Patents by Inventor Alan Siu Lun Wong

Alan Siu Lun Wong has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IMPROVED HIGH-THROUGHPUT COMBINATORIAL GENETIC MODIFICATION SYSTEM AND OPTIMIZED CAS9 ENZYME VARIANTS
    Publication number: 20230193251
    Abstract: The present invention provides to an improved high-throughput system and method for generated and screening of genetic variants by combinatorial modifications. Also provided are optimized SpCas9 enzyme variants produced by this system.
    Type: Application
    Filed: September 17, 2019
    Publication date: June 22, 2023
    Inventors: Alan Siu Lun Wong, Gigi Ching Gee Choi
  • MASSIVELY PARALLEL COMBINATORIAL GENETICS FOR CRISPR
    Publication number: 20210310022
    Abstract: Described herein are methods and compositions that enable rapid generation of high-order combinations of genetic elements comprising a CRISPR guide sequence and a scaffold sequence, and a barcode for rapid identification of the combination of genetic elements encoded within a single cell or a pooled population. Also described herein compositions of inhibitors of epigenetic genes and methods for reducing cell proliferation and/or treating cancer.
    Type: Application
    Filed: June 3, 2021
    Publication date: October 7, 2021
    Applicant: Massachusetts Institute of Technology
    Inventors: Timothy Kuan-Ta Lu, Alan Siu Lun Wong, Ching Gee Choi
  • MASSIVELY PARALLEL COMBINATORIAL GENETICS FOR CRISPR
    Publication number: 20190100769
    Abstract: Described herein are methods and compositions that enable rapid generation of high-order combinations of genetic elements comprising a CRISPR guide sequence and a scaffold sequence, and a barcode for rapid identification of the combination of genetic elements encoded within a single cell or a pooled population. Also described herein compositions of inhibitors of epigenetic genes and methods for reducing cell proliferation and/or treating cancer.
    Type: Application
    Filed: October 30, 2015
    Publication date: April 4, 2019
    Applicant: Massachusetts Institute of Technology
    Inventors: Timothy Kuan-Ta Lu, Alan Siu Lun Wong, Ching Gee Choi
  • MICRORNA COMBINATIONS FOR ANTI-CANCER THERAPEUTICS
    Publication number: 20170369878
    Abstract: Described herein are methods and compositions of combinations of microRNAs that enhance the sensitivity of cancer cells to chemotherapeutic agents or reduce proliferation of cancer cells. Also described herein are methods for the identification of combinations of microRNAs that result in desired effects.
    Type: Application
    Filed: January 11, 2016
    Publication date: December 28, 2017
    Applicant: Massachusetts Institute of Technology
    Inventors: Timothy Kuan-Ta Lu, Alan Siu Lun Wong, Ching Gee Choi