Abstract: A computer implemented method of evaluating interaction two or more medical products or conditions, in the context of a reference condition, based on a dataset of patient records includes developing a reference contingency lattice of lattice subsets from a subset of the patient records containing the reference condition, wherein the lattice subsets correspond to the number of patient records that contain each of the two or more medical products or conditions and combinations thereof. A plurality of comparison contingency lattices are developed, each of the comparison contingency lattices developed from a respective random subset of patient records not containing the reference condition, where each of the comparison contingency lattices include lattice subsets that correspond to the number of patient records that contain each of the two or more medical products or conditions and combinations thereof.

Abstract: A computer-implemented method of analyzing a dataset of pharmacovigilance data, includes determining a sample size-independent measure of association between two conditions of interest in the dataset of pharmacovigilance data; using a hypergeometric distribution to determine a measure of statistical unexpectedness between the conditions of interest in said dataset, wherein the distribution is based on an urn model under a hypothesis that the conditions are statistically independent; and displaying the measure of association with the measure of the statistical unexpectedness to identify a significant association between conditions of interest.

Abstract: A computer implemented method of evaluating interaction two or more medical products or conditions, in the context of a reference condition, based on a dataset of patient records includes developing a reference contingency lattice of lattice subsets from a subset of the patient records containing the reference condition, wherein the lattice subsets correspond to the number of patient records that contain each of the two or more medical products or conditions and combinations thereof. A plurality of comparison contingency lattices are developed, each of the comparison contingency lattices developed from a respective random subset of patient records not containing the reference condition, where each of the comparison contingency lattices include lattice subsets that correspond to the number of patient records that contain each of the two or more medical products or conditions and combinations thereof.

Abstract: A method is disclosed for determining the sequence of DNA bases by using two electrophoretic lanes for each DNA sample to be sequenced. Each lane incorporates two dyes.

Abstract: This invention uses the evanescent wave detection of particles to distinguish bound from free in an analyte-binding assay. Illumination below the critical angle is employed, and a beveled window is used to eliminate bulk fluorescence from the emitted evanescent wave liquid. The sample is held in a non-rigid film cuvette.

Abstract: This invention uses the evanescent wave detection of particles to distinguish bound from free in an analyte-binding assay. Illumination below the critical angle is employed, and a beveled window is used to eliminate bulk fluorescence from the emitted evanescent wave liquid. The sample is held in a non-rigid film cuvette.

Abstract: The method of this invention obtains the underlying peak shapes of two signal spectrums whose ratios are representative of different species. The underlying peak shapes are fitted to the signal spectrums in a way that yield accurate ratios. The ratios are accurate even when the location of the peaks are not precisely known.

Abstract: A sample of whole blood is stained with an acridine orange reagent, and is analyzed rapidly, a cell at a time, in a flow cytometry system having a sample stream dimension in the range of expected red cell dimensions. Red florescence and forward scatter data is utilized first to discriminate a cell from noise, and then to distinguish platelets from reticulocytes and red cells. The red cell and reticulocyte data is subjected to a correction such as rotational coordinate shift, and the shifted data are, by means of statistical procedures, utilized to determine threshold criteria separating red cells from reticulocytes, and to enumerate the cells on that basis.