Patents by Inventor Alan John Nadin

Alan John Nadin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Benzodiazepine derivatives as inhibitors of gamma secretase
    Patent number: 6995155
    Abstract: Compounds of formula (I) are disclosed. The compounds inhibit the action of gamma secretase, and hence find use in the treatment and prevention of Alzheimer's disease.
    Type: Grant
    Filed: August 8, 2001
    Date of Patent: February 7, 2006
    Assignee: Merck Sharp & Dohme Limited
    Inventors: Ian Churcher, Alan John Nadin, Andrew Pate Owens
  • Gamma-secretase inhibitors
    Patent number: 6984626
    Abstract: A class of compounds is disclosed which are diasteroisomers of a known class of protease inhibitors. The compound inhibit gamma-secretase, and find use in the treatment of and/or prevention of Alzheimer's disease.
    Type: Grant
    Filed: April 4, 2001
    Date of Patent: January 10, 2006
    Assignee: Merck, Sharp & Dohme Ltd.
    Inventors: Alan John Nadin, Graeme Irvine Stevenson
  • Cyclohexyl sulphones
    Patent number: 6984663
    Abstract: Novel sulphones of formula I are disclosed: The compounds modulate the processing of amyloid precursor protein by gamma-secretase, and hence are useful in the treatment or prevention of Alzheimer's disease.
    Type: Grant
    Filed: August 20, 2002
    Date of Patent: January 10, 2006
    Assignee: Merck Sharp & Dohme Limited
    Inventors: Ian Churcher, Kevin Dinnell, Timothy Harrison, Sonia Kerrad, Alan John Nadin, Paul Joseph Oakley, Duncan Edward Shaw, Martin Richard Teall, Susannah Williams, Brian John Williams
  • Cyclohexyl sulphones as gamma-secretase inhibitors
    Patent number: 6890956
    Abstract: Compounds of formula I: inhibit the processing of APP by gamma-secretase, and hence are useful in treating or preventing Alzheimer's disease.
    Type: Grant
    Filed: October 6, 2003
    Date of Patent: May 10, 2005
    Assignee: Merck Sharp & Dohme Limited
    Inventors: Ian Churcher, Timothy Harrison, Sonia Kerrad, Alan John Nadin, Andrew Pate Owens, Duncan Edward Shaw, Joanne Thomson, Susannah Williams
  • Cyclic sulfonamides for inhibition of gamma-secretase
    Publication number: 20040230054
    Abstract: Compounds of formula I: 1
    Type: Application
    Filed: May 14, 2004
    Publication date: November 18, 2004
    Inventors: Kevin Dinnell, Timothy Harrison, Alan John Nadin, Andrew Pate Owens, Duncan Edward Shaw, Brian John Williams
  • Gamma-secretase inhibitors
    Patent number: 6756511
    Abstract: Gamma-secretase inhibitors, useful in the treatment or prevention of Alzheimer's disease, are disclosed. The preferred compounds have, as the central portion of the molecule, the structure (a) and are di-astereoisomers of known protease inhibitors.
    Type: Grant
    Filed: July 18, 2002
    Date of Patent: June 29, 2004
    Assignee: Merck Sharp & Dohme Limited
    Inventors: Jose Luis Castro Pineiro, Timothy Harrison, Peter Alan Hunt, Alan John Nadin
  • Cyclohexyl sulphones as gamma-secretase inhibitors
    Publication number: 20040121995
    Abstract: Compounds of formula I: 1
    Type: Application
    Filed: October 6, 2003
    Publication date: June 24, 2004
    Inventors: Ian Churcher, Timothy Harrison, Sonia Kerrad, Alan John Nadin, Andrew Pate Owens, Duncan Edward Shaw, Joanne Thomson, Susannah Williams
  • Investigational compounds
    Patent number: 6753410
    Abstract: The present invention is directed to compounds and pharmaceutical compositions comprising the compounds which are inhibitors of the enzyme gamma secretase and which are useful in the treatment or prevention of diseases in which the beta-amyloid peptide is involved, such as Alzheimer's disease.
    Type: Grant
    Filed: March 2, 2001
    Date of Patent: June 22, 2004
    Assignee: Merck & Co., Inc.
    Inventors: Alan John Nadin, Joseph George Neduvelil, Mohinder K. Sardana, Jules A. Shafer, Stephen J. Gardell, Ming-Tain Lai, Yueming Li, Bruce D. Dorsey, Dennis C. Dean
  • Sulphones which modulate the action of gamma secretase
    Publication number: 20040116404
    Abstract: Disclosed are sulphones which modulate the action of gamma-secretase. The compounds are useful in the treatment or prevention of Alzheimer's disease.
    Type: Application
    Filed: October 1, 2003
    Publication date: June 17, 2004
    Inventors: Jose Luis Castro Pineiro, Ian Churcher, Kevin Dinnell, Timothy Harrison, Sonia Kerrad, Alan John Nadin, Paul Joseph Oakley, Andrew Pate Owens, Duncan Edward Shaw, Martin Richard Teall, Susannah William, Brian John Williams
  • Benzodiazepine derivatives as app modulators
    Publication number: 20040082572
    Abstract: A novel class of 1,4- and 1,5-benzodiazepines of formula (I) is disclosed. The compounds modulate the processing of amyloid precursor protein by &ggr;-secretase, and hence find use in the treatment or prevention of conditions associated with the deposition of &bgr;-amyloid, such as Alzheimer's disease.
    Type: Application
    Filed: November 22, 2002
    Publication date: April 29, 2004
    Inventors: Jose Luis Castro Pineiro, Ian Churcher, Alexander Richard Guiblin, Timothy Harrison, Sonia Kerrard, Andrew Madin, Alan John Nadin, Andrew Pate Owens, Timothy Jason Sparey, Martin Richard Teall, Susannah Williams
  • Sulphonamido-substituted bridged bicycloalkyl derivatives
    Publication number: 20040029862
    Abstract: A class of compounds is disclosed, comprising sulphonamido-substituted bridged bicycloalkyl structures. The compounds are inhibitors of gamma-secretase, and hence are useful in the treatment of and/or prevention of Alzheimer's disease.
    Type: Application
    Filed: February 5, 2003
    Publication date: February 12, 2004
    Inventors: Patrice Charles Belanger, Ian James Collins, Joanne Claire Hannam, Timothy Harrison, Stephen John Lewis, Andrew Madin, Edward Giles McIver, Alan John Nadin, Joseph George Neduvelil, Mark Steven Shearman, Adrian Leonard Smith, Timothy Jason Sparey, Graeme Irvine Stevenson, Martin Richard Teall
  • Benzodiazepine derivatives as inhibitors of gamma secretase
    Publication number: 20040024203
    Abstract: Compounds of formula (I) are disclosed. The compounds inhibit the action of gamma secretase, and hence find use in the treatment and prevention of Alzheimer's disease.
    Type: Application
    Filed: April 11, 2003
    Publication date: February 5, 2004
    Inventors: Ian Churcher, Alan John Nadin, Andrew Pate Owens
  • Novel cyclohexyl sulphones
    Publication number: 20030114496
    Abstract: Novel sulphones of formula I are disclosed: 1
    Type: Application
    Filed: August 20, 2002
    Publication date: June 19, 2003
    Inventors: Ian Churcher, Kevin Dinnell, Timothy Harrison, Sonia Kerrad, Alan John Nadin, Paul Joseph Oakley, Duncan Edward Shaw, Martin Richard Teall, Susannah Williams, Brian John Williams
  • Gamma secretase inhibitors
    Publication number: 20030114387
    Abstract: Gamma-secretase inhibitors, useful in the treatment or prevention of Alzheimer's disease, are disclosed. The preferred compounds have, as the central portion of the molecule, the structure (a) and are diastereoisomers of known protease inhibitors.
    Type: Application
    Filed: July 18, 2002
    Publication date: June 19, 2003
    Inventors: Jose Luis Castro Pineiro, Timothy Harrison, Peter Alan Hunt, Alan John Nadin
  • Gamma-secretase inhibitors
    Publication number: 20030100512
    Abstract: Compounds of formula (I) are disclosed which are diasteroisomers of a known class of protease inhibitors. The compounds inhibit &ggr;-secretase, and find use in the treatment and/or prevention of Alzheimer's disease.
    Type: Application
    Filed: October 7, 2002
    Publication date: May 29, 2003
    Inventors: Alan John Nadin, Graeme Irvine Stevenson
  • Substituted 1H-pyridinyl-2-ones as GABAA alpha 2/3 ligands
    Patent number: 6352994
    Abstract: Compounds according to Formula (I) or a salt thereof are selective ligands for GABAA receptors useful for treatment of disorders of the central nervous system:
    Type: Grant
    Filed: January 4, 2001
    Date of Patent: March 5, 2002
    Assignee: Merck Sharp & Dohme Limited
    Inventors: Ian James Collins, Stephen Robert Fletcher, Timothy Harrison, Paul David Leeson, Christopher Richard Moyes, Alan John Nadin, Michael Rowley, Timothy Jason Sparey, Martin Richard Teall
  • Investigational compounds
    Publication number: 20020013276
    Abstract: The present invention provides a compound of formula I or a salt thereof: 1
    Type: Application
    Filed: March 2, 2001
    Publication date: January 31, 2002
    Inventors: Alan John Nadin, Joseph George Neduvelil, Mohinder K. Sardana, Jules A. Shafer, Stephen J. Gardell, Ming-Tain Lai, Yueming Li, Bruce D. Dorsey, Dennis C. Dean
  • Substituted 1H-pyridinyl-2-ones as GABAA alpha 2/3 ligands
    Publication number: 20010018438
    Abstract: Compounds according to Formula (I) or a salt thereof are selective ligands for GABAA receptors useful for treatment of disorders of the central nervous system: 1
    Type: Application
    Filed: January 4, 2001
    Publication date: August 30, 2001
    Applicant: MERCK SHARP & DOHME LIMITED
    Inventors: Ian James Collins, Stephen Robert Fletcher, Timothy Harrison, Paul David Leeson, Christopher Richard Moyes, Alan John Nadin, Michael Rowley, Timothy Jason Sparey, Martin Richard Teall
  • Substituted 1H-pyridinyl-2-ones as GABAA-&agr; 2/3 ligands
    Patent number: 6200982
    Abstract: Substituted 1H-Pyridinyl-2-ones are useful as GABAA-Alpha 2/3 ligands.
    Type: Grant
    Filed: February 11, 2000
    Date of Patent: March 13, 2001
    Assignee: Merck & Dohme Limited
    Inventors: Ian James Collins, Stephen Robert Fletcher, Timothy Harrison, Paul David Leeson, Christopher Richard Moyes, Alan John Nadin, Michael Rowley, Timothy Jason Sparey, Martin Richard Teall