Patents by Inventor Alan Richard BROOKS

Alan Richard BROOKS has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210348159
    Abstract: Provided herein are compositions, methods, and systems for targeted delivery of nucleic acids, including DNA and RNA, to a target cell. Also provided are compositions, methods, and systems for expressing a transgene in a cell by genomic editing. Further provided are compositions, methods, and systems for knocking in a gene-of-interest (GOI) into a target genomic locus in the genome, in particular the locus of albumin gene. Also provided are compositions, methods, and systems for treating a subject having or suspected of having a disorder or health condition employing ex vivo and/or in vivo genome editing.
    Type: Application
    Filed: October 17, 2019
    Publication date: November 11, 2021
    Inventors: Alan Richard Brooks, Karen Vo
  • Publication number: 20210254057
    Abstract: Provided include compositions, methods, and systems for modulating the expression, function, and/or activity of a target gene, for example a blood-clotting protein such as Factor VIII (FVIII), in a cell by genome editing. Also provided include compositions, methods, and systems for treating a subject having or suspected of having a disorder or health condition, e.g., Hemophilia A, employing ex vivo and/or in vivo genome editing.
    Type: Application
    Filed: January 11, 2019
    Publication date: August 19, 2021
    Applicants: CRISPR Therapeutics AG, BAYER HEALTHCARE LLC
    Inventors: Alan Richard Brooks, Karen VO
  • Publication number: 20210187125
    Abstract: Provided include materials and methods for treating Hemophilia A in a subject ex vivo or in vivo. Also provided include materials and methods for knocking in a FVIII-encoding gene in a genome, in particular the locus of albumin gene.
    Type: Application
    Filed: October 17, 2018
    Publication date: June 24, 2021
    Inventor: Alan Richard Brooks
  • Publication number: 20210130824
    Abstract: Provided include compositions, methods, and systems for modulating the expression, function, and/or activity of a target gene, for example a blood-clotting protein such as Factor VIII (FVIII), in a cell by genome editing. Also provided include compositions, methods, and systems for treating a subject having or suspected of having a disorder or health condition, e.g., hemophilia A, employing ex vivo and/or in vivo genome editing.
    Type: Application
    Filed: February 15, 2019
    Publication date: May 6, 2021
    Applicants: CRISPR Therapeutics AG, BAYER Healthcare LLC
    Inventor: Alan Richard Brooks
  • Publication number: 20200384125
    Abstract: Provided herein, in some embodiments, are materials and methods for treating hemophilia A in a subject ex vivo or in vivo. Also provided herein, in some embodiments, are materials and methods for knocking in a coding sequence encoding a synthetic FVIII having a B domain substitute into a genome.
    Type: Application
    Filed: April 15, 2020
    Publication date: December 10, 2020
    Applicants: CRISPR THERAPEUTICS AG, BAYER HEALTHCARE LLC
    Inventor: Alan Richard Brooks
  • Publication number: 20190247517
    Abstract: Provided include materials and methods for treating Hemophilia A in a subject ex vivo or in vivo. Also provided include materials and methods for knocking in a FVIII-encoding gene in a genome, in particular the locus of albumin gene.
    Type: Application
    Filed: October 17, 2018
    Publication date: August 15, 2019
    Inventor: Alan Richard BROOKS