Abstract: Disclosed herein are novel compounds of Formula (1) and pharmaceutically acceptable salts thereof, pharmaceutical compositions containing the same, and methods of using the same.

Abstract: We provide compounds that may be useful as CPS1 inhibitors. These compounds may be useful, for example, in the treatment of cancer.

Abstract: A magnetic particle-polymer hybrid material can include: a substance having a structure of Formula 1 or derivative or salt thereof: Z(L-FP)m (Formula 1), wherein: Z is a magnetic particle smaller than 1 mm; m is a positive integer and defines the number of (L-FP) coupled to the Z; L is a linker linked to the magnetic particle; FP is a functionalized polymer having: a first structure derived from a first norbornene compound linked to the magnetic particle through the L; and one or more monomeric units each including a second structure derived from a second norbornene compound, where one of the monomeric units is linked to the first structure through a saturated or unsaturated alkyl, each monomeric unit includes a functional group capable of binding with another substance.

Abstract: A magnetic particle-polymer hybrid material can include: a substance having a structure of Formula 1 or derivative or salt thereof: Z(L-FP)m (Formula 1), wherein: Z is a magnetic particle smaller than 1 mm; m is a positive integer and defines the number of (L-FP) coupled to the Z; L is a linker linked to the magnetic particle; FP is a functionalized polymer having: a first structure derived from a first norbornene compound linked to the magnetic particle through the L; and one or more monomeric units each including a second structure derived from a second norbornene compound, where one of the monomeric units is linked to the first structure through a saturated or unsaturated alkyl, each monomeric unit includes a functional group capable of binding with another substance.

Abstract: A magnetic particle-polymer hybrid material can include: a substance having a structure of Formula 1 or derivative or salt thereof: Z(Y-Triazole-CH2—X—CH2—(FP)n)m (Formula 1), wherein Z is a magnetic particle smaller than 1 mm; n and m are independently integers; Y includes a first linker having an alkyl and/or aryl linked to the magnetic particle; X is CH2 or a heteroatom; FP is a functionalized polymer having: a first structure derived from a first norbornene compound linked to the magnetic particle through the Y-Triazole-CH2—X—CH2 linker; and one or more monomeric units each including a second structure derived from a second norbornene compound, where one of the monomeric units is linked to the first structure through a saturated or unsaturated alkyl, each monomeric unit includes a functional group capable of binding with another substance.

Abstract: A particle-polymer hybrid material can include: a substance having the structure of Formula 1 Z(Y-FP)m, wherein Z is a particle smaller than 1 mm; m is an integer; Y is a linker including a silicon atom linked to the particle; FP is a functionalized polymer having: a first structure derived from a first norbornene compound linked to the Y; and one or more repeating units linked to the first structure, each unit being derived from a second norbornene compound and having a functional group.

Abstract: A magnetic particle-polymer hybrid material can include: a substance having a structure of Z-(Y-Triazole-X-(FP)n)m, (Formula 1), wherein Z is a magnetic particle smaller than 1 mm; n and m are independently integers; Y includes an alkyl or aryl linker linked to the magnetic particle; X is a carbon or heteroatom; FP is a functionalized polymer having: a first norbornenyl reaction product linked to the magnetic particle through the Y-Triazole-X linker; and one or more monomers each including a second norbornenyl reaction product, where one of the monomers is linked to the first norbornenyl reaction product, each monomer include a functional group capable of binding with another substance.

Abstract: A particle-polymer hybrid material can include: a substance having the structure of Formula 1 (Z—(Y—FP)m, wherein Z is a particle smaller than 1 mm; m is an integer; Y is a linker including a siloxane linked to the particle; FP is a functionalized polymer having: a first norbornenyl reaction product linked to the siloxane; and one or more second norbornenyl reaction products linked to the first norbornenyl reaction product opposite of the siloxane, wherein the one or more second norbornenyl reaction products include a functional group.