Patents by Inventor Alan M. Smith

Alan M. Smith has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11410655
    Abstract: Provided is a voice assistance system with proactive routines that couples a remote server and respective user voice interactive devices to deliver a complete experience to the end user of the device. The voice assistance system can also provide a platform to connect remote users to customize commands (e.g., proactive or reactive) to improve day-to-day operation across groups of devices and/or users. For example, routines can be built for an organization and made available to voice interactive devices distributed by or on behalf of the organization. Administrators can select features for the device and pre-configure voice assistance devices with groups of pre-selected routines to deliver a device that is ready to go out of the box. Updates to a device or routines can be based on such groups. Additionally, primary routine instances can be linked to groups where changes to the primary instance are propagated to any linked users.
    Type: Grant
    Filed: July 26, 2021
    Date of Patent: August 9, 2022
    Assignee: LifePod Solutions, Inc.
    Inventors: Nirmalya K. De, Alan R. Bugos, Dale M. Smith, Stuart R. Patterson, Jonathan E. Gordon
  • Patent number: 11404062
    Abstract: Provided is a voice assistance system with proactive routines that couples a remote server and respective user voice interactive devices to deliver a complete experience to the end user of the device. The user devices can be managed by groups and/or associated entities who manage voice services for their users. For example, the entities can provide pre-configured voice routines that perform actions on behalf of their users. The voice assistance system can also allow users to customize these routines to improve day to day operation. In addition, external services and/or providers can be linked to the system and allowed to define routines that have external system dependencies. Avoiding and managing conflicts in this environment becomes quite challenging. Some approaches use execution queues and priority, others invoke time slices and limitations on assignment of routines to time slices to resolve these issues, among other examples.
    Type: Grant
    Filed: July 26, 2021
    Date of Patent: August 2, 2022
    Assignee: LifePod Solutions, Inc.
    Inventors: Nirmalya K. De, Alan R. Bugos, Dale M. Smith, Stuart R. Patterson, Jonathan E. Gordon
  • Publication number: 20210072230
    Abstract: The invention provides methods for predicting whether compounds are cardiotoxic by analyzing their effects on the ratios of concentrations of metabolites in cultured heart muscle cells.
    Type: Application
    Filed: March 8, 2019
    Publication date: March 11, 2021
    Inventors: Jessica A. Palmer, Alan M. Smith, Robert Burrier
  • Publication number: 20200348319
    Abstract: The invention provides methods of diagnosing autism spectrum disorders (ASD) by analyzing ratios of concentrations of selected amine containing compounds in a sample, such as a blood sample, from a subject. Based on the discovery that specific amine containing compounds and their ratios are dysregulated in patients with ASD, these metabotypes or subtypes of metabolism have the potential to diagnose earlier and suggest more precise treatment based on the metabolism of the individual. The invention provides methods of analyzing amine containing compounds and ratios in a test subject and determining whether the test subject has or is at risk of developing an ASD by comparing ratios from the test subject to ratios from subjects diagnosed with a neurodevelopmental disorder such as ASD who share a common profile of metabolism which is not found in the majority of typically developing subjects.
    Type: Application
    Filed: January 29, 2019
    Publication date: November 5, 2020
    Inventors: Alan M. Smith, Joseph King, Paul R. West, Michael Ludwig, Elizabeth L.R. Donley, Robert Burrier
  • Patent number: 10473641
    Abstract: The invention provides biomarker profiles of metabolites and methods for screening chemical compounds including pharmaceutical agents, lead and candidate drug compounds and other chemicals using human stem-like cells (hSLCs) or lineage-specific cells produced therefrom. The inventive methods are useful for testing toxicity, particularly developmental toxicity and detecting teratogenic effects of such chemical compounds. Specifically, a more predictive developmental toxicity model, based on an in vitro method that utilizes both hSLCs and metabolomics to discover biomarkers of developmental toxicity is disclosed.
    Type: Grant
    Filed: April 21, 2014
    Date of Patent: November 12, 2019
    Assignee: Stemina Biomarker Discovery, Inc.
    Inventors: Paul R. West, April M. Weir-Hauptman, Alan M. Smith, Elizabeth L. R. Donley, Gabriela G. Cezar
  • Patent number: 10330688
    Abstract: This invention provides methods and biomarkers for diagnosing autism by identifying cellular metabolites differentially produced in autistic patient samples versus non-autistic controls. Methods for identifying a unique profile of metabolites present or secreted in brain tissue, cerebrospinal fluid, plasma, or biofluids of autistic samples are described herein. The individual metabolites or a pattern of secreted metabolites provides metabolic signatures of autism, which can be used to provide a diagnosis thereof.
    Type: Grant
    Filed: December 7, 2016
    Date of Patent: June 25, 2019
    Assignees: Wisconsin Alumni Research Foundation, Stemina Biomarker Discovery, Inc.
    Inventors: Gabriela Gebrin Cezar, Alan M. Smith
  • Publication number: 20190128872
    Abstract: This present invention provides rapid, reproducible, biomarker-based screening methods for the developmental toxicity testing of compounds. The methods are designed to identify the exposure level at which a test compound perturbs metabolism in a manner predictive of developmental toxicity. In particular, the perturbation of two metabolites, ornithine and cystine, is measured, wherein a ratio of the fold change in ornithine to the fold change in cystine of less than or equal to about 0.88 is indicative of the teratogenicity of a test compound.
    Type: Application
    Filed: December 18, 2018
    Publication date: May 2, 2019
    Inventors: Alan M. Smith, Paul R. West, Jessica Palmer
  • Publication number: 20170192019
    Abstract: This invention provides methods and biomarkers for diagnosing autism by identifying cellular metabolites differentially produced in autistic patient samples versus non-autistic controls. Methods for identifying a unique profile of metabolites present of secreted in brain tissue, cerebrospinal fluid, plasma, or biofluids of autistic samples are described herein. The individual metabolites or a pattern of secreted metabolites provide metabolic signatures of autism, which can be used to provide a diagnosis thereof.
    Type: Application
    Filed: December 7, 2016
    Publication date: July 6, 2017
    Inventors: Gabriela Gebrin Cezar, Alan M. Smith
  • Patent number: 9547013
    Abstract: This invention provides methods and biomarkers for diagnosing autism by identifying cellular metabolites differentially produced in autistic patient samples versus non-autistic controls. Methods for identifying a unique profile of metabolites present of secreted in brain tissue, cerebrospinal fluid, plasma, or biofluids of autistic samples are described herein. The individual metabolites or a pattern of secreted metabolites provide metabolic signatures of autism, which can be used to provide a diagnosis thereof.
    Type: Grant
    Filed: April 29, 2011
    Date of Patent: January 17, 2017
    Assignees: Wisconsin Alumni Research Foundation, Stemina Biomarker Discovery, Inc.
    Inventors: Gabriela Gebrin Cezar, Alan M. Smith
  • Publication number: 20150148970
    Abstract: A motor controller coupled to a motor is described. The motor controller includes a wireless communication device and a computing device coupled to the wireless communication device. The computing device is configured to communicatively couple with a client computing device using the wireless communication device, wirelessly receive at least one setting from the client computing device, and operate the motor pursuant to the at least one setting, to move liquid in an aquatic environment.
    Type: Application
    Filed: November 25, 2013
    Publication date: May 28, 2015
    Applicant: Regal Beloit America, Inc.
    Inventors: Yilcan Guzelgunler, Jason Jon Kreidler, William Edward Young, Marc C. McKinzie, Mitchell T. Kiser, Alan M. Smith
  • Publication number: 20140273069
    Abstract: The invention provides biomarker profiles of metabolites and methods for screening chemical compounds including pharmaceutical agents, lead and candidate drug compounds and other chemicals using human stem-like cells (hSLCs) or lineage-specific cells produced therefrom. The inventive methods are useful for testing toxicity, particularly developmental toxicity and detecting teratogenic effects of such chemical compounds. Specifically, a more predictive developmental toxicity model, based on an in vitro method that utilizes both hSLCs and metabolomics to discover biomarkers of developmental toxicity is disclosed.
    Type: Application
    Filed: April 21, 2014
    Publication date: September 18, 2014
    Applicant: STEMINA BIOMARKER DISCOVERY, INC.
    Inventors: Paul R. West, April M. Weir-Hauptman, Alan M. Smith, Elizabeth L.R. Donley, Gabriela G. Cezar
  • Patent number: 8703424
    Abstract: The invention provides biomarker profiles of metabolites and methods for screening chemical compounds including pharmaceutical agents, lead and candidate drug compounds and other chemicals using human stem-like cells (hSLCs) or lineage-specific cells produced therefrom. The inventive methods are useful for testing toxicity, particularly developmental toxicity and detecting teratogenic effects of such chemical compounds. Specifically, a more predictive developmental toxicity model, based on an in vitro method that utilizes both hSLCs and metabolomics to discover biomarkers of developmental toxicity is disclosed.
    Type: Grant
    Filed: March 22, 2011
    Date of Patent: April 22, 2014
    Assignee: Stemina Biomarker Discovery, Inc.
    Inventors: Paul R. West, April M. Weir-Hauptman, Alan M. Smith, Elizabeth L. R. Donley, Gabriela G. Cezar
  • Publication number: 20120190055
    Abstract: This invention provides methods and biomarkers for diagnosing autism by identifying cellular metabolites differentially produced in autistic patient samples versus non-autistic controls. Methods for identifying a unique profile of metabolites present of secreted in brain tissue, cerebrospinal fluid, plasma, or biofluids of autistic samples are described herein. The individual metabolites or a pattern of secreted metabolites provide metabolic signatures of autism, which can be used to provide a diagnosis thereof.
    Type: Application
    Filed: April 29, 2011
    Publication date: July 26, 2012
    Applicants: STEMINA BIOMARKER DISCOVERY, INC., WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Gabriela Gebrin Cezar, Alan M. Smith
  • Publication number: 20110312019
    Abstract: The invention provides biomarker profiles of metabolites and methods for screening chemical compounds including pharmaceutical agents, lead and candidate drug compounds and other chemicals using human stem-like cells (hSLCs) or lineage-specific cells produced therefrom. The inventive methods are useful for testing toxicity, particularly developmental toxicity and detecting teratogenic effects of such chemical compounds. Specifically, a more predictive developmental toxicity model, based on an in vitro method that utilizes both hSLCs and metabolomics to discover biomarkers of developmental toxicity is disclosed.
    Type: Application
    Filed: March 22, 2011
    Publication date: December 22, 2011
    Applicant: Stemina Biomarker Discovery, Inc.
    Inventors: Paul R. WEST, April M. WEIR-HAUPTMAN, Alan M. SMITH, Elizabeth L.R. DONLEY, Gabriela G. CEZAR
  • Patent number: 7876543
    Abstract: A gas discharge lamp power supply having a base, a pair of opposed side walls extending from the base, and opposed first and second end walls extending from the base between the opposed side walls. The first end wall has a sloped wall extending angularly between the side walls, and two input terminals are mounted on the sloped wall. In another embodiment, the power supply has a control with a nonvolatile memory for storing an error code in response to a detected fault condition, thereby permitting the error code to be displayed upon power being removed from and then, subsequently reapplied.
    Type: Grant
    Filed: October 20, 2006
    Date of Patent: January 25, 2011
    Assignee: FRANCE/ A Scott Fetzer Company
    Inventors: William T. Hopkins, Anthony W. Banks, Alan M. Smith, Louis B. Pickvet, Robert L. Towe, Charles A. Schlemm
  • Publication number: 20080187952
    Abstract: The invention provides methods for measuring cellular response to ionization radiation (IR). The invention also provides a plurality of diagnostic and prognostic cancer biomarkers for assessing cellular response to IR.
    Type: Application
    Filed: January 31, 2008
    Publication date: August 7, 2008
    Applicant: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Gabriela G. Cezar, Alan M. Smith
  • Patent number: 7283351
    Abstract: A gas discharge lamp power supply having a base, a pair of opposed side walls extending from the base, and opposed first and second end walls extending from the base between the opposed side walls. The first end wall has a sloped wall extending angularly between the side walls, and two input terminals are mounted on the sloped wall. In another embodiment, the power supply has a control with a nonvolatile memory for storing an error code in response to a detected fault condition, thereby permitting the error code to be displayed upon power being removed from and then, subsequently reapplied.
    Type: Grant
    Filed: March 28, 2005
    Date of Patent: October 16, 2007
    Assignee: France/A Scott Fetzer Company
    Inventors: William T. Hopkins, Anthony W. Banks, Alan M. Smith, Louis B. Pickvet, Robert L. Towe, Charles A. Schlemm
  • Patent number: 6925317
    Abstract: An alignment device and related systems and methods for aligning at least one apparatus with respect to a surface of a tissue. The alignment device comprises a tissue interface member suitable for positioning on the surface of the tissue and mating with the apparatus to maintain alignment of the apparatus during an operation of the apparatus. The alignment device is useful to align various apparatus that are part of a continuous analyte monitoring system.
    Type: Grant
    Filed: June 12, 2000
    Date of Patent: August 2, 2005
    Assignee: SpectRx, Inc.
    Inventors: Mark A. Samuels, Krishna S. Kumar, Garrett T. Robinson, J. David Farquhar, Allison Minton, Diedre Williams, Michael R. Hatch, Alan M. Smith, Teresa Woods, Mark Vreeke
  • Patent number: 6485326
    Abstract: An enclosure for an electrical connection between two high-voltage cables that includes an electrically nonconductive separator integral with a mounting base for receiving the high-voltage cables. An electrically nonconductive tubular cover extends over the electrical connection and the high-voltage cables and is releasably attached to the base. The separator has at least two resiliently mounted fingers, and the electrically nonconductive cover extends over the fingers to depress and move the fingers into contact with the high-voltage cables, thereby securing the high-voltage cables in the mounting base. The high-voltage cables are extended beyond the mounting base a distance equal to a desired spacing separating the electrical connection between the high-voltage cables and an electrical conductor associated with the mounting base. The tubular cover is transparent so that the electrical connection joining the high-voltage cables can be visually inspected through the cover.
    Type: Grant
    Filed: October 19, 2000
    Date of Patent: November 26, 2002
    Assignee: France/Scott Fetzer Company
    Inventors: Terry J. Trainor, Alan M. Smith, Mary J. Springer
  • Patent number: 5847909
    Abstract: A transformer control circuit which includes a ground fault detection circuit that detects ground fault currents in the transformer secondary and delivers a ground fault detection signal to the primary circuit. This circuit derives power from the secondary winding and transmits the ground fault detection signal through an optical isolation barrier, thus avoiding the use of an auxiliary transformer. The ground fault detection circuit further includes safety features for detecting whether AC power is being supplied without earth ground being connected, and/or whether there is an undesired electrical connection between a transformer output connection and earth ground, which would defeat the ground fault detection circuit.
    Type: Grant
    Filed: April 17, 1997
    Date of Patent: December 8, 1998
    Assignee: France/Scott Fetzer Company
    Inventors: William Thomas Hopkins, Alan M. Smith