then reverses direction and diffuses proximal relative to the one or more test zones.Type: GrantFiled: June 14, 1999Date of Patent: March 4, 2003Assignee: Praxsys Biosystems, Inc.Inventors: Richard M. Thayer, Alan J. Polito, Robert K. Dinello, George H. Sierra, Henry J. Wieck
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Publication number: 20020173050Abstract: A test strip and method for detecting an analyte present in a sample.Type: ApplicationFiled: March 30, 2001Publication date: November 21, 2002Inventors: Robert K. DiNello, Alan J. Polito, Stella S. Quan
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Patent number: 6136610Abstract: An embodiment of the present invention provides a method for performing a lateral flow assay. The method includes depositing a sample on a test strip at an application region, detecting a first detection signal arising from the test strip in the first detection zone, and generating a baseline for the first measurement zone by interpolating between values of the detection signal outside of the first measurement zone and inside of the first detection zone. The method may include locating a beginning boundary and an ending boundary for the first measurement zone on the test strip. Additional detection zones having measurement zones may also be incorporated with the embodiment.Type: GrantFiled: November 23, 1998Date of Patent: October 24, 2000Assignee: PraxSys BioSystems, Inc.Inventors: Alan J. Polito, Richard M. Thayer, Robert K. DiNello, George H. Sierra, Dennis Nixon, Alan Phillips, Stuart Neubarth
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Patent number: 4855226Abstract: A novel competitive assay for theophylline wherein caffeine-like (7-substituted) labeled conjugates are used to detect the presence and/or amount of theophylline present in a test sample. The use of such conjugates in a competitive assay for theophylline results in improved sensitivity of the assay method. Where the assay method is a nephelometric or turbidimetric inhibition immunoassay procedure, the assay was found to be less temperature dependent than prior art immunoassays.Type: GrantFiled: June 7, 1985Date of Patent: August 8, 1989Assignee: Beckman Instruments, Inc.Inventors: Alan J. Polito, Anthony K. Cheng
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Patent number: 4347059Abstract: A T.sub.3 uptake polarization fluoroimmunoassay where a sample is assayed by contacting a serum sample with T.sub.3 to form a solution, contacting the solution with a separating agent and incubating the same, separating T.sub.3 bound to the separating agent from the serum sample, contacting the T.sub.3 bound to the separating agent with an antibody against T.sub.3, incubating and separating the agent-anti-body combination, separating free anti-body and contacting the free antibody with fluorescent labeled T.sub.3 and fluorometrically measuring the fluorescence polarization.Type: GrantFiled: September 15, 1980Date of Patent: August 31, 1982Assignee: Beckman Instruments, Inc.Inventors: Alan J. Polito, Kurtis R. Bray
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Patent number: 4347058Abstract: A polarization fluoroimmunoassay for T.sub.3 or T.sub.4 thyroid hormones where a serum sample is assayed by contacting the sample with a base to denature the thyroxine binding globulins and thereby form a solution, incubating the solution, contacting the solution with a separating agent and separating bound thyroid hormone from the serum, contacting the separating agent with bound thyroid hormone with an antibody against the thyroid hormone, incubating the separating agent-antibody combination, separating free antibody and thyroid hormone bound antibody from the separating agent, contacting the free antibody with fluorescent labelled thyroid hormone and measuring the fluorescence polarization as an indication of the thyroid hormone in the sample.Type: GrantFiled: September 15, 1980Date of Patent: August 31, 1982Assignee: Beckman Instruments, Inc.Inventors: Alan J. Polito, Kurtis R. Bray
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Patent number: 4158703Abstract: An improved T.sub.3 uptake test procedure characterized in that the separating agent employed therein comprises bovine serum albumin covalently coupled to a derivatized polysaccharide matrix by a bifunctional coupling agent selected from a group consisting of ##STR1## WHEREIN N IS AN INTEGER FROM 1 TO 6 AND WHEREIN E IS AN INTEGER FROM 1 TO 2.A separating agent comprising bovine serum albumin covalently coupled to a derivatived polysaccharide matrix by a bifunctional coupling agent selected from a group consisting of ##STR2## WHEREIN N IS AN INTEGER FROM 1 TO 6 AND WHEREIN E IS AN INTEGER FROM 1 TO 2.Type: GrantFiled: February 13, 1978Date of Patent: June 19, 1979Assignee: Beckman Instruments, Inc.Inventor: Alan J. Polito