Abstract: Described herein are modified integrin ? and/or ? headpiece polypeptides, and crystallizable integrin polypeptide dimers comprising a modified integrin ? and/or ? headpiece polypeptide and a disulfide bond linking the two integrin headpiece polypeptide subunits. Methods for using the modified integrin ? and/or ? headpiece polypeptides and the integrin polypeptide dimers are also provided herein. For example, methods for characterizing integrin-ligand interaction and identifying integrin ligands are also provided herein. In some embodiments, the identified integrin ligands can be used as inhibitors of integrins.

Abstract: Described herein are modified integrin ? and/or ? headpiece polypeptides, and crystallizable integrin polypeptide dimers comprising a modified integrin ? and/or ? headpiece polypeptide and a disulfide bond linking the two integrin headpiece polypeptide subunits. Methods for using the modified integrin ? and/or ? headpiece polypeptides and the integrin polypeptide dimers are also provided herein. For example, methods for characterizing integrin-ligand interaction and identifying integrin ligands are also provided herein. In some embodiments, the identified integrin ligands can be used as inhibitors of integrins.

Abstract: Disclosed are compositions and methods for modulating the activity of TGF-?. More particularly, compositions and methods for modulating the release of active TGF-? from an LRRC33-TGF-? prodomain-TGF-? ternary complex are provided, as are and methods of treatment based upon such modulation.

Abstract: Described herein are modified integrin ? and/or ? headpiece polypeptides, and crystallizable integrin polypeptide dimers comprising a modified integrin ? and/or ? headpiece polypeptide and a disulfide bond linking the two integrin headpiece polypeptide subunits. Methods for using the modified integrin ? and/or ? headpiece polypeptides and the integrin polypeptide dimers are also provided herein. For example, methods for characterizing integrin-ligand interaction and identifying integrin ligands are also provided herein. In some embodiments, the identified integrin ligands can be used as inhibitors of integrins.

Abstract: Described herein are modified integrin ? and/or ? headpiece polypeptides, and crystallizable integrin polypeptide dimers comprising a modified integrin ? and/or ? headpiece polypeptide and a disulfide bond linking the two integrin headpiece polypeptide subunits. Methods for using the modified integrin ? and/or ? headpiece polypeptides and the integrin polypeptide dimers are also provided herein. For example, methods for characterizing integrin-ligand interaction and identifying integrin ligands are also provided herein. In some embodiments, the identified integrin ligands can be used as inhibitors of integrins.

Abstract: The present invention provides growth factor-directed agents (GDAs), which act as either antagonists or agonists of cell signaling, particularly in the TGF-beta and related extracellular matrix signaling pathways. Such GDAs include monoclonal antibodies, fusion proteins and novel polypeptide compositions and/or conjugates of these compositions.

Abstract: Disclosed are compositions and methods for modulating the activity of TGF-?. More particularly, compositions and methods for modulating the release of active TGF-? from an LRRC33-TGF-? prodomain-TGF? ternary complex are provided, as are and methods of treatment based upon such modulation.

Abstract: A method for remediating Frac water and other emulsions created during hydraulic fracturing includes storing contaminated Frac water in a first collection unit, operating at least one pumping unit to pump a portion of the contaminated Frac water, and storing remediated Frac water in a second collection unit. A microwave separation technology (“MST”) unit, an ultra-violet light remediation (“UVLR”) unit, and a chemical additive unit are used to reduce contamination levels of the contaminated Frac water. The MST unit can work alone, or in combination with the UVLR unit, the chemical additive unit, or both, to further reduce contamination levels of the contaminated Frac water. A system operating according to the method can be deployed at an onsite drilling facility or at a centralized offsite location. By reusing remediated Frac water, entities can realize significant cost savings and better environmental compliance.

Abstract: Described herein are modified integrin ? and/or ? headpiece polypeptides, and crystallizable integrin polypeptide dimers comprising a modified integrin ? and/or ? headpiece polypeptide and a disulfide bond linking the two integrin headpiece polypeptide subunits. Methods for using the modified integrin ? and/or ? headpiece polypeptides and the integrin polypeptide dimers are also provided herein. For example, methods for characterizing integrin-ligand interaction and identifying integrin ligands are also provided herein. In some embodiments, the identified integrin ligands can be used as inhibitors of integrins.

Abstract: Described herein are modified integrin ? and/or ? headpiece polypeptides, and crystallizable integrin polypeptide dimers comprising a modified integrin ? and/or ? headpiece polypeptide and a disulfide bond linking the two integrin headpiece polypeptide subunits. Methods for using the modified integrin ? and/or ? headpiece polypeptides and the integrin polypeptide dimers are also provided herein. For example, methods for characterizing integrin-ligand interaction and identifying integrin ligands are also provided herein. In some embodiments, the identified integrin ligands can be used as inhibitors of integrins.

Abstract: A method for remediating Frac water and other emulsions created during hydraulic fracturing includes storing contaminated Frac water in a first collection unit, operating at least one pumping unit to pump a portion of the contaminated Frac water, and storing remediated Frac water in a second collection unit. A microwave separation technology (“MST”) unit, an ultra-violet light remediation (“UVLR”) unit, and a chemical additive unit are used to reduce contamination levels of the contaminated Frac water. The MST unit can work alone, or in combination with the UVLR unit, the chemical additive unit, or both, to further reduce contamination levels of the contaminated Frac water. A system operating according to the method can be deployed at an onsite drilling facility or at a centralized offsite location. By reusing remediated Frac water, entities can realize significant cost savings and better environmental compliance.

Abstract: The present invention provides growth factor-directed agents (GDAs), which act as either antagonists or agonists of cell signaling, particularly in the TGF-beta and related extracellular matrix signaling pathways. Such GDAs include monoclonal antibodies, fusion proteins and novel polypeptide compositions and/or conjugates of these compositions.

Abstract: Described is an improved method and system for remediating Frac water and other emulsions created during hydraulic fracturing. The system can include a first collection unit adapted to store contaminated Frac water, at least one pumping unit adapted to pump a portion of the contaminated Frac water, and a second collection unit for storing remediated Frac water. The system can further include a microwave separation technology (“MST”) unit, an ultra-violet light remediation (“UVLR”) unit, and a chemical additive unit adapted to reduce contamination levels of the contaminated Frac water. The MST unit can work alone, or in combination with the UVLR unit, the chemical additive unit, or both, to further reduce contamination levels of the contaminated Frac water. The system can be deployed at an onsite drilling facility or at a centralized offsite location. By reusing remediated Frac water, entities can realize significant cost savings and better environmental compliance.

Abstract: Described is an improved method and system for remediating Frac water and other emulsions created during hydraulic fracturing. The system can include a first collection unit adapted to store contaminated Frac water, at least one pumping unit adapted to pump a portion of the contaminated Frac water, and a second collection unit for storing remediated Frac water. The system can further include a microwave separation technology (“MST”) unit, an ultra-violet light remediation (“UVLR”) unit, and a chemical additive unit adapted to reduce contamination levels of the contaminated Frac water. The MST unit can work alone, or in combination with the UVLR unit, the chemical additive unit, or both, to further reduce contamination levels of the contaminated Frac water. The system can be deployed at an onsite drilling facility or at a centralized offsite location. By reusing remediated Frac water, entities can realize significant cost savings and better environmental compliance.

Abstract: Provided are a method, system, and program for managing communication code changes between processors in which a local processor sends remote operation requests to be executed by a remote processor. In the illustrated embodiment, the local processor and the remote processor each have a control set for managing transfers of remote operation requests. The remote processor control set includes a queue for queuing remote operation requests awaiting execution. The control set of the local processor includes a credit counter which keeps track of permissible outstanding remote operation requests. The remote processor populates a configuration structure with information concerning the remote processor control set including the size of the queue and sends the configuration structure to the local processor. The local processor extracts the information from the configuration structure and configures the local processor control set.

Abstract: Provided are a method, system, and program for managing resources in which a local processor sends remote operation requests to be executed by a remote processor having multiple resources. In the illustrated embodiment, the local processor and the remote processor each have a resource manager, each of which maintains a control set for each resource of the remote processor. Each control set of the remote processor resource manager includes a queue for queuing remote operation requests awaiting execution in connection with the resource associated with the control set. Each control set of the local processor resource manager includes a credit counter which keeps track of permissible outstanding remote operation requests. Each local processor control set credit counter is decremented for each remote operation request for the associated resource sent to the remote processor and is incremented for each acknowledgment received from the remote processor.

Abstract: Provided are a method, system, and program for managing data. A data request is received to a target track in a relationship, wherein the relationship associates a source track with the target track. A destage request to destage the source track is submitted in response to the data request to the target track, wherein executing the data request to the target track is conditioned on receiving a completion response to the destage request. If the source track is not in cache, then a complete response is returned to the destage request. If the source track was in cache when the relationship was established, then the destage request is added to an Input/Output (I/O) queue for the source track. After the source track is destaged in response to processing the destage request in the I/O queue, the complete response is returned to the destage request.

Abstract: Provided are a method, system, and program for managing data. A data request is received to a target track in a relationship, wherein the relationship associates a source track with the target track. A destage request to destage the source track is submitted in response to the data request to the target track, wherein executing the data request to the target track is conditioned on receiving a completion response to the destage request. If the source track is not in cache, then a complete response is returned to the destage request. If the source track was in cache when the relationship was established, then the destage request is added to an Input/Output (I/O) queue for the source track. After the source track is destaged in response to processing the destage request in the I/O queue, the complete response is returned to the destage request.

Abstract: Provided are a method, system, and program for managing resources in which a local processor sends remote operation requests to be executed by a remote processor having multiple resources. In the illustrated embodiment, the local processor and the remote processor each have a resource manager, each of which maintains a control set for each resource of the remote processor. Each control set of the remote processor resource manager includes a queue for queuing remote operation requests awaiting execution in connection with the resource associated with the control set. Each control set of the local processor resource manager includes a credit counter which keeps track of permissible outstanding remote operation requests. Each local processor control set credit counter is decremented for each remote operation request for the associated resource sent to the remote processor and is incremented for each acknowledgment received from the remote processor.

Abstract: Provided are a method, system, and program for managing communication code changes between processors in which a local processor sends remote operation requests to be executed by a remote processor. In the illustrated embodiment, the local processor and the remote processor each have a control set for managing transfers of remote operation requests. The remote processor control set includes a queue for queuing remote operation requests awaiting execution. The control set of the local processor includes a credit counter which keeps track of permissible outstanding remote operation requests. The remote processor populates a configuration structure with information concerning the remote processor control set including the size of the queue and sends the configuration structure to the local processor. The local processor extracts the information from the configuration structure and configures the local processor control set.