Patents by Inventor Alan J. Tackett

Alan J. Tackett has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and kits for isolation and analysis of a chromatin region
    Patent number: 10209247
    Abstract: The present invention encompasses methods of identifying proteins and protein modifications of proteins specifically associated with a chromatin.
    Type: Grant
    Filed: August 3, 2016
    Date of Patent: February 19, 2019
    Assignee: BioVentures, LLC
    Inventors: Alan J. Tackett, Stephanie Byrum, Sean Taverna, Kevin Raney, Zachary Waldrip
  • Methods and kits for isolation and analysis of a chromatin region
    Patent number: 9863957
    Abstract: The present invention encompasses methods of identifying proteins and protein modifications of proteins specifically associated with a chromatin.
    Type: Grant
    Filed: February 1, 2016
    Date of Patent: January 9, 2018
    Assignee: BIOVENTURES, LLC
    Inventors: Alan J. Tackett, Stephanie Byrum, Sean Taverna
  • Methods and kits for isolation and analysis of a chromatin region
    Patent number: 9506915
    Abstract: The present invention encompasses methods of identifying proteins and protein modifications of proteins specifically associated with a chromatin.
    Type: Grant
    Filed: June 19, 2015
    Date of Patent: November 29, 2016
    Assignee: BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS
    Inventors: Alan J. Tackett, Stephanie Byrum, Sean Taverna, Kevin Raney, Zachary Waldrip
  • METHODS AND KITS FOR ISOLATION AND ANALYSIS OF A CHROMATIN REGION
    Publication number: 20160334415
    Abstract: The present invention encompasses methods of identifying proteins and protein modifications of proteins specifically associated with a chromatin.
    Type: Application
    Filed: August 3, 2016
    Publication date: November 17, 2016
    Applicant: Board of Trustees of the University of Arkansas
    Inventors: Alan J. Tackett, Stephanie Byrum, Sean Taverna, Kevin Raney, Zachary Waldrip
  • METHODS AND KITS FOR ISOLATION AND ANALYSIS OF A CHROMATIN REGION
    Publication number: 20160223561
    Abstract: The present invention encompasses methods of identifying proteins and protein modifications of proteins specifically associated with a chromatin.
    Type: Application
    Filed: February 1, 2016
    Publication date: August 4, 2016
    Applicant: Board of Trustees of the University of Arkansas
    Inventors: Alan J. Tackett, Stephanie Byrum, Sean Taverna
  • Methods and kits for isolation and analysis of a chromatin region
    Patent number: 9279816
    Abstract: The present invention encompasses methods of identifying proteins and protein modifications of proteins specifically associated with a chromatin.
    Type: Grant
    Filed: November 15, 2013
    Date of Patent: March 8, 2016
    Assignee: BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS
    Inventors: Alan J. Tackett, Stephanie Byrum, Sean Taverna
  • METHODS AND KITS FOR ISOLATION AND ANALYSIS OF A CHROMATIN REGION
    Publication number: 20150338398
    Abstract: The present invention encompasses methods of identifying proteins and protein modifications of proteins specifically associated with a chromatin.
    Type: Application
    Filed: June 19, 2015
    Publication date: November 26, 2015
    Applicant: BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS
    Inventors: Alan J. Tackett, Stephanie Byrum, Sean Taverna, Kevin Raney, Zachary Waldrip
  • METHODS AND KITS FOR ISOLATION AND ANALYSIS OF A CHROMATIN REGION
    Publication number: 20140154674
    Abstract: The present invention encompasses methods of identifying proteins and protein modifications of proteins specifically associated with a chromatin.
    Type: Application
    Filed: November 15, 2013
    Publication date: June 5, 2014
    Applicant: Board of Trustees of University of Arkansas
    Inventors: Alan J. Tackett, Stephanie Byrum, Sean Taverna
  • Methods and kits for quantitative methyltransferase and demethylase measurements
    Patent number: 8367366
    Abstract: The invention provides methods and kits for characterizing the activity of a methyltransferase or demethylase. The method involves enzymatically methylating or demethylating in vitro a substrate that is a peptide fragment of a full-length polypeptide, and then non-enzymatically methylating the peptide substrate with methyl groups that differ in molecular weight from the enzymatically added or removed methyl groups. Typically, deuterated or 13C formaldehyde is used to non-enzymatically methylate the substrate. The fully methylated substrate is then characterized by mass spectrometry to determine the ratio of enzymatically produced nonmethyl, monomethyl, and dimethyl residues on the peptide.
    Type: Grant
    Filed: December 4, 2010
    Date of Patent: February 5, 2013
    Assignee: The Board of Trustees of the University of Arkansas
    Inventors: Alan J. Tackett, Nathan L. Avaritt, Lauren P. Blair
  • Methods and kits for distinguishing between specific and non-specific protein associations
    Patent number: 8227198
    Abstract: The present invention is method of determining whether or not associations between a given protein and other proteins in a cell are specific.
    Type: Grant
    Filed: May 12, 2011
    Date of Patent: July 24, 2012
    Assignee: The Rockefeller University
    Inventors: Brian T. Chait, Alan J. Tackett, Jeffrey A. DeGrasse, Marlene Oeffinger, Michael P. Rout, Matthew D. Sekedat
  • Methods and Kits for Quantitative Methyltransferase and Demethylase Measurements
    Publication number: 20120142040
    Abstract: The invention provides methods and kits for characterizing the activity of a methyltransferase or demethylase. The method involves enzymatically methylating or demethylating in vitro a substrate that is a peptide fragment of a full-length polypeptide, and then non-enzymatically methylating the peptide substrate with methyl groups that differ in molecular weight from the enzymatically added or removed methyl groups. Typically, deuterated or 13C formaldehyde is used to non-enzymatically methylate the substrate. The fully methylated substrate is then characterized by mass spectrometry to determine the ratio of enzymatically produced nonmethyl, monomethyl, and dimethyl residues on the peptide.
    Type: Application
    Filed: December 4, 2010
    Publication date: June 7, 2012
    Inventors: Alan J. Tackett, Nathan L. Avaritt, Lauren P. Blair
  • Methods and Kits for Distinguishing Between Specific and Non-Specific Protein Associations
    Publication number: 20110217718
    Abstract: The present invention is method of determining whether or not associations between a given protein and other proteins in a cell are specific.
    Type: Application
    Filed: May 12, 2011
    Publication date: September 8, 2011
    Applicant: THE ROCKEFELLER UNIVERSITY
    Inventors: Brian T. Chait, Alan J. Tackett, Jeffrey A. DeGrasse, Marlene Oeffinger, Michael P. Rout, Matthew D. Sekedat
  • Methods and kits for distinguishing between specific and non-specific protein associations
    Patent number: 7968299
    Abstract: The present invention is method of determining whether or not associations between a given protein and other proteins in a cell are specific.
    Type: Grant
    Filed: August 21, 2006
    Date of Patent: June 28, 2011
    Assignee: The Rockefeller University
    Inventors: Brian T. Chait, Alan J. Tackett, Jeffrey A. DeGrasse, Marlene Oeffinger, Michael P. Rout, Matthew D. Sekedat
  • Kit for assaying acetyl transferase or deacetylase activity
    Patent number: 7851175
    Abstract: The invention provides methods and kits for characterizing the activity of an acetyl transferase or deacetylase. The method involves enzymatically acetylating or deacetylating in vitro a substrate that is a peptide fragment of a full-length polypeptide, and then non-enzymatically acylating the peptide substrate with acyl groups that differ in molecular weight from the enzymatically added or removed acetyl groups. Typically, deuterated acetic anhydride is used to non-enzymatically acylate the substrate. The fully acylated substrate is then characterized by mass spectrometry to determine the amino acid positions of the substrate that are enzymatically acetylated or deacetylated.
    Type: Grant
    Filed: October 13, 2009
    Date of Patent: December 14, 2010
    Assignees: The Board of Trustees of the University of Arkansas, The Rockefeller University
    Inventors: Alan J. Tackett, C. David Allis, Sean D. Taverna
  • Methods for assaying acetyl transferase or deacetylase activity
    Patent number: 7670795
    Abstract: The invention provides methods and kits for characterizing the activity of an acetyl transferase or deacetylase. The method involves enzymatically acetylating or deacetylating in vitro a substrate that is a peptide fragment of a full-length polypeptide, and then non-enzymatically acylating the peptide substrate with acyl groups that differ in molecular weight from the enzymatically added or removed acetyl groups. Typically, deuterated acetic anhydride is used to non-enzymatically acylate the substrate. The fully acylated substrate is then characterized by mass spectrometry to determine the amino acid positions of the substrate that are enzymatically acetylated or deacetylated.
    Type: Grant
    Filed: June 12, 2007
    Date of Patent: March 2, 2010
    Inventors: Alan J. Tackett, C. David Allis, Sean D. Taverna
  • Methods and kits for assaying acetyl transferase or deacetylase activity
    Publication number: 20100041085
    Abstract: The invention provides methods and kits for characterizing the activity of an acetyl transferase or deacetylase. The method involves enzymatically acetylating or deacetylating in vitro a substrate that is a peptide fragment of a full-length polypeptide, and then non-enzymatically acylating the peptide substrate with acyl groups that differ in molecular weight from the enzymatically added or removed acetyl groups. Typically, deuterated acetic anhydride is used to non-enzymatically acylate the substrate. The fully acylated substrate is then characterized by mass spectrometry to determine the amino acid positions of the substrate that are enyzmatically acetylated or deacetylated.
    Type: Application
    Filed: October 13, 2009
    Publication date: February 18, 2010
    Inventors: Alan J. Tackett, C. David Allis, Sean D. Taverna
  • Methods and kits for assaying acetyl transferase or deacetylase activity
    Publication number: 20090061469
    Abstract: The invention provides methods and kits for characterizing the activity of an acetyl transferase or deacetylase. The method involves enzymatically acetylating or deacetylating in vitro a substrate that is a peptide fragment of a full-length polypeptide, and then non-enzymatically acylating the peptide substrate with acyl groups that differ in molecular weight from the enzymatically added or removed acetyl groups. Typically, deuterated acetic anhydride is used to non-enzymatically acylate the substrate. The fully acylated substrate is then characterized by mass spectrometry to determine the amino acid positions of the substrate that are enzymatically acetylated or deacetylated.
    Type: Application
    Filed: June 12, 2007
    Publication date: March 5, 2009
    Inventors: Alan J. Tackett, C. David Allis, Sean D. Taverna