Patents by Inventor Alan Negus

Alan Negus has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Resolution Process For Preparing (+)-2S,3S)-2-(3-Chlorophenyl)-3,3,3-Trimethyl-2-Morpholinol
    Publication number: 20080281096
    Abstract: Disclosed is a method for preparing (+)-(2S,3S)-2-(3-chlorophenyl)-3,5,5-trimethyl-2-morpholinol and pharmaceutically acceptable salts such as the (+)-(2S,3S)-2-(3-chlorophenyl)-3,5,5-trimethyl-2-morpholinol hydrochloride salt via dynamic kinetic resolution.
    Type: Application
    Filed: October 25, 2004
    Publication date: November 13, 2008
    Inventors: Michael Anthony Harris, Alan Negus
  • Pharmaceutically active morpholinol
    Publication number: 20050096318
    Abstract: Disclosed is the compound (+)-(2S,3S)-2-(3-chlorophenyl)-3,5,5-trimethyl-2-morpholinol and pharmaceutically acceptable salts and solvates thereof, methods for preparing them, pharmaceutical compositions comprising them, and processes for their preparation; also disclosed is a method of treating depression, attention deficit hyperactivity disorder (ADHD), obesity, migraine, sexual dysfunction, Parkinson's disease, Alzheimer's disease, or addiction to cocaine or nicotine-containing (especially tobacco) products using such compound, salts, solvates or compositions.
    Type: Application
    Filed: September 21, 2004
    Publication date: May 5, 2005
    Inventors: Toby Broom, Monica Delpogetto, Richard Atkins, Alan Negus, Paul Oxley
  • Pharmaceutically active morpholinol
    Patent number: 6855820
    Abstract: Disclosed is the compound (+)-(2S,3S)-2-(3-chlorophenyl)-3,5,5-trimethyl-2-morpholinol and pharmaceutically acceptable salts and solvates thereof, methods for preparing them, pharmaceutical compositions comprising them, and processes for their preparation; also disclosed is a method of treating depression, attention deficit hyperactivity disorder (ADHD), obesity, migraine, sexual dysfunction, Parkinson's disease, Alzheimer's disease, or addiction to cocaine or nicotine-containing (especially tobacco) products using such compound, salts, solvates or compositions.
    Type: Grant
    Filed: May 17, 2002
    Date of Patent: February 15, 2005
    Assignee: SmithKline Beecham Corporation
    Inventors: Toby Broom, Monica Delpogetto, Richard Atkins, Alan Negus, Paul William Oxley
  • Pharmaceutically active morpholinol
    Publication number: 20030027827
    Abstract: Disclosed is the compound (+)-(2S,3S)-2-(3-chlorophenyl)-3,5,5-trimethyl-2-morpholinol and pharmaceutically acceptable salts and solvates thereof, methods for preparing them, pharmaceutical compositions comprising them, and processes for their preparation; also disclosed is a method of treating depression, attention deficit hyperactivity disorder (ADHD), obesity, migraine, sexual dysfunction, Parkinson's disease, Alzheimer's disease, or addiction to cocaine or nicotine-containing (especially tobacco) products using such compound, salts, solvates or compositions.
    Type: Application
    Filed: May 17, 2002
    Publication date: February 6, 2003
    Inventors: Toby Broom, Monica Delpogetto, Richard Atkins, Alan Negus, Paul William Oxley
  • Process for the preparation of diphosphonate derivatives
    Patent number: 6048995
    Abstract: A process for the preparation of a compound of formula I, ##STR1## wherein R.sup.1 and R.sup.2 are independently C.sub.1-6 alkyl, R.sup.3 is hydroxy and R.sup.4 and R.sup.5 are independently C.sub.1-6 alkyl is disclosed. The process comprises reacting a compound of formula II, ##STR2## wherein R.sup.1, R.sup.2 and R.sup.3 are defined as in formula I and X is a leaving group, with a compound of formula III, ##STR3## wherein R.sup.4 and R.sup.5 are independently C.sub.1-6 alkyl, in the presence of a base.
    Type: Grant
    Filed: August 20, 1998
    Date of Patent: April 11, 2000
    Inventors: Trevor John Grinter, John David Hayler, Alan Negus, Michael Anthony Harris