Patents by Inventor Alan Rein

Alan Rein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Identification of anti-HIV compounds inhibiting virus assembly and binding of nucleocapsid protein to nucleic acid
    Patent number: 7572828
    Abstract: The invention provides methods and pharmaceutical compositions for inhibiting viral replication, particularly retroviral replication. The methods comprise administration of stibonic acid or diphenyl compounds that disrupt viral nucleocapsid binding to nucleic acids.
    Type: Grant
    Filed: October 8, 2003
    Date of Patent: August 11, 2009
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Robert H. Shoemaker, Michael Currens, Alan Rein, Hang Yuan, legal representative, Robert Fisher, Andrew Stephen, Karen Worthy, Shizuko Sei, Bruce Crise, Louis E. Henderson, Ya-Xiong Feng
  • Identification of anti-hiv compounds inhibiting virus assembly and binding of nucleocapsid protein to nucleic acid
    Publication number: 20060263772
    Abstract: The invention provides methods and pharmaceutical compositions for inhibiting viral replication, particularly retroviral replication. The methods comprise administration of stibonic acid or diphenyl compounds that disrupt viral nucleocapsid binding to nucleic acids.
    Type: Application
    Filed: October 8, 2003
    Publication date: November 23, 2006
    Applicant: The Government of the USA as Represented by the Secretary of the Dept. of Health and Human Service
    Inventors: Robert Shoemaker, Michael Currens, Alan Rein, Ya-Xiong Feng, Robert Fisher, Andrew Stephen, Karen Worthy, Shizuko Sei, Bruce Crise, Louis Henderson
  • Oligonucleotides which specifically bind retroviral nucleocapsid proteins
    Patent number: 6316190
    Abstract: The invention provides oligonucleotides which bind to retroviral nucleocapsid proteins with high affinity, molecular decoys for retroviral nucleocapsid proteins which inhibit viral replication, targeted molecules comprising high affinity oligonucleotides, assays for selecting test compounds, and related kits.
    Type: Grant
    Filed: July 12, 1999
    Date of Patent: November 13, 2001
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Alan Rein, Jose Casas-Finet, Robert Fisher, Matthew Fivash, Louis E. Henderson
  • Design and construction of non-infectious human retroviral mutants deficient in genomic RNA
    Patent number: 5674720
    Abstract: The present invention defines a biological role for the following sequence of amino acids that is found in the nucleocapsid domain of the gag precursor polyproteins of all replication-competent retroviruses:-Cys-X-X-Cys-X-X-X-X-His-X-X-X-X-Cys-wherein X represents variable amino acids. The invariant residues constitute part of a vital protein structure, at least one of which are found in all retroviruses and which are involved in the selection and packaging of genomic viral RNA into infectious virus particles. Disruption of this structure leads to the formation of virus-like particles which appear to be structurally normal, but which do not contain the normal complement of viral RNA. Therefore, their infectivity is drastically reduced or completely eliminated.
    Type: Grant
    Filed: January 3, 1994
    Date of Patent: October 7, 1997
    Assignee: United States of America
    Inventors: Robert J. Gorelick, Larry O. Arthur, Alan Rein, Louis E. Henderson, Stephen Oroszlan