Patents by Inventor Alan Peter Lewis

Alan Peter Lewis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NOGO-A Neutralizing Immunoglobulins for the Treatment of Neurological Diseases
    Publication number: 20140147435
    Abstract: The present invention relates to antibodies to NOGO, pharmaceutical formulations containing them and to the use of such antibodies in the treatment and/or prophylaxis of neurological diseases/disorders.
    Type: Application
    Filed: May 7, 2013
    Publication date: May 29, 2014
    Inventors: Jonathan Henry ELLIS, Paul Andrew Hamblin, Alan Peter Lewis, Paul Alexander Wilson
  • BCMA (CD269/TNFRSF17) - BINDING PROTEINS
    Publication number: 20140105915
    Abstract: The present invention concerns antigen binding proteins and fragments thereof which specifically bind B Cell Maturation Antigen (BCMA), particularly human BCMA (hBCMA) and which inhibit the binding of BAFF and APRIL to the BCMA receptor. Further disclosed are pharmaceutical compositions, screening and medical treatment methods.
    Type: Application
    Filed: May 24, 2012
    Publication date: April 17, 2014
    Applicant: Glaxo Group Limited
    Inventors: Paul Algate, Stephanie Jane Clegg, Jennifer L. Craigen, Paul Andrew Hamblin, Alan Peter Lewis, Patrick Mayes, Radha Shah Parmar, Trevor Anthony Kenneth Wattam
  • IL-13 binding protein
    Patent number: 8680245
    Abstract: The present invention relates to antigen binding proteins to human IL-13, including anti-IL-13 antibodies and anti-IL-3/anti-IL-4 mAbdAbs, pharmaceutical formulations containing them and to the use of such antigen binding proteins in the treatment and/or prophylaxis of inflammatory diseases such as asthma or IPF.
    Type: Grant
    Filed: May 26, 2010
    Date of Patent: March 25, 2014
    Assignee: Glaxo Group Limited
    Inventors: Claire Ashman, Jonathan Henry Ellis, Paul Andrew Hamblin, Alan Peter Lewis, Martin Anibal Orecchia
  • NOVEL ANTIGEN BINDING PROTEINS
    Publication number: 20130310281
    Abstract: The present invention provides novel antigen-binding proteins derived from human germline VH domains, having improved expression and improved biophysical characteristics.
    Type: Application
    Filed: January 27, 2012
    Publication date: November 21, 2013
    Applicant: Glaxo Group Limited
    Inventors: Emma R. Harding, Ekaterini Kotsopoulou, Alan Peter Lewis, Susannah Thornhill, Mark Uden
  • HUMANISED ANTIGEN BINDING PROTEINS TO MYOSTATIN6
    Publication number: 20130142788
    Abstract: The present invention relates to humanised antigen binding proteins, such as antibodies, which bind to myostatin, polynucleotides encoding such antigen binding proteins, pharmaceutical compositions comprising said antigen binding proteins and methods of manufacture. The present invention also concerns the use of such humanised antigen binding proteins in the treatment or prophylaxis of diseases associated with any one or a combination of decreased muscle mass, muscle strength and muscle function.
    Type: Application
    Filed: June 2, 2011
    Publication date: June 6, 2013
    Inventors: Claire Ashman, Stephen Ashman, Paul Andrew Hamblin, Alan Peter Lewis, Martin Anibal Orecchia
  • NOVEL USES
    Publication number: 20120315267
    Abstract: The present invention relates to antibodies which multiple antigen specificities and their use in treating human diseases
    Type: Application
    Filed: February 9, 2011
    Publication date: December 13, 2012
    Applicant: GLAXOSMITHKLINE LLC
    Inventors: Stephanie Jane Clegg, Eric Dobrzynski, Jonathan Henry Ellis, Volker Germaschewski, Alexis Paul Godillot, Zdenka Ludmila Jonak, Alan Peter Lewis, John Richard White
  • ANTIGEN BINDING PROTEINS
    Publication number: 20120225055
    Abstract: The present invention relates to antigen binding proteins, such as antibodies, which bind to serum amyloid P component (SAP), polynucleotides encoding such antigen binding proteins, pharmaceutical compositions comprising said antigen binding proteins and methods of manufacture. The present invention also concerns the use of such antigen binding proteins in the treatment or prophylaxis of diseases associated with amyloid deposition including systemic amyloidosis, local amyloidosis, Alzheimer's disease, and type 2 diabetes.
    Type: Application
    Filed: March 1, 2011
    Publication date: September 6, 2012
    Inventors: Tejinder Kaur BHINDER, Susannah Karen Ford, Volker Germaschewski, Alan Peter Lewis, Mark Brian Pepys
  • ANTI-IL-23 IMMUNOGLOBULINS
    Publication number: 20120128689
    Abstract: The present invention relates to antigen binding proteins to human IL-23, pharmaceutical formulations containing them and to the use of such antigen binding proteins in the treatment and/or prophylaxis of inflammatory diseases such as Rheumatoid Arthritis (RA).
    Type: Application
    Filed: March 30, 2010
    Publication date: May 24, 2012
    Applicant: Glaxo Group Limited
    Inventors: Jane Elizabeth Clarkson, Ruth McAdam, Alan Peter Lewis
  • IL-13 BINDING PROTEIN
    Publication number: 20120082682
    Abstract: The present invention relates to antigen binding proteins to human IL-13, including anti-IL-13 antibodies and anti-IL-3/anti-IL-4 mAbdAbs, pharmaceutical formulations containing them and to the use of such antigen binding proteins in the treatment and/or prophylaxis of inflammatory diseases such as asthma or IPF.
    Type: Application
    Filed: May 26, 2010
    Publication date: April 5, 2012
    Inventors: Claire Ashman, Jonathan Henry Ellis, Paul Andrew Hamblin, Alan Peter Lewis, Martin Anibal Orecchia
  • ANTIGEN-BINDING PROTEINS
    Publication number: 20120070439
    Abstract: The invention relates to linkers suitable for use in antigen-binding proteins, certain antigen binding proteins and methods of making such proteins and uses thereof.
    Type: Application
    Filed: May 26, 2010
    Publication date: March 22, 2012
    Inventors: Paul Andrew Hamblin, Alan Peter Lewis, Martin Anibal Orecchia, Radha Shah Parmar
  • IL-23 ANTIBODIES
    Publication number: 20110206686
    Abstract: The present invention relates to antigen binding proteins to human IL-23, pharmaceutical formulations containing them and to the use of such antigen binding proteins in the treatment and/or prophylaxis of inflammatory diseases such as Rheumatoid Arthritis (RA).
    Type: Application
    Filed: October 3, 2008
    Publication date: August 25, 2011
    Inventors: Gary Peter Bembridge, Jane Elizabeth Clarkson, Jonathan Henry Ellis, Paul Andrew Hamblin, George Kopsidas, Alan Peter Lewis, Ruth Mcadam
  • NOGO-A Neutralizing Immunoglobulins for the Treatment of Neurological Diseases
    Publication number: 20110054149
    Abstract: The present invention relates to antibodies to NOGO, pharmaceutical formulations containing them and to the use of such antibodies in the treatment and/or prophylaxis of neurological diseases/disorders.
    Type: Application
    Filed: August 23, 2010
    Publication date: March 3, 2011
    Inventors: JONATHAN HENRY ELLIS, PAUL ANDREW HAMBLIN, ALAN PETER LEWIS, PAUL ALEXANDER WILSON
  • ANTIGEN BINDING PROTEINS
    Publication number: 20110014182
    Abstract: Antigen binding proteins that bind ?-amyloid peptide, in particular human ?-amyloid peptide; methods of treating diseases or disorders characterised by elevated ?-amyloid levels or ?-amyloid deposits, particularly Alzheimer's disease and diseases or disorders affecting the eye or optic nerve characterised by elevated ?-amyloid levels or ?-amyloid deposits, including age related macular degeneration and glaucoma type diseases and ?-amyloid dependent cataract formation, with said antigen binding proteins; pharmaceutical compositions comprising said antigen binding proteins; and methods of manufacture.
    Type: Application
    Filed: December 9, 2008
    Publication date: January 20, 2011
    Inventors: Philippe Marc Louis Alard, Ian Richard Catchpole, Jonathan Henry Ellis, Susannah Karen Ford, Gerald Wayne Gough, Volker Germaschewski, Alan Peter Lewis, Peter Ernest Soden, Pamela Joan Thomas, Trevor Anthony Kenneth Wattam
  • IMMUNOGLOBULINS
    Publication number: 20100303821
    Abstract: The present invention relates to antigen binding proteins to human IL-13, including anti-IL-13 antibodies and anti-IL-3/anti-IL-4 mAbdAbs, pharmaceutical formulations containing them and to the use of such antigen binding proteins in the treatment and/or prophylaxis of inflammatory diseases such as asthma or IPF.
    Type: Application
    Filed: May 26, 2010
    Publication date: December 2, 2010
    Applicant: GLAXO GROUP LIMITED
    Inventors: CLAIRE ASHMAN, JONATHAN HENRY ELLIS, PAUL ANDREW HAMBLIN, ALAN PETER LEWIS, MARTIN ANIBAL ORECCHIA
  • Immunoglobulins which bind NOGO
    Patent number: 7780964
    Abstract: The present invention relates to antibodies to NOGO, pharmaceutical formulations containing them and to the use of such antibodies in the treatment and/or prophylaxis of neurological diseases/disorders.
    Type: Grant
    Filed: July 6, 2005
    Date of Patent: August 24, 2010
    Assignee: Glaxo Group Limited
    Inventors: Jonathan Henry Ellis, Paul Andrew Hamblin, Alan Peter Lewis, Paul Alexander Wilson
  • NOVEL ANTIBODIES AGAINST IGF-IR
    Publication number: 20100047243
    Abstract: The present invention relates to antibodies or antigen binding fragments thereof which specifically binds to IGF-1R, specifically hIGF-1R. Also disclosed are antibody preparations comprising antibodies or antigen binding fragments of the invention. Methods of producing such antibodies or antigen binding fragments and uses thereof are also included within the scope of the present invention.
    Type: Application
    Filed: February 12, 2008
    Publication date: February 25, 2010
    Inventors: Michael Neil Burden, Jonathan Henry Ellis, Paul Andrew Hamblin, Alan Peter Lewis, Radba Shah
  • ANTIGEN BINDING PROTEINS
    Publication number: 20090162358
    Abstract: Antigen binding proteins that bind ?-amyloid peptide, in particular human ?-amyloid peptide; methods of treating diseases or disorders characterised by elevated ?-amyloid levels or ?-amyloid deposits, particularly Alzheimer's disease and diseases or disorders affecting the eye or optic nerve characterised by elevated ?-amyloid levels or ?-amyloid deposits, including age related macular degeneration and glaucoma type diseases and ?-amyloid dependent cataract formation, with said antigen binding proteins; pharmaceutical compositions comprising said antigen binding proteins; and methods of manufacture.
    Type: Application
    Filed: December 9, 2008
    Publication date: June 25, 2009
    Inventors: Philippe Marc Louis Alard, Jonathan Henry Ellis, Susannah Karen Ford, Volker Germaschewski, Alan Peter Lewis, Peter Ernest Soden, Pamela Joan Thomas, Trevor Anthony Kenneth Wattam
  • IMMUNOGLOBULINS
    Publication number: 20090123479
    Abstract: The present invention relates to antigen binding proteins to human IL-23, pharmaceutical formulations containing them and to the use of such antigen binding proteins in the treatment and/or prophylaxis of inflammatory diseases such as Rheumatoid Arthritis (RA).
    Type: Application
    Filed: October 3, 2008
    Publication date: May 14, 2009
    Inventors: Gary Peter Bembridge, Jane Elizabeth Clarkson, Jonathan Henry Ellis, Paul Andrew Hamblin, George Kopsidas, Alan Peter Lewis, Ruth McAdam
  • Vaccine
    Publication number: 20030194391
    Abstract: The present invention relates to an isolated polypeptide useful for immunisation against self-antigens. In particular the invention relates to a self-protein that is capable of raising auto-antibodies when administered in vivo. The invention particularly relates to rendering human cytokines immunogenic in humans. The invention further relates to pharmaceutical compositions comprising such compounds and their use in medicine and to methods for their production.
    Type: Application
    Filed: September 3, 2002
    Publication date: October 16, 2003
    Inventors: Claire Ashman, James Scott Crowe, Jonathan Henry Ellis, Alan Peter Lewis
  • Novel protein
    Publication number: 20030165818
    Abstract: The present invention provides a method for identification of a substance that modulates serine protease activity, which method comprises:
    Type: Application
    Filed: January 23, 2002
    Publication date: September 4, 2003
    Inventors: Mark Robert Edbrooke, Alan Peter Lewis