Abstract: A humidification system can include a heater base, a humidification chamber, and a breathing circuit. A cartridge can be removably coupled to the heater base. The cartridge can include various sensors, probes, sensor wire connectors, heater wire connectors, and/or other features. The cartridge can include features configured to mate with corresponding features on the humidification chamber and the heater base. The cartridge includes a memory, such as an EEPROM, or other suitable storage device. When the cartridge is installed on the heater base, the memory is electrically connected to a processor and/or memory of the heater base. Various models of cartridges can be produced for use with different humidification chambers, breathing circuits, and/or therapies. A connector can be configured to couple an inspiratory conduit to an outlet port of the humidification chamber. The connector can provide a pneumatic connection to the outlet port and an electrical connection to the cartridge.

Abstract: Methods of correcting vision for presbyopia, including remodeling a stroma with a laser to create an intracorneal shape, where the corneal shape includes a central region with a thickness that is about 50 microns or less measured from an extension of a shape of a peripheral region of the corneal shape, wherein remodeling a portion of the stroma increases a curvature of a central portion of the anterior surface of the cornea with a central elevation change for near vision.

Abstract: Methods of treating presbyopia of an eye. A corneal inlay is inserted within the cornea such that the central thickness of the corneal inlay is 3 to 7 times a central elevation change.

Abstract: Methods of correcting vision for presbyopia, including remodeling a stroma with a laser to create an intracorneal shape, where the corneal shape includes a central region with a thickness that is about 50 microns or less measured from an extension of a shape of a peripheral region of the corneal shape, wherein remodeling a portion of the stroma increases a curvature of a central portion of the anterior surface of the cornea with a central elevation change for near vision.

Abstract: Methods of correcting vision for presbyopia, including remodeling a stroma with a laser to create an intracorneal shape, where the corneal shape includes a central region with a thickness that is about 50 microns or less measured from an extension of a shape of a peripheral region of the corneal shape, wherein remodeling a portion of the stroma increases a curvature of a central portion of the anterior surface of the cornea with a central elevation change for near vision.

Abstract: Methods of lenticule extraction to correct for presbyopia that account for epithelial remodeling.

Abstract: Methods of designing corneal implants, such as inlays, to compensate for a corneal response, such as epithelial remodeling of the epithelial layer, to the presence of the implant. Additionally, methods of performing alternative corneal vision correction procedures to compensate for an epithelial response to the procedure. Methods of compensating for a corneal response when performing a vision correction procedure to create a center near region of the cornea for near vision while providing distance vision peripheral to the central near zone.

Abstract: Methods of designing corneal implants, such as inlays, to compensate for a corneal response, such as epithelial remodeling of the epithelial layer, to the presence of the implant. Additionally, methods of performing alternative corneal vision correction procedures to compensate for an epithelial response to the procedure. Methods of compensating for a corneal response when performing a vision correction procedure to create a center near region of the cornea for near vision while providing distance vision peripheral to the central near zone.

Abstract: Methods of determining a desired shape for the anterior surface of the cornea in vision correction procedures.

Abstract: Methods of designing corneal implants, such as inlays, to compensate for a corneal response, such as epithelial remodeling of the epithelial layer, to the presence of the implant. Additionally, methods of performing alternative corneal vision correction procedures to compensate for an epithelial response to the procedure. Methods of compensating for a corneal response when performing a vision correction procedure to create a center near region of the cornea for near vision while providing distance vision peripheral to the central near zone.

Abstract: The present invention relates to a peptide derivative represented by the general formula (I) or a salt thereof: Z-(CH2)n—CO—NH-Leu-Ile-Gly-AA1-AA2-CO—R (I) wherein Z represents an aryl group which may or may not have a substituent or a heteroaryl group which may or may not have a substituent; n represents 0, 1 or 2: AA1-AA2 represents Lys-Val or Arg-Leu; and R represents —OH or —NH2, and relates to a pharmaceutical composition comprising a peptide derivative represented by the general formula (I) or a salt thereof, and a pharmaceutically acceptable carrier thereof. The peptide derivative is useful as a prophylactic and therapeutic agent of dysfunction of masticatory, dysphagia, dysgeusia, ozostomia, intra-oral cavity dysphoria, intra-oral cavity infections, intra-oral cavity inflammations, dry eye, ectocornea detachment, keratitis, corneal ulcer, conjunctivitis, stomach ulcer, duodenal ulcer, gastritis, diarrhea, enteritis or Sjogren's syndrome.

Abstract: Provided herein are intracorneal inlays for correcting vision impairments by altering the shape of the anterior corneal surface. The physical design of the inlay to induce the desired change of the anterior corneal surface includes consideration of the biomechanical response of the corneal tissue to the physical shape of the inlay. This biomechanical response can differ depending on the thickness, diameter, and profile of the inlay. In one embodiment, inlays having diameters smaller than the pupil are provided for correcting presbyopia. To provide near vision, an inlay is implanted centrally in the cornea to induce an “effect” zone on the anterior corneal surface, within which diopter power is increased. Distance vision is provided by a region of the cornea peripheral to the “effect” zone. In another embodiment, small diameter inlays are provided that induce “effect” zones on the anterior corneal surface that are much larger in diameter than the inlays.

Abstract: Ophthalmic devices are provided having a violet-light vertical cut-off filter abruptly absorbs light between the wave lengths of between approximately and 400 nm and 450 nm such that a curve when plotted as percent transmission versus wavelength has the shape as depicted in FIG. 2. In one embodiment the ophthalmic devices are made from acrylates and the light absorbing compound is an Eastman Yellow 035 MA dye.

Abstract: Described herein are designs and design methods for intracorneal inlays with intrinsic dioper power (i.e., index of refraction different from the surrounding cornea tissue). The designs and design methods achieve a desired refractive change by a combination of the intrinsic diopter power of the inlay and the physical shape of the inlay, which alters the shape of the anterior cornea surface.

Abstract: Described herein are designs of intracorneal inlays to produce desired shapes of the cornea's anterior surface for correcting vision impairments. In an exemplarily embodiment, a thickness profile is defined by a difference between a desired post-operative anterior corneal surface that corrects a patient's vision impairment and the patient's pre-operative anterior corneal surface. An inlay is then dimensioned to substantially have the same thickness profile. When implanted in the patient's cornea, the thickness profile of the inlay is substantially transferred to the anterior corneal surface through the intervening corneal tissue, thereby producing the desired post-operative anterior corneal surface.

Abstract: A method and system for improving the efficiency of a database processing system for evaluating candidate data items representing search listings that are submitted for inclusion into a search engine database. Candidate search listings are automatically assessed for quality, style, and relevance to evaluate risk of unfavorable reception by a user and of potential exposure volume. Search listings which are higher-risk or higher-volume are routed through manual editorial review while lower-risk, lower-volume search listings are routed for immediate inclusion in the search database without manual editorial evaluation. Accordingly, human editorial efforts can be devoted to manual review of high-risk or high-volume search listings while efficiency is simultaneously improved in the processing system as a whole.

Abstract: A multi-zonal monofocal opthalmic lens comprises an inner zone, an intermediate zone, and an outer zone. The inner zone has a first optical power. The intermediate zone surrounds the inner zone and has a second optical power that is different from the first power by a magnitude that is less than at least about 0.75 Diopter. The outer zone surrounds the intermediate zone and has a third optical power different from the second optical power. In certain embodiments, the third optical power is equal to the first optical power.

Abstract: A mower including support for an operator in a standing position during use thereof. Specifically, the mower includes a support against which an operator may lean when operating the mower in the standing position. Additionally, the support includes a portion capable of being straddled and then sat upon by the operator. This capability allows the operator to relieve at least some of the pressure applied to his/her body during extended periods of standing on the platform.

Abstract: An ophthalmic lens for providing a plurality of foci has an optic comprising an anterior surface, a posterior surface, and an optical axis. The optic has a first region and a second region. The first region has a refractive optical power and comprises a multifocal phase plate for forming a first focus and a second focus. The second region has a refractive optical power and comprises a monofocal phase plate for forming a third focus. The multifocal phase plate and the monofocal phase plate may be disposed on first and second base curvatures, respectively, that may have different radii of curvature. The ophthalmic lens may also have an intermediate phase plate located between the multifocal phase plate and the monofocal phase plate, the intermediate phase plate comprising a third plurality of echelettes disposed on a third base curvature having a third radius of curvature.

Abstract: An ophthalmic lens for providing a plurality of foci has an optic comprising an anterior surface, a posterior surface, and an optical axis. The optic has a first region and a second region. The first region has a refractive optical power and comprises a multifocal phase plate for forming a first focus and a second focus. The second region has a refractive optical power and comprises a monofocal phase plate for forming a third focus. The multifocal phase plate and the monofocal phase plate may be disposed on first and second base curvatures, respectively, that may have different radii of curvature. The ophthalmic lens may also have an intermediate phase plate located between the multifocal phase plate and the monofocal phase plate, the intermediate phase plate comprising a third plurality of echelettes disposed on a third base curvature having a third radius of curvature.