Patents by Inventor ALAN MELCHER

ALAN MELCHER has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTI-CANCER VACCINES AND RELATED THERAPY
    Publication number: 20230173048
    Abstract: The present invention provides an anti-cancer vaccine comprising: (i) at least one peptide comprising the amino acid sequence of a neoantigen encoded by a mutant homologous recombination (HR) DNA repair gene selected from the group: BRCA1, BRCA2, PALB2, CDK12, RAD51B, RAD51C and RAD51D, wherein the mutant gene comprises a reversion mutation; and/or (ii) at least one polynucleotide encoding the at least one peptide of (i). Also provided are engineered T cells that recognise said neoantigen. Related methods and medical uses of the vaccine and/or engineered T cell are provided, including for the treatment of cancers, such as homologous recombination (HR) deficient cancers that acquire PARP inhibitor resistance or platinum resistance by development of reversion mutations in an HR DNA repair gene selected from the group: BRCA1, BRCA2, PALB2, CDK12, RAD51B, RAD51C and RAD51D.
    Type: Application
    Filed: April 28, 2021
    Publication date: June 8, 2023
    Applicant: The Institute of Cancer Research: Royal Cancer Hospital
    Inventors: Stephen Pettitt, Christopher Lord, Marco Punta, Alan Melcher
  • Methods and materials for treating cancer
    Patent number: 10022431
    Abstract: This document provides methods and materials related to treating cancer. For example, methods and materials for using nucleic acid libraries to treat cancer are provided.
    Type: Grant
    Filed: February 10, 2011
    Date of Patent: July 17, 2018
    Assignees: Mayo Foundation for Medical Education and Research, Leeds University
    Inventors: Richard G. Vile, Timothy J. Kottke, Jose S. Pulido, Alan Melcher, Peter Selby
  • METHODS AND MATERIALS FOR TREATING CANCER
    Publication number: 20120308601
    Abstract: This document provides methods and materials related to treating cancer. For example, methods and materials for using nucleic acid libraries to treat cancer are provided.
    Type: Application
    Filed: February 10, 2011
    Publication date: December 6, 2012
    Applicants: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
    Inventors: Richard G. Vile, Timothy J. Kottke, Jose S. Pulido, Alan Melcher, Peter Selby
  • INDUCING IMMUNE-MEDIATED TUMOR CELL DEATH
    Publication number: 20100292309
    Abstract: This document provides methods and materials related to treating cancer. For example, methods and materials that include using CD40L polypeptide, an hsp70 polypeptide, and a cytotoxic polypeptide to trigger an immune response directed against cancer cells are provided.
    Type: Application
    Filed: March 7, 2008
    Publication date: November 18, 2010
    Inventors: Richard G. Vile, Timothy J. Kottke, Jose S. Pulido, Jill M. Thompson, Alan Melcher
  • DONOR CELLS EXPRESSING FUSOGENS
    Publication number: 20020042127
    Abstract: Disclosed is a cell which expresses a surface marker associated with a professional antigen presenting cell, and a fusogenic membrane protein, where the cell may also express at its surface a tumor cell marker. Also disclosed is a fusion hybrid formed by the fusion of a tumor cell and a professional antigen presenting cell (APC) such that the resulting fusion hybrid expresses an APC marker, a tumor cell marker, and a fusogenic membrane glycoprotein. Also disclosed are compositions comprising the cells and fusion hybrids, and methods of making and using the hybrids.
    Type: Application
    Filed: November 22, 1999
    Publication date: April 11, 2002
    Inventors: STEPHEN JAMES RUSSELL, RICHARD VILE, ANDREW BATEMAN, ALAN MELCHER