Abstract: The invention concerns a modified oncolytic adenovirus of serotype Ad5; a pharmaceutical composition comprising same; and a method of treating cancer using same wherein said modified adenovirus comprises at least one point mutation(s) in the hexon hypervariable region 7 (HVR7 mutation) to prevent virus binding with coagulation factor 10 (FX); at least one point mutation(s) in the fiber knob region AB loop (KO1 mutation) to prevent virus binding with the coxsackie and adenovirus receptor (CAR); and at least one point mutation(s) in the penton integrin binding motif Arg-Gly-Asp (RGD) to prevent virus binding with ?v?3/?v?5 integrin.

Abstract: The invention concerns a modified low seroprevalence adenovirus: a pharmaceutical composition comprising same; and a method of treating cancer using same.

Abstract: The computer-implemented method (100) to provide alternative flavor compositions, comprises: a step (105) of inputting, upon a computer interface, at least one flavor ingredient digital identifier, the resulting input corresponding to a composition of flavor ingredients, each ingredient digital identifier being associated with at least one equivalent constitutive molecule, each equivalent constitutive molecule being associated with at least one property, a step (110) of transposing, by a computing system, the input composition into a list of at least one equivalent constitutive molecule as a function of at least one input ingredient digital identifier, a step (115) of defining, upon a computer interface, at least one reformulation rule to be applied to the at least one transposed equivalent constitutive molecule and/or to at least one alternative flavor ingredient obtained during a step of determining, the step (120) of determining, by a computing system, a selection of at least one alternative flavor ingr

Abstract: A travel blocking apparatus for blocking the movement of a car movably disposed in a hoistway. The travel blocking apparatus includes a flapper mechanism attached to the car and configured, when deployed, to extend an arm outside of an outer side periphery of the car and a prop device disposed in the hoistway and configured to contact the arm when said arm is extended so as to stop the car from moving downwardly in the hoistway.

Abstract: Described herein is a food grade emulsion capable of modulating sensory properties in foods and beverages. The emulsion is characterized by the presence in its dispersed phase of at least one enzymatically modified lipid component. The emulsion constitutes a stable and effective flavour delivery system and can thus be incorporated as such in a food composition or a beverage composition.

Abstract: Depth cameras may be placed within an elevator car hoistway to capture depth images of the elevator rope. 3D sensing software may be used to identify the rope within the depth images and assign tracking points to locations along the rope. Tracked images are saved over time and compared to prior tracked images to determine the movement of tracked points between images. Movement of tracked points may be used to determine the velocity, acceleration, frequency of wave motion, and other characteristics of the rope during a period of time. When measured characteristics exceed specified thresholds, the system may take one or more actions to mitigate the undesirable behavior or provide notification of the undesirable behavior.

Abstract: The invention concerns a modified oncolytic adenovirus of serotype Ad5; a pharmaceutical composition comprising same; and a method of treating cancer using same wherein said modified adenovirus comprises at least one point mutation(s) in the hexon hypervariable region 7 (HVR7 mutation) to prevent virus binding with coagulation factor 10 (FX); at least one point mutation(s) in the fiber knob region AB loop (KO1 mutation) to prevent virus binding with the coxsackie and adenovirus receptor (CAR); and at least one point mutation(s) in the penton integrin binding motif Arg-Gly-Asp (RGD) to prevent virus binding with ?V?3/?V?5 integrin.

Abstract: A fluid sensor has a core defining a fluid flow path and a cavity member located externally of the core. The cavity member includes an electrically-conductive composite material including a matrix and one or more reinforcing elements embedded within the matrix. The cavity member is configured so as to provide confinement for an electromagnetic field and the core is configured so as to permit transmission therethrough of electromagnetic radiation at a frequency of the electromagnetic field. The electromagnetic field may be a radiofrequency (RF) electromagnetic field. The fluid sensor can be used in the measurement of the composition and/or flow characteristics of fluid in the fluid flow path.

Abstract: A travel blocking apparatus for blocking the movement of a car movably disposed in a hoistway. The travel blocking apparatus includes a flapper mechanism attached to the car and configured, when deployed, to extend an arm outside of an outer side periphery of the car and a prop device disposed in the hoistway and configured to contact the arm when said arm is extended so as to stop the car from moving downwardly in the hoistway.

Abstract: A fluid sensor has a core defining a fluid flow path and a cavity member located externally of the core. The cavity member includes an electrically-conductive composite material including a matrix and one or more reinforcing elements embedded within the matrix. The cavity member is configured so as to provide confinement for an electromagnetic field and the core is configured so as to permit transmission therethrough of electromagnetic radiation at a frequency of the electromagnetic field. The electromagnetic field may be a radiofrequency (RF) electromagnetic field. The fluid sensor can be used in the measurement of the composition and/or flow characteristics of fluid in the fluid flow path.

Abstract: A method for use in measuring a composition of a multiphase fluid which includes flowing a multiphase fluid through a fluid flow path defined by a wall of a fluid conduit is disclosed. The wall includes an electrically non-conductive material. The method includes establishing an electromagnetic field which extends through the electrically non-conductive material of the wall of the fluid conduit into the fluid and measuring a property of the electromagnetic field over a measurement time period. The method also includes transmitting additional energy through the fluid over the measurement time period independently of the electromagnetic field and measuring the additional energy transmitted through the fluid over the measurement time period. The method may be used to unambiguously determine a composition of a multiphase fluid which has different components.

Abstract: An apparatus for measuring a composition of a fluid has a fluid conduit with a wall defining a fluid flow path, a transmitting antenna, a receiving antenna, and an electrically conductive waveguide member for electromagnetic coupling with the transmitting antenna and the receiving antenna and for guiding an electromagnetic field from the transmitting antenna to the receiving antenna along a waveguide path. The waveguide member is separated from the fluid flow path by an electrically insulating inner region of the wall. The waveguide member defines an opening disposed towards the fluid flow path to permit a portion of the electromagnetic field to extend through the opening and the inner region of the wall into the fluid flow path.

Abstract: A fluid sensor includes a core defining a fluid flow path, a confinement member located externally of the core, and a patch antenna located between the fluid flow path and the confinement member. The confinement member is configured to confine an electromagnetic field which extends into the fluid flow path. The patch antenna is configured to couple an electrical signal to and/or from the electromagnetic field. The fluid sensor may be configured for measuring the composition and/or flow rate of a fluid and, in particular but not exclusively, for measuring the composition and/or flow rate of mixtures of oil, water and gas.

Abstract: A fluid sensor (10) comprises a core (27) defining a fluid flow path (21) and a cavity member (30) located externally of the core. The cavity member (30) comprises an electrically-conductive composite material including a matrix and one or more reinforcing elements embedded within the matrix. The cavity member (30) is configured so as to provide confinement for an electromagnetic field and the core (27) is configured so as to permit transmission therethrough of electromagnetic radiation at a frequency of the electromagnetic field. The electromagnetic field may be a radiofrequency (RF) electromagnetic field. The fluid sensor (10) may be used in the measurement of the composition and/or flow characteristics of fluid in the fluid flow path (21).

Abstract: A method for use in measuring a composition of a multiphase fluid which includes flowing a multiphase fluid through a fluid flow path defined by a wall of a fluid conduit is disclosed. The wall includes an electrically non-conductive material. The method includes establishing an electromagnetic field which extends through the electrically non-conductive material of the wall of the fluid conduit into the fluid and measuring a property of the electromagnetic field over a measurement time period. The method also includes transmitting additional energy through the fluid over the measurement time period independently of the electromagnetic field and measuring the additional energy transmitted through the fluid over the measurement time period. The method may be used to unambiguously determine a composition of a multiphase fluid which has different components.

Abstract: Depth cameras may be placed within an elevator car hoistway to capture depth images of the elevator rope. 3D sensing software may be used to identify the rope within the depth images and assign tracking points to locations along the rope. Tracked images are saved over time and compared to prior tracked images to determine the movement of tracked points between images. Movement of tracked points may be used to determine the velocity, acceleration, frequency of wave motion, and other characteristics of the rope during a period of time. When measured characteristics exceed specified thresholds, the system may take one or more actions to mitigate the undesirable behavior or provide notification of the undesirable behavior.

Abstract: An apparatus for measuring a composition of a fluid has a fluid conduit with a wall defining a fluid flow path, a transmitting antenna, a receiving antenna, and an electrically conductive waveguide member for electromagnetic coupling with the transmitting antenna and the receiving antenna and for guiding an electromagnetic field from the transmitting antenna to the receiving antenna along a waveguide path. The waveguide member is separated from the fluid flow path by an electrically insulating inner region of the wall. The waveguide member defines an opening disposed towards the fluid flow path to permit a portion of the electromagnetic field to extend through the opening and the inner region of the wall into the fluid flow path.

Abstract: The invention relates to the field of gene transfer, and in particular to the use of adenoviral vectors of serotype Ad49 for gene delivery to vascular tissue.

Abstract: A fluid sensor includes a core defining a fluid flow path, a confinement member located externally of the core, and a patch antenna located between the fluid flow path and the confinement member. The confinement member is configured to confine an electromagnetic field which extends into the fluid flow path. The patch antenna is configured to couple an electrical signal to and/or from the electromagnetic field. The fluid sensor may be configured for measuring the composition and/or flow rate of a fluid and, in particular but not exclusively, for measuring the composition and/or flow rate of mixtures of oil, water and gas.

Abstract: A fluid sensor (10) comprises a core (27) defining a fluid flow path (21) and a cavity member (30) located externally of the core. The cavity member (30) comprises an electrically-conductive composite material including a matrix and one or more reinforcing elements embedded within the matrix. The cavity member (30) is configured so as to provide confinement for an electromagnetic field and the core (27) is configured so as to permit transmission therethrough of electromagnetic radiation at a frequency of the electromagnetic field. The electromagnetic field may be a radiofrequency (RF) electromagnetic field. The fluid sensor (10) may be used in the measurement of the composition and/or flow characteristics of fluid in the fluid flow path (21).