Abstract: A method of controlling an occupant microclimate environment includes determining a heat balance on an occupant in a microclimate environment based upon a thermal model of the heat transfer effects on the occupant, estimating an overall thermal sensation of the occupant based upon the heat balance, referencing a target overall thermal sensation of the occupant, calculating an error between the estimated overall thermal sensation and the target overall thermal sensation, and controlling at least one thermal effector in at least one zone in the microclimate environment to reduce the error in overall thermal sensation while maintaining all effectors within limits of temperature and flow rate that ensure occupant comfort.

Abstract: Hydraulic control circuits, couplers with hydraulic control circuits, and methods for controlling couplers that include a safety knuckle for retaining a first pin and a tongue for retaining a second pin, the safety knuckle automatically resetting upon removal of the safety pin.

Abstract: A sampling system is provided for sampling fluids flowing through a pipe. The system includes at least two accumulator vessels; a single sampling pump for collection of samples and delivering samples via sampling lines to one or more of the at least two accumulators; one or more product valves associated with each of the accumulator vessels actuatable to direct sample flow to a particular accumulator vessel depending on the status of each of the at least two accumulator vessels; and a control system in connection with the sampling pump, product valves and accumulator vessels for automation of the pumping of samples to a particular accumulator vessel, depending on status of each of the at least two accumulator vessels, to ensure consistent sample taking and accumulation. The control system and sample pump is configured to accommodate bi-directional flow of fluid travelling through the pipe.

Abstract: The present disclosure provides methods of determining the susceptibility of a dog to liver copper accumulation, comprising detecting in a biological sample obtained from the dog the presence or absence in the genome of the dog of one or more polymorphisms, and methods of treating or breeding the dog based on such determination.

Abstract: Substituted pyridazinone compounds, conjugates, and pharmaceutical compositions for use in the treatment of neuromuscular diseases, such as Duchenne Muscular Dystrophy (DMD), are disclosed herein. The disclosed compounds are useful, among other things, in the treating of DMD and modulating inflammatory inhibitors IL-1, IL-6 or TNF-?.

Abstract: An operator node is configured to enable the management of nodes communicatively coupled to the operator node via a network. A selection of node objects is received by the operator node, the selected node objects including software components for inclusion within a node configuration. A configuration policy is generated based on the selected objects, the configuration policy including a set of tests (such as scripts or executables) that, when run, test for the presence of one or more of the selected node objects. A target node is scanned to determine the configuration of the target node, and the set of tests are applied to identify a set of objects identified by the policy but not installed at the target node. The target node is then re-configured to install the identified set of objects at the target node.

Abstract: A method for avoiding packet mis-ordering when routing a flow of packets in a direct interconnect network along a path from a source node to a destination node using virtual channel FIFOs. The method involves assigning a VC FIFO buffer for an input port in the next node along the path from the source node to the destination node via a next-hop VC allocation table (NVT), which encodes VC FIFO buffer availability for all packets identified as part of the flow of packets.

Abstract: An internal network can include a plurality of linked internal nodes, each internal node being configured to communicate with other internal nodes or with one or more external servers over an external network. The internal network can analyze the configuration of the internal nodes and the network traffic between internal nodes of the internal network and external servers. Based on the analysis, a network vulnerability score measuring the vulnerability of the internal network to attack can be determined. If the vulnerability score is below a threshold, the internal network can be isolated from the external network, for example by preventing internal nodes from communicating with or over the external network.

Abstract: Provided dihydroquinazolinone and azadihydroquinazolinone compounds for treating cardiac indications such as hypertrophic cardiomyopathy and diastolic dysfunction.

Abstract: A computer-implemented method of analysing transcript data, comprising: receiving a plurality of transcripts and a set of outcome data for each transcript, the outcome data associating each transcript with one or more outcomes; receiving a query transcript; processing the query transcript and each transcript within the plurality of transcripts; comparing, the processed data representing the query transcript with the processed data representing the plurality of transcripts, to identify a subset of the plurality of transcripts that meet a threshold similarity criterion with respect to the query transcript; and thereby determining a relationship between the query transcript and one or more outcomes.

Abstract: An internal network can include a plurality of linked internal nodes, each internal node being configured to communicate with other internal nodes or with one or more external servers over an external network. The internal network can analyze the configuration of the internal nodes and the network traffic between internal nodes of the internal network and external servers. Based on the analysis, a network vulnerability score measuring the vulnerability of the internal network to attack can be determined. If the vulnerability score is below a threshold, the internal network can be isolated from the external network, for example by preventing internal nodes from communicating with or over the external network.

Abstract: A heating device includes a flexible housing that defines a plurality of heater segments. Each heater segment includes a first compartment containing a first reactant, a second compartment containing a second reactant, and a frangible seal between the first compartment and the second compartment. The first reactant and the second reactant are configured to react exothermically upon contact with one another.

Abstract: The present disclosure provides methods of determining the susceptibility of a dog to liver copper accumulation, comprising detecting in a biological sample obtained from the dog the presence or absence in the genome of the dog of one or more polymorphisms, and methods of treating or breeding the dog based on such determination.

Abstract: A device and method for determining and/or monitoring the respiratory effort of a subject are presented. The device comprises a receiving unit for receiving a posture signal of the subject, a breathing signal of the subject, and an electromyography signal of the subject; and a processing unit for determining an electromyography signal based on the posture signal and the breathing signal and for deriving the respiratory effort based on the determined electromyography signal.

Abstract: The present disclosure generally relates to substituted quinolinone amide compounds or salts of Formula (I), (II-A), (IV), or (III) and pharmaceutical compositions thereof. The substituted quinolinone amide compounds or salts of Formula (I), (II-A), (IV), or (III) disclosed herein may be used to treat or prevent cardiac disease in an individual in need thereof.

Abstract: Provided are quinazolinone dione compounds for treating cardiac indications such as hypertrophic cardiomyopathy and diastolic dysfunction.

Abstract: An electronic device will identify an electronic message received by a messaging client that is associated with a first recipient, and it will analyze the electronic message to determine whether the electronic message is a simulated malicious message. Upon determining that electronic message is a simulated malicious message, the device will identify an actuatable element in the electronic message. The actuatable element will include a service address. The device will modify the electronic message by appending a user identifier of the first recipient to the service address of the actuatable element. Then, when the actuatable element is actuated, the system may determine whether the first recipient actuated the actuatable element or an alternate recipient did so based on whether the user identifier of the first recipient is still appended (or is the only user identifier appended) to the actuatable element.

Abstract: Distributing audio signals from a plurality of audio inputs to a plurality of outputs in response to a user-defined distribution is shown. The user-defined distribution is processed by a layered stack of function matrices, each layer including a two-dimensional array of function nodes. Node functions in a layer are updated in response to user-input signals to implement functionality such as signal masking and signal routing. The user-defined distribution is transformed by processing it through the layered stack to define a transformed distribution. The layered stack facilitates comprehensive mixing facilities on low cost signal processing hardware. The transforming layers include a virtual bus-applying layer to reduce the dimensions of the transformed distribution, minimizing the cost of hardware further.

Abstract: The present invention relates to a compound that is pharmaceutically active and methods of preparation thereof. The compound of the invention is 6-hydroxy-cannabidol-C4 (6-OH-CBD-C4). The compound of the invention is related to cannabidiol (CBD). CBD is a non-psychoactive cannabinoid which has been used to treat various diseases and disorders. While such treatments hold promise, there remains a need in the art for more effective treatments and this has been brought about by way of the compound of the invention.

Abstract: Substituted pyridazinone compounds, conjugates, and pharmaceutical compositions for use in the treatment of neuromuscular diseases, such as Duchenne Muscular Dystrophy (DMD), are disclosed herein. The disclosed compounds are useful, among other things, in the treating of DMD and modulating inflammatory inhibitors IL-1, IL-6 or TNF-?.