Abstract: The present disclosure describes boron containing pyrimidine compounds, or their pharmaceutically acceptable salts, pharmaceutical compositions containing them, and their medical uses. The compounds of the present disclosure have activity as Janus kinase (JAK) inhibitors and are useful in the in the treatment or control of inflammation, auto-immune diseases, cancer, and other disorders and indications where modulation of JAK would be desirable. Also described are methods of treating inflammation, auto-immune diseases, cancer, and other conditions that are susceptible to the inhibition of a Janus kinase by administering a compound herein described.

Abstract: A high ratio screw actuated device used as a press to provide high pressure under small increments of movement which includes a frame or base for a housing rotatably carrying a screw having large pitch threads, a nut within said housing receiving said screw and having internal threads of the same pitch as the screw threads but a pitch diameter larger than the screw pitch diameter, a thrust/radial bearing encompassing said nut, a compression spring in said housing urging said nut downward, the free end of said screw carrying one piece of a two-piece die set, a guide rod having one end received in a socket in the frame, and a motor mounted on the guide rod for slidable movement thereof, the upper end of the screw terminating in a coupling receiving the drive end of the motor to engage the screw in rotational movement.

Abstract: A double-gauge rail system for the rolling stock of railroad trains including pairs of rails of differing gauges, with the rail track sections of each gauge being in axial alignment but separate and not welded together at the section ends. The inner and outer rail sections of the two gauges at least partially overlap so that the inner rail sections extend across the gaps of the outer rail sections and, likewise, the outer rail sections extend across the gaps of the inner rail sections. To provide continuous contact between the wheels and rails sections, each axle of a vehicle car or engine has pairs of wheels on each end of the axle; the outer pair of wheels corresponding to the outer gauge and the inner pair of wheels corresponding to the inner gauge, so that the wheels of at least one rail gauge are in contact with the corresponding pair of rail sections.

Abstract: A device preferably mounted to the rear section of a vehicle such as from the vehicle rear axle for stabilizing the vehicle in turns and skids and providing improved overall holding power of the vehicle to the roadway. The stabilizer operates on a hydraulic principle and comprises a housing that may be partially liquid filled such as with a hydraulic oil, although the stabilizer also is operative with the use of solely an air fill. A substantial weight mass is disposed in the housing and is responsive to centrifugal force such as occasioned by a vehicle turn, particularly an abrupt turn, to cause displacement thereof axially of the housing. The device further comprises a piston at each end of the housing and a spring associated therewith for biasing the piston to a normal rest position. The piston has an aperture to permit fluid bleeding between opposite sides thereof to enhance stabilizer action.

Abstract: A device preferably mounted to the rear section of a vehicle such as from the vehicle rear axle for stabilizing the vehicle in turns and skids and providing improved overall holding power of the vehicle to the roadway. The stabilizer operates on a hydraulic principle and comprises a housing that may be partially liquid filled such as with a hydraulic oil, although the stabilizer also is operative with the use of solely an air fill. A substantial weight mass is disposed in the housing and is responsive to centrifugal force such as occasioned by a vehicle turn, particularly an abrupt turn, to cause displacement thereof axially of the housing. The device further comprises a piston at each end of the housing and means associated therewith for biasing the piston to a normal restposition, said piston having means permitting fluid bleeding between opposite sides thereof to enhance stabilizer action.

Abstract: The speed reducing mechanism is of simple construction and is easily adapted for providing different ratios of speed reduction, particularly a high ratio of speed reduction. The mechanism comprises inner and outer gears in planar engagement and a non-rotatable shifter member. In alternate embodiments, either the inner gear or the outer ring gear may be rotatable. In one disclosed embodiment the inner gear is driven by the input shaft under control of the shifter member to engage at its periphery with the ring gear causing the ring gear to be driven thereby. The inner gear tracks within the ring gear but is maintained non-rotatable by the shifter member. The gear ratio is a function of the number of teeth externally on the inner gear in comparison with the number of internal teeth on the ring gear. The closer in number the teeth, the higher the reduction ratio. In another embodiment the speed reducer is in the form of a hand operated winch.

Abstract: The sprocket drive chain of this invention is particularly adapted for right angle drive but may also be used for straight or various other angular drive situations. The construction lends itself to ease of manufacture and especially for the automated manufacture of chain. In the preferred embodiment the chain comprises interlocked links rotatably coupled, such as by a pin and bushing combination, with stamped side plates to provide an intermediate tooth (sprocket) opening. The successive openings are adapted to receive a tooth at opposite 90.degree. angles thus readily being adapted to a right angle drive. Other embodiments employ a common pivot to support the side plates in successive 90.degree. opposite directions, and a single plate version useable with a slotted tooth sprocket.

Abstract: The sprocket drive chain of this invention is particularly adapted for right angle drive but may also be used for straight or various other angular drive situations. The construction lends itself to ease of manufacture and especially for the automated manufacture of chain. In the preferred embodiment the chain comprises interlocked links rotatably coupled, such as by a pin and bushing combination, with stamped side plates to provide an intermediate tooth (sprocket) opening. The successive openings are adapted to receive a tooth at opposite 90.degree. angles thus readily being adapted to a right angle drive. Other embodiments employ a common pivot to support the side plates in successive 90.degree. opposite directions, and a single plate version useable with a slotted tooth sprocket.