Patents by Inventor Alan Pestronk

Alan Pestronk has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTIBODIES TO DISULFATED HEPARIN DISACCHARIDE IN THE DIAGNOSIS OF NEUROPATHY
    Publication number: 20220404375
    Abstract: Methods aiding in the diagnosis of certain neuropathies are disclosed, in which the titer of antibodies to a disulfated heparin disaccharide is assessed in a test sample from a subject. Also disclosed are apparatus and kits that can be used in the methods of the invention.
    Type: Application
    Filed: June 27, 2022
    Publication date: December 22, 2022
    Inventor: Alan Pestronk
  • ANTIBODIES TO DISULFATED HEPARIN DISACCHARIDE IN THE DIAGNOSIS OF NEUROPATHY
    Publication number: 20200371116
    Abstract: Methods aiding in the diagnosis of certain neuropathies are disclosed, in which the titer of antibodies to a disulfated heparin disaccharide is assessed in a test sample from a subject. Also disclosed are apparatus and kits that can be used in the methods of the invention.
    Type: Application
    Filed: June 8, 2020
    Publication date: November 26, 2020
    Inventor: Alan Pestronk
  • Sequences associated with TDP-43 proteinopathies and methods of using the same
    Patent number: 10683544
    Abstract: The present invention provides nucleic acids and peptides, and methods of using the nucleic acids and peptides to identify subjects at risk for a TDP-43 proteinopathy. The invention also provides for an array comprising the nucleic acids and peptides of the invention.
    Type: Grant
    Filed: November 8, 2016
    Date of Patent: June 16, 2020
    Assignee: Washington University
    Inventors: Nigel J. Cairns, Robert H. Baloh, Alan Pestronk, Michael A. Gitcho, Alison M. Goate
  • ANTIBODIES TO DISULFATED HEPARIN DISACCHARIDE IN THE DIAGNOSIS OF NEUROPATHY
    Publication number: 20180292417
    Abstract: Methods aiding in the diagnosis of certain neuropathies are disclosed, in which the titer of antibodies to a disulfated heparin disaccharide is assessed in a test sample from a subject. Also disclosed are apparatus and kits that can be used in the methods of the invention.
    Type: Application
    Filed: June 8, 2018
    Publication date: October 11, 2018
    Inventor: Alan Pestronk
  • ANTIBODIES TO DISULFATED HEPARIN DISACCHARIDE IN THE DIAGNOSIS OF NEUROPATHY
    Publication number: 20170108515
    Abstract: Methods aiding in the diagnosis of certain neuropathies are disclosed, in which the titer of antibodies to a disulfated heparin disaccharide is assessed in a test sample from a subject. Also disclosed are apparatus and kits that can be used in the methods of the invention.
    Type: Application
    Filed: December 27, 2016
    Publication date: April 20, 2017
    Inventor: Alan Pestronk
  • SEQUENCES ASSOCIATED WITH TDP-43 PROTEINOPATHIES AND METHODS OF USING THE SAME
    Publication number: 20170067112
    Abstract: The present invention provides nucleic acids and peptides, and methods of using the nucleic acids and peptides to identify subjects at risk for a TDP-43 proteinopathy. The invention also provides for an array comprising the nucleic acids and peptides of the invention.
    Type: Application
    Filed: November 8, 2016
    Publication date: March 9, 2017
    Inventors: Nigel J. Cairns, Robert H. Baloh, Alan Pestronk, Michael A. Gitcho, Alison M. Goate
  • Antibodies to disulfated heparin disaccharide in the diagnosis of neuropathy
    Patent number: 9535072
    Abstract: Methods aiding in the diagnosis of certain neuropathies are disclosed, in which the titer of antibodies to a disulfated heparin disaccharide is assessed in a test sample from an subject. Also disclosed are apparatus and kits that can be used in the methods of the invention.
    Type: Grant
    Filed: September 2, 2010
    Date of Patent: January 3, 2017
    Assignee: WASHINGTON UNIVERSITY
    Inventor: Alan Pestronk
  • Sequences associated with TDP-43 proteinopathies and methods of using the same
    Patent number: 9523128
    Abstract: The present invention provides nucleic acids and peptides, and methods of using the nucleic acids and peptides to identify subjects at risk for a TDP-43 proteinopathy. The invention also provides for an array comprising the nucleic acids and peptides of the invention.
    Type: Grant
    Filed: October 14, 2014
    Date of Patent: December 20, 2016
    Assignee: WASHINGTON UNIVERSITY
    Inventors: Nigel J. Cairns, Robert H. Baloh, Alan Pestronk, Michael A. Gitcho, Alison M. Goate
  • SEQUENCES ASSOCIATED WITH TDP-43 PROTEINOPATHIES AND METHODS OF USING THE SAME
    Publication number: 20150065384
    Abstract: The present invention provides nucleic acids and peptides, and methods of using the nucleic acids and peptides to identify subjects at risk for a TDP-43 proteinopathy. The invention also provides for an array comprising the nucleic acids and peptides of the invention.
    Type: Application
    Filed: October 14, 2014
    Publication date: March 5, 2015
    Inventors: Nigel J. Cairns, Robert H. Baloh, Alan Pestronk, Michael A. Gitcho, Alison M. Goate
  • Sequences associated with TDP-43 proteinopathies and methods of using the same
    Patent number: 8889597
    Abstract: The present invention provides nucleic acids and peptides, and methods of using the nucleic acids and peptides to identify subjects at risk for a TDP-43 proteinopathy. The invention also provides for an army comprising the nucleic acids and peptides of the invention.
    Type: Grant
    Filed: January 30, 2009
    Date of Patent: November 18, 2014
    Assignee: Washington University
    Inventors: Nigel J. Cairns, Robert H Baloh, Alan Pestronk, Michael A. Gitcho, Alison M. Goate
  • ANTIBODIES TO DISULFATED HEPARIN DISACCHARIDE IN THE DIAGNOSIS OF NEUROPATHY
    Publication number: 20120183978
    Abstract: Methods aiding in the diagnosis of certain neuropathies are disclosed, in which the titer of antibodies to a disulfated heparin disaccharide is assessed in a test sample from an subject. Also disclosed are apparatus and kits that can be used in the methods of the invention.
    Type: Application
    Filed: September 2, 2010
    Publication date: July 19, 2012
    Applicant: THE WASHINGTON UNIVERSITY
    Inventor: Alan Pestronk
  • SEQUENCES ASSOCIATED WITH TDP-43 PROTEINOPATHIES AND METHODS OF USING THE SAME
    Publication number: 20110065600
    Abstract: Nucleic acids and peptides and methods of using thereof to identify subjects at risk for a TDP-43 proteinopathy are disclosed An array is also disclosed which contains the nucleic acids and peptides
    Type: Application
    Filed: January 30, 2009
    Publication date: March 17, 2011
    Applicant: THE WASHINGTON UNIVERSITY
    Inventors: Niegel J. Cairns, Robert H Baloh, Alan Pestronk, Michael A. Gitcho, Alison M. Goate
  • Antibodies to trisulfated heparin disaccharide in painful sensory axonal neuropathy
    Patent number: 7175989
    Abstract: Methods aiding in the diagnosis of certain painful, predominantly sensory, polyneuropathies are disclosed, in which the amount of antibodies to trisulfated disaccharide is assessed in a test sample. Also disclosed are kits that can be used in the methods of the invention.
    Type: Grant
    Filed: August 20, 2002
    Date of Patent: February 13, 2007
    Inventor: Alan Pestronk
  • Antibodies to trisulfated heparin disaccharide in painful sensory axonal neuropathy
    Publication number: 20040038311
    Abstract: Methods aiding in the diagnosis of certain painful, predominantly sensory, polyneuropathies are disclosed, in which the amount of antibodies to trisulfated disaccharide is assessed in a test sample. Also disclosed are kits that can be used in the methods of the invention.
    Type: Application
    Filed: August 20, 2002
    Publication date: February 26, 2004
    Inventor: Alan Pestronk
  • Antibodies to heparan sulfate glycosaminoglycans in the diagnosis of polyneuropathies
    Patent number: 6228598
    Abstract: Methods aiding in the diagnosis of certain immune-mediated, motor-sensory polyneuropathies, both chronic and acute, by assessing the amount of antibodies to heparan sulfate glycosaminoglycan, either acetylated or non-acetylated, in a test sample, are disclosed, as are kits that can be used in the methods.
    Type: Grant
    Filed: October 2, 1998
    Date of Patent: May 8, 2001
    Assignee: Washington University
    Inventor: Alan Pestronk
  • Autoantibodies and their targets in the diagnosis of peripheral neuropathies
    Patent number: 6121004
    Abstract: The present invention relates to methods of diagnosing peripheral neuropathies that comprise determining the titer of autoantibodies directed toward particular nervous system antigens. It also provides for substantially purified preparations of specific antigens, namely neuroprotein-1, histone H3 (NP-2), .beta.-tubulin (NP-3), neuroprotein-4, neuroprotein-5, NP-9 antigen, and SP neural antigen, which may be used in such diagnostic methods.
    Type: Grant
    Filed: January 16, 1997
    Date of Patent: September 19, 2000
    Assignee: Washington University
    Inventor: Alan Pestronk
  • Diagnosis of motor neuropathy by detection of antibodies
    Patent number: 6077681
    Abstract: Methods of detecting antibody to GM1 ganglioside in a sample, comprising covalent linkage of GM1 ganglioside to a solid-phase reactant, are disclosed. The methods of detecting antibody to GM1 ganglioside can be used in methods of diagnosing motor neuropathies, such as multifocal motor neuropathy or immune-mediated motor neuropathy, in an individual. The amount of antibody specific to GM1 ganglioside in a test sample from a individual is measured; a titer of antibody to GM1 ganglioside that is greater than 1,800 is indicative of disease.
    Type: Grant
    Filed: June 30, 1997
    Date of Patent: June 20, 2000
    Assignee: Washington University
    Inventor: Alan Pestronk
  • Autoantibodies and their targets in the diagnosis of peripheral neuropathies
    Patent number: 6020140
    Abstract: The present invention relates to methods of diagnosing peripheral neuropathies that comprise determining the titer of autoantibodies directed toward particular nervous system antigens. It also provides for substantially purified preparations of specific antigens, namely neuroprotein-1, histone H3 (NP-2), .beta.-tubulin (NP-3), neuroprotein-4, neuroprotein-5, NP-9 antigen, and SP neural antigen, which may be used in such diagnostic methods.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: February 1, 2000
    Assignee: Washington University
    Inventor: Alan Pestronk
  • Autoantibodies and their targets in the diagnosis of peripheral neuropathies
    Patent number: 5989829
    Abstract: The present invention relates to methods of diagnosing peripheral neuropathies by determining the titer of autoantibodies directed toward particular nervous system antigens. It also provides for substantially purified preparations of specific antigens, namely neuroprotein-1, histone H3 (neuroprotein-2), .beta.-tubulin (neuroprotein-3), neuroprotein-4, neuroprotein-5, and NP-9 antigen which can be used in such diagnostic methods.
    Type: Grant
    Filed: January 29, 1997
    Date of Patent: November 23, 1999
    Assignee: Washington University
    Inventor: Alan Pestronk
  • Autoantibodies and their targets in the diagnosis of peripheral neuropathies
    Patent number: 5985578
    Abstract: The present invention relates to methods of diagnosing peripheral neuropathies which comprises the steps of determining the titer of autoantibodies directed toward particular nervous system antigens. It also provides for substantially purified preparations of specific antigens, namely neuroprotein-1, histone H3 (neuroprotein-2), .beta.-tubulin (neuroprotein-3), neuroprotein-4, neuroprotein-5, and NP-9 antigen which may be used in such diagnostic methods.
    Type: Grant
    Filed: October 18, 1993
    Date of Patent: November 16, 1999
    Assignee: Washington University
    Inventor: Alan Pestronk