Patents by Inventor Alan M. Ezrin

Alan M. Ezrin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Detection of microparticle-associated proteins associated with spontaneous preterm birth
    Patent number: 11835530
    Abstract: The present disclosure relates to biomarkers of preterm birth, biomarkers of term birth, and methods of use thereof. In particular, the present disclosure provides methods of determining whether a pregnant woman is at an increased risk for premature delivery. The present disclosure further provides methods for decreasing a pregnant woman's risk for premature delivery.
    Type: Grant
    Filed: January 20, 2021
    Date of Patent: December 5, 2023
    Assignee: NX Prenatal Inc.
    Inventors: Alan M. Ezrin, Brian D. Brohman
  • MICROVESICLE HISTONE H2AX AS A BIOMARKER FOR GENOTOXIC STRESS
    Publication number: 20230204593
    Abstract: The invention described herein relates to methods of monitoring genotoxic stress in a test subject, specifically by detecting the expression level of microvesicle-associated H2AX from a biological sample.
    Type: Application
    Filed: November 23, 2022
    Publication date: June 29, 2023
    Inventor: Alan M. EZRIN
  • USE OF TENASCIN-C AS AN EXTRACELLULAR MARKER OF TUMOR-DERIVED MICROPARTICLES
    Publication number: 20230160899
    Abstract: The present disclosure provides methods for isolating tumor-derived microparticles from a subject for analysis, specifically by isolating Tenascin-C positive microparticles from a sample from the subject to obtain tumor-derived microparticles. Methods for determining the expression status of biomarkers in the tumor-derived microparticles and methods for determining additional characteristics of the tumor-derived microparticles are also provided.
    Type: Application
    Filed: November 30, 2022
    Publication date: May 25, 2023
    Inventors: Alan M. EZRIN, Steven G. GRIFFITHS
  • Microvesicle histone H2AX as a biomarker for genotoxic stress
    Patent number: 11513125
    Abstract: The invention described herein relates to methods of monitoring genotoxic stress in a test subject, specifically by detecting the expression level of microvesicle-associated H2AX from a biological sample.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: November 29, 2022
    Assignee: PIOMA, INC.
    Inventor: Alan M. Ezrin
  • ELUTION OF MICROPARTICLES BY SIZE EXCLUSION CHROMATOGRAPHY USING WATER AS A MOBILE PHASE
    Publication number: 20220236277
    Abstract: The present disclosure relates to methods for eluting microparticles from a size exclusion chromatography column using water as a mobile phase. This method is useful for the detection of proteins associated with microparticles and provides an improved method to do so, as compared to using buffer as a mobile phase.
    Type: Application
    Filed: April 15, 2022
    Publication date: July 28, 2022
    Inventor: Alan M. EZRIN
  • 5-ALA for detection of brain tumors
    Patent number: 11307204
    Abstract: The present disclosure relates to methods for detecting brain tumors and assessing the recurrence of such tumors by administering a pharmaceutical composition comprising 5-aminolevulinic acid (5-ALA) and detecting the conversion of 5-ALA to protoporphyrin IX (PPIX) associated with brain-derived microparticles.
    Type: Grant
    Filed: June 7, 2019
    Date of Patent: April 19, 2022
    Assignee: PIOMA, INC.
    Inventor: Alan M. Ezrin
  • USE OF CIRCULATING MICROPARTICLES TO STRATIFY RISK OF SPONTANEOUS PRETERM BIRTH
    Publication number: 20210270840
    Abstract: The present disclosure relates to proteomic biomarkers of spontaneous preterm birth, proteomic biomarkers of term birth, and methods of use thereof. In particular, the present disclosure provides tools for determining whether a pregnant subject is at an increased risk for premature delivery, as well as tools for decreasing a pregnant subject's risk for premature delivery.
    Type: Application
    Filed: December 23, 2020
    Publication date: September 2, 2021
    Inventors: Brian D. BROHMAN, Zhen ZHANG, Kevin S. GOUDY, Robert C. DOSS, Alan M. EZRIN, Kevin Paul ROSENBLATT
  • TREATMENT OF SPONTANEOUS PRETERM BIRTH
    Publication number: 20210231674
    Abstract: The present disclosure relates to biomarkers of preterm birth, biomarkers of term birth, and methods of use thereof. In particular, the present disclosure provides methods of determining whether a pregnant woman is at an increased risk for premature delivery. The present disclosure further provides methods for decreasing a pregnant woman's risk for premature delivery.
    Type: Application
    Filed: January 20, 2021
    Publication date: July 29, 2021
    Inventors: Alan M. EZRIN, Brian D. BROHMAN
  • Treatment of spontaneous preterm birth
    Patent number: 10928402
    Abstract: The present disclosure relates to biomarkers of preterm birth, biomarkers of term birth, and methods of use thereof. In particular, the present disclosure provides methods of determining whether a pregnant woman is at an increased risk for premature delivery. The present disclosure further provides methods for decreasing a pregnant woman's risk for premature delivery.
    Type: Grant
    Filed: December 26, 2013
    Date of Patent: February 23, 2021
    Assignee: NX PRENATAL INC.
    Inventors: Alan M. Ezrin, Brian D. Brohman
  • Treatment of spontaneous preterm birth
    Patent number: 10877046
    Abstract: Provided herein are proteomic biomarkers of spontaneous preterm birth, proteomic biomarkers of term birth, and methods of use thereof. In particular, provided are tools for determining whether a pregnant subject is at an increased risk for premature delivery, as well as tools for decreasing a pregnant subject's risk for premature delivery.
    Type: Grant
    Filed: June 4, 2018
    Date of Patent: December 29, 2020
    Assignee: NX PRENATAL INC.
    Inventors: Brian D. Brohman, Zhen Zhang, Kevin S. Goudy, Robert C. Doss, Alan M. Ezrin, Kevin Paul Rosenblatt
  • 5-ALA FOR DETECTION OF BRAIN TUMORS
    Publication number: 20200124607
    Abstract: The present disclosure relates to methods for detecting brain tumors and assessing the recurrence of such tumors by administering a pharmaceutical composition comprising 5-aminolevulinic acid (5-ALA) and detecting the conversion of 5-ALA to protoporphyrin IX (PPIX) associated with brain-derived microparticles.
    Type: Application
    Filed: June 7, 2019
    Publication date: April 23, 2020
    Applicant: PIOMA, INC
    Inventor: Alan M. EZRIN
  • USE OF CIRCULATING MICROPARTICLES TO STRATIFY RISK OF SPONTANEOUS PRETERM BIRTH
    Publication number: 20190041391
    Abstract: The present disclosure relates to proteomic biomarkers of spontaneous preterm birth, proteomic biomarkers of term birth, and methods of use thereof. In particular, the present disclosure provides tools for determining whether a pregnant subject is at an increased risk for premature delivery, as well as tools for decreasing a pregnant subject's risk for premature delivery.
    Type: Application
    Filed: June 4, 2018
    Publication date: February 7, 2019
    Inventors: Brian D. BROHMAN, Zhen ZHANG, Kevin S. GOUDY, Robert C. DOSS, Alan M. EZRIN, Kevin Paul ROSENBLATT
  • 5-ALA FOR DETECTION OF BRAIN TUMORS
    Publication number: 20170192005
    Abstract: The present disclosure relates to methods for detecting brain tumors and assessing the recurrence of such tumors by administering a pharmaceutical composition comprising 5-aminolevulinic acid (5-ALA) and detecting the conversion of 5-ALA to protoporphyrin IX (PPIX) associated with brain-derived microparticles.
    Type: Application
    Filed: September 27, 2016
    Publication date: July 6, 2017
    Inventor: Alan M. EZRIN
  • 5-ALA for detection of brain tumors
    Patent number: 9493810
    Abstract: The present disclosure relates to methods for detecting brain tumors and assessing the recurrence of such tumors by administering a pharmaceutical composition comprising 5-aminolevulinic acid (5-ALA) and detecting the conversion of 5-ALA to protoporphyrin IX (PPIX) associated with brain-derived microparticles.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: November 15, 2016
    Assignee: PIOMA, INC.
    Inventor: Alan M. Ezrin
  • 5-ALA FOR DETECTION OF BRAIN TUMORS
    Publication number: 20160326566
    Abstract: The present disclosure relates to methods for detecting brain tumors and assessing the recurrence of such tumors by administering a pharmaceutical composition comprising 5-aminolevulinic acid (5-ALA) and detecting the conversion of 5-ALA to protoporphyrin IX (PPIX) associated with brain-derived microparticles.
    Type: Application
    Filed: March 15, 2013
    Publication date: November 10, 2016
    Applicant: Pioma Inc.
    Inventor: Alan M. EZRIN
  • USE OF TENASCIN-C AS AN EXTRACELLULAR MARKER OF TUMOR-DERIVED MICROPARTICLES
    Publication number: 20160097771
    Abstract: The present disclosure provides methods for isolating tumor-derived microparticles from a subject for analysis, specifically by isolating Tenascin-C positive microparticles from a sample from the subject to obtain tumor-derived microparticles. Methods for determining the expression status of biomarkers in the tumor-derived microparticles and methods for determining additional characteristics of the tumor-derived microparticles are also provided.
    Type: Application
    Filed: May 19, 2014
    Publication date: April 7, 2016
    Inventors: Alan M. EZRIN, Steven G. GRIFFITHS
  • MICROVESICLE HISTONE H2AX AS A BIOMARKER FOR GENOTOXIC STRESS
    Publication number: 20160041175
    Abstract: The invention described herein relates to methods of monitoring genotoxic stress in a test subject, specifically by detecting the expression level of microvesicle-associated H2AX from a biological sample.
    Type: Application
    Filed: March 14, 2014
    Publication date: February 11, 2016
    Inventor: Alan M. EZRIN
  • BIOMARKERS OF PRETERM BIRTH
    Publication number: 20150355188
    Abstract: The present disclosure relates to biomarkers of preterm birth, biomarkers of term birth, and methods of use thereof. In particular, the present disclosure provides methods of determining whether a pregnant woman is at an increased risk for premature delivery. The present disclosure further provides methods for decreasing a pregnant woman's risk for premature delivery.
    Type: Application
    Filed: December 26, 2013
    Publication date: December 10, 2015
    Inventors: Alan M. EZRIN, Brian D. BROHMAN
  • BIOMARKERS OF PRETERM BIRTH
    Publication number: 20140186332
    Abstract: The present disclosure relates to biomarkers of preterm birth, biomarkers of term birth, and methods of use thereof. In particular, the present disclosure provides methods of determining whether a pregnant woman is at an increased risk for premature delivery. The present disclosure further provides methods for decreasing a pregnant woman's risk for premature delivery.
    Type: Application
    Filed: March 12, 2013
    Publication date: July 3, 2014
    Applicant: NX Pharmagen
    Inventors: Alan M. EZRIN, Brian D. Brohman
  • 5-ALA FOR DETECTION OF BRAIN TUMORS
    Publication number: 20130330753
    Abstract: The present disclosure relates to methods for detecting brain tumors and assessing the recurrence of such tumors by administering a pharmaceutical composition comprising 5-aminolevulinic acid (5-ALA) and detecting the conversion of 5-ALA to protoporphyrin IX (PPIX) associated with brain-derived microparticles.
    Type: Application
    Filed: March 15, 2013
    Publication date: December 12, 2013
    Applicant: PIOMA INC.
    Inventor: Alan M. EZRIN