Abstract: A small, portable, hand-sized apparatus for detecting microorganisms or chemicals in liquid samples by fluorescence polarization. The apparatus operates using a low power excitation light source, such as an LED, in order to irradiate a sample with polarized light. Detection of emitted polarized light from the sample is detected in multiple planes simultaneously using low power detectors resulting in an elimination of error caused by drifts in intensity in sequential measurements and in reducing assay time.

Abstract: The inventive subject matter relates to a method for detecting the presence of a biological substance of interest in a test sample of saliva or oral fluid, comprising combining said test sample with a fluorescence-labeled ligand to said biological substance and detecting a change in the fluorescence polarization of said test sample produced by binding of said fluorescence-labeled ligand to said biological substance. In one aspect of the inventive subject matter, said method comprises additional steps for comparing the fluorescence polarization of said test sample with the fluorescence polarization of a control solution. Also provided is a miniaturized, portable apparatus for measuring the fluorescence polarization of a liquid sample.

Abstract: The present invention relates to methods of treating a BRCA associated disorder, particularly a BRCA1 associated cancer. The invention also provides a method of diagnosis or prognosis of the disorder, preferably a BRCA-1 associated cancer and methods of determining suitable treatment regimes for the disorder or cancer. The invention also provides a transgenic animal useful as a model for testing potential therapeutics for the disorder or cancer.

Abstract: A pipe and tube cleaning system, particularly useful for cleaning scale from pipes and tubes used in oil and gas production operations and containing naturally occurring radioactive materials in the scale, includes an elongated closable tub for supporting a section of pipe or tube for combined hydraulic jet blast and mechanical cutting and cleaning action by a lance insertable within the pipe to remove scale from the interior of the pipe. A slurry of particulate material removed from the pipe and the cleaning liquid (water) is collected in the tub and discharged to a particle size reduction and filtering system which reduces the particle size of the material to form a slurry of very fine particles which may be disposed of through an injection well. Some of the slurry may be returned to the system for use as cleaning liquid. Pipe is loaded into and removed from the tub by a pipe handling mechanism including retractable supports with ramp surfaces which position the pipe for movement into and out of the tub.