Abstract: Processes and systems are described for solvent extraction of bitumen from oil sands. Fines agglomeration is employed to simplify subsequent separation. A high quality bitumen product can be formed, which meets or exceeds downstream processing and pipeline requirements. An embodiment comprises combining a first solvent and a bituminous feed to form an initial slurry, which is optionally separated into fine solids and coarse solids. Slurry solids are agglomerated. A low solids bitumen extract from the agglomerated slurry is mixed with a second solvent having a similar or lower boiling point than the first. The mixture is separated, solvent recovered, and a high grade bitumen product is formed. Exemplary systems comprise a mixbox, agglomerator, separator unit with optional countercurrent washer and deep cone settler, and TSRU. Processes are provided for fractionating a hydrocarbon fluid into heavier and lighter fractions. The lighter fraction may be used in solvent extraction of bitumen.

Abstract: Substrates may be coated with copolymers of N-vinyl pyrrolidinone and aryl ketones. Processes are described for making the copolymers at high molecular weight with the ketones randomly dispersed on the copolymer.

Abstract: Certain embodiments include carbonate esters of rapamycin at position 42 that are synthesized by a lipase catalyzed regio-specific process. These compounds or a pharmaceutically acceptable salt thereof are useful in the treatment of organ and tissue transplant rejection, autoimmune disease, proliferative disorder, restenosis, cancer, or microbial infection.

Abstract: An apparatus for treating patients using electrical interferential therapy is disclosed. The apparatus uses multiple electrodes to define multiple treatment channels, with each channel having a discrete frequency and an adjustable beat frequency between all or selected channel pairs. This adjustment can be done between treatment sessions or can be done during the treatment session by the technician or by the apparatus as programmed. The multiple treatment channels can be used on the same patient, or can be used by the same or a different technician to treat additional patient(s).

Abstract: An apparatus for treating patients using electrical interferential therapy is disclosed. The apparatus uses multiple electrodes to define multiple treatment channels, with each channel having a discrete frequency and an adjustable beat frequency between all or selected channel pairs. This adjustment can be done between treatment sessions or can be done during the treatment session by the technician or by the apparatus as programmed. The multiple treatment channels can be used on the same patient, or can be used by the same or a different technician to treat additional patient(s).

Abstract: The present invention relates to a method for the extraction of sesquiterpene lactones from the plant Tanacetum parthenium specifically using polar organic solvents and the use of such extracts in pharmaceutical products. It has been found that by utilization of an extraction procedure in accordance with the current invention, a significantly greater amount of the sesquiterpene lactone parthenolide is extracted from Tanacetum parthenium than is the case when using petroleum spirit as the primary extractant, the solvent usually used in previous studies.

Abstract: A pharmaceutical composition which comprises particles of a finely divided pharmaceutically acceptable water soluble diluent coated with microcrystalline particles of nifedipine, the majority of which have a particle size of 100 micrometers or less in the presence of polyvinyl-pyrrolidone, the polyvinylpyrrolidone being present in an amount of from 10 to 90% by weight based on the weight of the nifedipine. The incorporation of polyvinylpyrrolidone in an amount of less than the amount of nifedipine significantly slows the dissolution of nifedipine from the finished solid dosage form.

Abstract: A slow release formulation to be administered to humans or animals, comprising primary granules which contain an active ingredient and are in a secondary matrix of a water soluble/dispersible slow release material, the granules themselves comprising particles containing the active ingredients and in a primary matrix of a water soluble/dispersible slow release material.Optionally the formulation comprises a binder phase of a water insoluble slow release material having embedded therein secondary granules comprising the secondary matrix containing the primary matrix granules.The water soluble/dispersible material may be a polysaccharide and acacia and low viscosity methylcellulose are exemplified, as well as alginate and gelatine.

Abstract: A preparation for percutaneous administration of nitroglycerine, said preparation comprising nitroglycerine incorporated in a cream base in an amount not less than about 0.05% by weight based on the total weight of the preparation. The composition may also contain other medicaments, the bioavailability of which is enhanced by the nitroglycerine. The action of the preparation against for example angina may be brought about by having an appropriate amount of nitroglycerine or as additional medicament another medicament active against angina. The preparation may contain an hydroxyalkylcellulose which may provide, in combination with a waxy component in the cream, for example a higher aliphatic alcohol, a prolonged release effect. The preparation has advantages particularly as regards bioavailability over prior uniphasic ointments.

Abstract: A preparation for percutaneous administration of nitroglycerine, said preparation comprising nitroglycerine incorporated in a cream base in an amount not less than about 0.05% by weight based on the total weight of the preparation. The composition may also contain other medicaments, the bioavailability of which is enhanced by the nitroglycerine. The action of the preparation against for example angina may be brought about by having an appropriate amount of nitroglycerine or as additional medicament another medicament active against angina. The preparation may contain an hydroxyalkylcellulose which may provide, in combination with a waxy component in the cream, for example a higher aliphatic alcohol, a prolonged release effect. The preparation has advantages particularly as regards bioavailability over prior uniphasic ointments.