Abstract: Disclosed herein are methods for treating neuropathic pain in a subject in need thereof. The methods include: administering to a subject in need thereof a therapeutically effective amount of an antagonist of P2Y14.

Abstract: Disclosed herein are methods for treating neuropathic pain in a subject in need thereof. The methods include: administering to a subject in need thereof a therapeutically effective amount of an antagonist of P2Y14.

Abstract: Adenosine kinase inhibitors, including pharmaceutical compositions containing the adenosine kinase inhibitors, and their use for preventing epilepsy and its progression in patients. The adenosine kinase inhibitors have the formula: where the moieties J and K, considered in combination, are —CH2—, or K and L, considered in combination, are —CH2—. The R1 moiety can be —NH2, C1-C6 alkyl, C1-C6 alkoxy, or C1-C6 hydroxyalkyl. The R2 and R3 moieties are each independently C1-C6 alkyl. The R4 moiety is hydrogen or C1-C6 alkyl. The R5 and R6 moieties are each independently C6-C12 aryl, C3-C8 cycloalkyl, or C3-C8 heteroaryl, that is optionally further substituted.

Abstract: Disclosed are apparatus, systems, and methods for determining the completeness of the cement sheath or gravel-pack annulus of a borehole based on gamma counts or count rates measured with a pulsed neuron tool deployed in the borehole in conjunction with a quantitative relationship between certain gamma count (rate) ratios and a parameter of completeness. In various embodiments, the determination utilizes the ratio of the net long inelastic count (rate) and the near capture count (rate), or the ratio of the net near inelastic count (rate) and the long capture count (rate). Additional apparatus, systems, and methods are disclosed.

Abstract: Adenosine kinase inhibitors, including pharmaceutical compositions containing the adenosine kinase inhibitors, and their use for preventing epilepsy and its progression in patients. The adenosine kinase inhibitors have the formula: where the moieties J and K, considered in combination, are —CH2—, or K and L, considered in combination, are —CH2—. The R1 moiety can be —NH2, C1-C6 alkyl, C1-C6 alkoxy, or C1-C6 hydroxyalkyl. The R2 and R3 moieties are each independently C1-C6 alkyl. The R4 moiety is hydrogen or C1-C6 alkyl. The R5 and R6 moieties are each independently C6-C12 aryl, C3-C8 cycloalkyl, or C3-C8 heteroaryl, that is optionally further substituted.

Abstract: Disclosed are apparatus, systems, and methods for determining the completeness of the cement sheath or gravel-pack annulus of a borehole based on gamma counts or count rates measured with a pulsed neuron tool deployed in the borehole in conjunction with a quantitative relationship between certain gamma count (rate) ratios and a parameter of completeness. In various embodiments, the determination utilizes the ratio of the net long inelastic count (rate) and the near capture count (rate), or the ratio of the net near inelastic count (rate) and the long capture count (rate). Additional apparatus, systems, and methods are disclosed.

Abstract: Adenosine kinase inhibitors, including pharmaceutical compositions containing the adenosine kinase inhibitors, and their use for preventing epilepsy and its progression in patients. The adenosine kinase inhibitors have the formula: where the moieties J and K, considered in combination, are —CH2—, or K and L, considered in combination, are —CH2—. The R1 moiety can be —NH2, C1-C6 alkyl, C1-C6 alkoxy, or C1-C6 hydroxyalkyl. The R2 and R3 moieties are each independently C1-C6 alkyl. The R4 moiety is hydrogen or C1-C6 alkyl. The R5 and R6 moieties are each independently C6-C12 aryl, C3-C8 cycloalkyl, or C3-C8 heteroaryl, that is optionally further substituted.

Abstract: In some embodiments, apparatus and systems, as well as methods, may operate to irradiate a portion of a geological formation with neutrons in a neutron burst generated by a switchable electronic source, to measure (with one or more detectors) a flux of gamma rays to provide a measured flux, at least a portion of the gamma rays being generated by the neutrons, and to determine one or more of a neutron porosity, a density, and/or a photoelectric factor of the geological formation based on the measured flux. Other apparatus, systems, and methods are disclosed.

Abstract: The present invention provides methods of treating a botulinum toxin related condition in a subject. In certain embodiments, the methods involve administering a compound of the following formulas: (I), (II), (III), (IV), (V).

Abstract: The present invention provides compounds and methods for treating zinc matrix metalloprotease dependent diseases.

Abstract: The educational website is a web-driven social network that aggregates content from other sites, the content being of interest to a niche category of users. The website registers site users while collecting demographic and geographic information associated with each user. Customized user permissions over the website are allocated based on the demographic and geographic information collected. The website serves the aggregated content on at least one web page accessible to a user's display device. Advertising is delivered to the users based on the user demographic information, geographic information and permissions. In one particular embodiment, the website aggregates news items. Students and teachers are registered. The website accepts student posted comments and reviews about the news items. Advertising is targeted to the students and teachers based on their demographic and geographic information. Advertisements can be categorized as display or print and delivered to the users accordingly.

Abstract: In some embodiments, apparatus and systems, as well as methods, may operate to irradiate a portion of a geological formation (94) with neutrons in a neutron burst generated by a switchable electronic source (84), to measure (with one or more detectors (86) a flux of gamma rays to provide a measured flux, at least a portion of the gamma rays being generated by the neutrons, and to determine one one or more of a neutron porosity, a density, and/or a photoelectric factor of the geological formation based on the measured flux.

Abstract: A process of producing HPLC grade acetonitrile (UV cutoff<190) comprising a multistep distillation under reflux conditions followed by acidic ion exchange resin treatment to remove essentially all impurities from the acetonitrile.

Abstract: The present application discloses a video classified advertisement web-enabled operation combining advertisements with videos specifically designed to advertise items and services for sale. The website, www.RealPeopleRealStuff.com, combines the methodology of Drupal modules, but not limited to Drupal open source modules, creates a content data model for video ads using such as Drupal's CCK module, converts most video formats, MPEG, QuickTime, and AVI, into flash (FLV) format using such as Drupal's FFMPEG module or maintain native video format if not convertible to flash format (FLV), creates a software routine that determines the most cost effective way to download videos, moves the video storage from the hosting servers to the Simple Storage Server (S3) such as Amazon S3 servers, creates an Application programming interface (API) between the hosting and storage servers, and simultaneously or later creates a category taxonomy for grouping ads for a video classified advertisement website.

Abstract: A process of producing HPLC grade acetonitrile (UV cutoff<190) comprising a multistep distillation under reflux conditions followed by acidic ion exchange resin treatment to remove essentially all impurities from the acetonitrile.

Abstract: A turbine nozzle includes a row of vanes in corresponding segmented outer and inner bands. The inner band of each segment includes a retention flange. A nozzle support includes forward and aft flanges defining a retention slot receiving the retention flange. The retention flange includes a radial lug trapped axially in the retention slot, and a tangential lug at an opposite circumferential end disposed on the forward flange. The aft flange includes an outer hinge, and the retention flange further includes an inner hinge for cradle mounting the retention flange in the nozzle support.

Abstract: A turbine nozzle includes a row of vanes in corresponding segmented outer and inner bands. The inner band of each segment includes a retention flange. A nozzle support includes forward and aft flanges defining a retention slot receiving the retention flange. The retention flange includes a radial lug trapped axially in the retention slot, and a tangential lug at an opposite circumferential end disposed on the forward flange. The aft flange includes an outer hinge, and the retention flange further includes an inner hinge for cradle mounting the retention flange in the nozzle support.

Abstract: The method of the present invention comprises feeding crude acetonitrile containing acrylonitrile as an impurity and water into the upper portion of a distillation column, distilling the crude acetonitrile in the presence of the water for a time sufficient to allow substantially all of the acrylonitrile impurity to be vaporized in the presence of the water, removing substantially all of the acrylonitrile in an overhead stream exiting from the distillation column and recovering the crude acetonitrile substantially free of acrylonitrile impurity from the lower portion of the distillation column. In particular, the method can be utilized to produce HPLC grade acetonitrile (UV cutoff <190).