Patents by Inventor Alan P. Wolffe

Alan P. Wolffe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modulation of stem cells using zinc finger proteins
    Patent number: 10888589
    Abstract: Methods and compositions for modifying stem cells using one or more ZFPs are disclosed. Such methods and compositions are useful for facilitating processes such as, for example, dedifferentiating cells, differentiating stem cells into the desired phenotype, propagating stem cells and/or facilitating cloning.
    Type: Grant
    Filed: April 13, 2017
    Date of Patent: January 12, 2021
    Assignee: Sangamo Therapeutics, Inc.
    Inventors: Alan P. Wolffe, Michael Moore, Timothy Farries, Trevor Collingwood, Fyodor Urnov
  • MODULATION OF STEM CELLS USING ZINC FINGER PROTEINS
    Publication number: 20170224741
    Abstract: Methods and compositions for modifying stem cells using one or more ZFPs are disclosed. Such methods and compositions are useful for facilitating processes such as, for example, dedifferentiating cells, differentiating stem cells into the desired phenotype, propagating stem cells and/or facilitating cloning.
    Type: Application
    Filed: April 13, 2017
    Publication date: August 10, 2017
    Inventors: Alan P. Wolffe, Michael Moore, Timothy Farries, Trevor Collingwood, Fyodor Urnov
  • Modulation of stem cells using zinc finger proteins
    Patent number: 9624509
    Abstract: Methods and compositions for modifying stem cells using one or more ZFPs are disclosed. Such methods and compositions are useful for facilitating processes such as, for example, dedifferentiating cells, differentiating stem cells into the desired phenotype, propagating stem cells and/or facilitating cloning.
    Type: Grant
    Filed: May 5, 2014
    Date of Patent: April 18, 2017
    Assignee: SANGAMO BIOSCIENCES, INC.
    Inventors: Alan P. Wolffe, Michael Moore, Timothy Farries, Trevor Collingwood, Fyodor Urnov
  • MODULATION OF STEM CELLS USING ZINC FINGER PROTEINS
    Publication number: 20140234970
    Abstract: Methods and compositions for modifying stem cells using one or more ZFPs are disclosed. Such methods and compositions are useful for facilitating processes such as, for example, dedifferentiating cells, differentiating stem cells into the desired phenotype, propagating stem cells and/or facilitating cloning.
    Type: Application
    Filed: May 5, 2014
    Publication date: August 21, 2014
    Applicant: Sangamo BioSciences, Inc.
    Inventors: Alan P. Wolffe, Michael Moore, Timothy Farries, Trevor Collingwood, Fyodor Urnov
  • Targeted modification of chromatin structure
    Patent number: 8071370
    Abstract: Methods and compositions for targeted modification of chromatin structure, within a region of interest in cellular chromatin, are provided. Such methods and compositions are useful for facilitating processes such as, for example, transcription and recombination, that require access of exogenous molecules to chromosomal DNA sequences.
    Type: Grant
    Filed: July 9, 2010
    Date of Patent: December 6, 2011
    Assignee: Sangamo Biosciences, Inc.
    Inventors: Alan P. Wolffe, Elizabeth J. Wolffe, legal representative, Trevor Collingwood, Philip D. Gregory, Andrew Snowden, Fyodor Urnov
  • Libraries of regulatory sequences, methods of making and using same
    Patent number: 7923542
    Abstract: Methods and compositions for the identification, isolation and characterization of regulatory DNA sequences in a cell of interest are provided. In particular, libraries of regulatory sequences are provided, in which each member of the library comprises a polynucleotide comprising sequences from an accessible region of cellular chromatin.
    Type: Grant
    Filed: October 24, 2001
    Date of Patent: April 12, 2011
    Assignee: Sangamo Biosciences, Inc.
    Inventors: Alan P. Wolffe, Elizabeth J. Wolffe, legal representative, Fyodor Urnov
  • Targeted modification of chromatin structure
    Publication number: 20100323424
    Abstract: Methods and compositions for targeted modification of chromatin structure, within a region of interest in cellular chromatin, are provided. Such methods and compositions are useful for facilitating processes such as, for example, transcription and recombination, that require access of exogenous molecules to chromosomal DNA sequences.
    Type: Application
    Filed: July 9, 2010
    Publication date: December 23, 2010
    Inventors: Alan P. Wolffe, Elizabeth J. Wolffe, Trevor Collingwood, Philip D. Gregory, Andrew Snowden, Fyodor Urnov
  • Targeted modification of chromatin structure
    Patent number: 7785792
    Abstract: Methods and compositions for targeted modification of chromatin structure, within a region of interest in cellular chromatin, are provided. Such methods and compositions are useful for facilitating processes such as, for example, transcription and recombination, that require access of exogenous molecules to chromosomal DNA sequences.
    Type: Grant
    Filed: July 10, 2008
    Date of Patent: August 31, 2010
    Assignee: Sangamo Biosciences, Inc.
    Inventors: Alan P. Wolffe, Elizabeth J. Wolffe, legal representative, Trevor Collingwood, Philip D. Gregory, Andrew Snowden, Fyodor Urnov
  • Modulation of gene expression using insulator binding proteins
    Publication number: 20090181455
    Abstract: Methods and compositions for regulating gene expression are provided. In particular, methods and compositions including insulator domains for targeted regulation of a gene or transgene are provided.
    Type: Application
    Filed: October 9, 2008
    Publication date: July 16, 2009
    Inventors: Alan P. Wolffe, Elizabeth J. Wolffe
  • Targeted modification of chromatin structure
    Publication number: 20090023153
    Abstract: Methods and compositions for targeted modification of chromatin structure, within a region of interest in cellular chromatin, are provided. Such methods and compositions are useful for facilitating processes such as, for example, transcription and recombination, that require access of exogenous molecules to chromosomal DNA sequences.
    Type: Application
    Filed: July 10, 2008
    Publication date: January 22, 2009
    Inventors: Alan P. Wolffe, Trevor Collingwood
  • Nuclear reprogramming using IWSI and related chromatin remodeling ATPases
    Patent number: 7053264
    Abstract: Methods and compositions for dedifferentiating nuclei from somatic cells are provided. Such methods and compositions are useful for facilitating processes such as, for example, cloning and immortalization of cells.
    Type: Grant
    Filed: September 28, 2001
    Date of Patent: May 30, 2006
    Assignee: Sangamo Biosciences, Inc.
    Inventors: Elizabeth Wolffe, legal representative, Alan P. Wolffe, deceased
  • Targeted modification of chromatin structure
    Patent number: 7001768
    Abstract: Methods and compositions for targeted modification of chromatin structure, within a region of interest in cellular chromatin, are provided. Such methods and compositions are useful for facilitating processes such as, for example, transcription and recombination, that require access of exogenous molecules to chromosomal DNA sequences.
    Type: Grant
    Filed: April 27, 2001
    Date of Patent: February 21, 2006
    Assignee: Sangamo Biosciences, Inc.
    Inventor: Alan P. Wolffe
  • Modulation of gene expression using localization domains
    Patent number: 6919204
    Abstract: Methods and compositions for regulating gene expression are provided. In particular, methods and compositions comprising localization domains, and fusions of localization domains with DNA binding domains and, optionally regulatory domains, are provided.
    Type: Grant
    Filed: September 28, 2001
    Date of Patent: July 19, 2005
    Assignee: Sangamo Biosciences, Inc.
    Inventors: Elizabeth J. Wolffe, Fyodor Urnov, Albert Lai, Eva Raschke, Alan P. Wolffe
  • Human heparanase gene regulatory sequences
    Publication number: 20040132033
    Abstract: Nucleotide sequences comprising regulatory regions of the human heparanase gene are provided. Also provided are methods and compositions for regulating heparanase expression, as well as methods and compositions for using heparanase sequences to regulate a heterologous target gene.
    Type: Application
    Filed: October 23, 2003
    Publication date: July 8, 2004
    Inventors: Elizabeth J. Wolffe, Alan P. Wolffe, Hong Qi
  • Modulation of gene expression using insulator binding proteins
    Publication number: 20030232781
    Abstract: Methods and compositions for regulating gene expression are provided. In particular, methods and compositions including insulator domains for targeted regulation of a gene or transgene are provided.
    Type: Application
    Filed: May 27, 2003
    Publication date: December 18, 2003
    Inventors: Alan P. Wolffe, Elizabeth J. Wolffe
  • Methods of using randomized libraries of zinc finger proteins for the identification of gene function
    Publication number: 20030134318
    Abstract: The present invention relates to methods of using libraries of randomized zinc finger proteins to identify genes associated with selected phenotypes.
    Type: Application
    Filed: January 6, 2003
    Publication date: July 17, 2003
    Applicant: Sangamo BioSciences, Inc.
    Inventors: Casey C. Case, Qiang Liu, Edward J. Rebar, Alan P. Wolffe
  • Databases of regulatory sequences; methods of making and using same
    Publication number: 20030129603
    Abstract: Methods and compositions for the identification, isolation and characterization of regulatory DNA sequences in a cell of interest are provided. Also provided are libraries of regulatory sequences obtained according to the methods, and databases comprising collections of regulatory sequences for a particular cell of interest. In addition, various uses for the regulatory sequences so obtained, and uses for the databases of regulatory sequences, are provided. Also disclosed are computer systems and computer program products for utilizing the databases to conduct various genetic analyses, and uses of accessible regulatory sequences in the design of vectors bearing transgenes.
    Type: Application
    Filed: October 24, 2001
    Publication date: July 10, 2003
    Inventors: Alan P. Wolffe, Fyodor Urnov, Dmitry Guschin, Trevor Collingwood, Xiao-Yong Li, Brian Johnstone, Elizabeth J. Wolffe
  • Modulation of gene expression using localization domains
    Publication number: 20030082552
    Abstract: Methods and compositions for regulating gene expression are provided. In particular, methods and compositions comprising localization domains, and fusions of localization domains with DNA binding domains and, optionally regulatory domains, are provided.
    Type: Application
    Filed: September 28, 2001
    Publication date: May 1, 2003
    Inventors: Alan P. Wolffe, Fyodor Urnov, Albert Lai, Eva Raschke, Elizabeth J. Wolffe
  • Targeted modification of chromatin structure
    Publication number: 20030049649
    Abstract: Methods and compositions for targeted modification of chromatin structure, within a region of interest in cellular chromatin, are provided. Such methods and compositions are useful for facilitating processes such as, for example, transcription and recombination, that require access of exogenous molecules to chromosomal DNA sequences.
    Type: Application
    Filed: February 24, 2002
    Publication date: March 13, 2003
    Inventors: Alan P. Wolffe, Elizabeth J. Wolffe, Trevor Collingwood, Andrew Snowden
  • Methods of using randomized libraries of zinc finger proteins for the identification of gene function
    Patent number: 6503717
    Abstract: The present invention relates to methods of using libraries of randomized zinc finger proteins to identify genes associated with selected phenotypes.
    Type: Grant
    Filed: December 6, 2000
    Date of Patent: January 7, 2003
    Assignee: Sangamo Biosciences, Inc.
    Inventors: Casey C. Case, Qiang Liu, Edward J. Rebar, Alan P. Wolffe