Patents by Inventor Alan T. Hudson
Alan T. Hudson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5770598Abstract: The present invention relates to heterocyclic compounds which have been found to have anti-tumour activity. More specifically, the invention concerns Pyrrolo ?3,2-b! carbazoles, 1H-Benzofuro ?3,2-.function.! indoles and 1H-?1! Benzothieno ?2,3-.function.! indoles, methods for their preparation, pharmaceutical formulations containing them and their use as anti-tumour agents.Type: GrantFiled: April 10, 1997Date of Patent: June 23, 1998Assignee: University College Cardiff Consultants LimitedInventors: David D. Miller, Paul Barraclough, Sadie Vile, Ann L. Walker, Patrick V. R. Shannon, Laddawan Chunchatprasert, Pierre P. M. Debont, Alan T. Hudson
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Patent number: 5567738Abstract: The present invention relates to the use of 2-[4-(4-chlorophenyl)cyclohexyl]-3-hydroxy-1,4-naphthoquinone or a physiologically acceptable salt or other physiologically functional derivative thereof for the manufacture of a medicament for the treatment of tumours in animals, to pharmaceutical compositions for the treatment of tumours in animals, to pharmaceutical compositions for the treatment of tumours, comprising said compound as active ingredient and to a method of treating tumours in an animal which comprises administering to said animal an effective amount of said compound.Type: GrantFiled: January 31, 1995Date of Patent: October 22, 1996Assignee: Glaxo Wellcome Inc.Inventor: Alan T. Hudson
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Patent number: 5561164Abstract: The present invention relates to pharmaceutical compositions for the treatment of infections caused by Microsporidia comprising treating an animal with 2-[4-(4-chlorophenyl)cyclohexyl]-3-hydroxy-1,4-naphthoquinone or a physiologically acceptable salt thereof.Type: GrantFiled: June 9, 1995Date of Patent: October 1, 1996Assignee: Glaxo Wellcome Inc.Inventors: Winston E. Gutteridge, Alan T. Hudson, Victoria S. Latter, Mary Pudney
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Patent number: 5559156Abstract: The present invention relates to pharmaceutical compositions for the treatment and/or prophylaxis of protozoal infections caused by Kinetoplastida, Apicomplexa, Anaerobic protozoa and Mircosporidia comprising 2-[4-(4-chlorophenyl)cyclohexyl]-3-hydroxy-1,4-naphthoquinone or a physiologically acceptable salt or other functional derivative thereof as active ingredient and to a method of treating or preventing siad protozoal infections in an animal which comprises administering to said animal an effective amount of siad compound.Type: GrantFiled: November 8, 1994Date of Patent: September 24, 1996Assignee: Glaxo Wellcome, Inc.Inventors: Winston E. Gutteridge, Alan T. Hudson, Victoria S. Latter, Mary Pudney
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Patent number: 5537947Abstract: An expendable underwater vehicle for use in training naval forces in anti-submarine warfare in ocean waters, including shallow waters, is between about three to five feet in length and about five inches in diameter, and it includes various improvements which make successful operations in shallow ocean waters, and improved operation in all ocean waters, possible. The improvements include a one-piece nose cup which allows the expendable underwater vehicle to be air launched into shallow water, a scuttle plug which allows water to fill the expendable underwater vehicle after the vehicle is expended and drops to the bottom of the ocean, and rudders and elevators of increased surface area which improve controllability of the vehicle in the water.Type: GrantFiled: October 24, 1994Date of Patent: July 23, 1996Assignee: Sippican, Inc.Inventors: John R. Couture, Alan T. Hudson, Michael J. Balboni, Mark C. Manning, Patrick J. Kelly, Brian J. Gallagher
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Patent number: 5466711Abstract: A method for treating or preventing a Pneumocystis carinii infection in a mammal by administering a certain naphthoquinone compound or physiologically acceptable salts thereof.Type: GrantFiled: May 20, 1992Date of Patent: November 14, 1995Assignee: Burroughs Wellcome Co.Inventors: Victoria S. Latter, Winston E. Gutteridge, Alan T. Hudson
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Patent number: 5310762Abstract: A method for treating or preventing a Pneumocystis carinii infection in a mammal by administering a certain naphthoquinone compound or physiologically acceptable salts thereof.Type: GrantFiled: November 22, 1991Date of Patent: May 10, 1994Assignee: Burroughs Wellcome Co.Inventors: Victoria S. Latter, Winston E. Gutteridge, Alan T. Hudson
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Patent number: 5206268Abstract: A method for treating or preventing a Pneumocystis carinii infection in a mammal by administering a certain naphthoquinone compound or physiologically acceptable salts thereof.Type: GrantFiled: August 15, 1989Date of Patent: April 27, 1993Assignee: Burroughs Wellcome Co.Inventors: Victoria S. Latter, Winston E. Gutteridge, Alan T. Hudson
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Patent number: 5175319Abstract: Novel antiprotozoal naphthoquinones having the general formula ##STR1## (wherein either R.sup.1 is hydrogen and R.sup.2 is selected from C.sub.1-6 alkoxy, aralkoxy, C.sub.1-6 alkyl-C.sub.1-6 alkoxy, phenyl substituted by one or two groups selected from halogen and C.sub.1-6 alkyl, halogen and perhalo-C.sub.1-6 alkyl; or R.sup.1 and R.sup.2 are both C.sub.1-6 alkyl or phenyl; and n is 0 or 1) and salt thereof. The compounds of formula (I) are useful for the treatment or prophylaxis of protozoal diseases including malaria, theileriosis and coccidiosis. Various processes for preparing compounds of formula (I) are described.Type: GrantFiled: September 12, 1991Date of Patent: December 29, 1992Assignee: Burroughs Wellcome Co.Inventors: Alan T. Hudson, Anthony W. Randall
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Patent number: 5053432Abstract: Novel antiprotozoal naphthoquinones having the general formula ##STR1## (wherein either R.sup.1 is hydrogen and R.sup.2 is selected from C.sub.1-6 alkoxy, aralkoxy, C.sub.1-6 alkyl-C.sub.1-6 alkoxy, phenyl substituted by one or two groups selected from halogen and C.sub.1-6 alkyl, halogen and perhalo-C.sub.1-6 alkyl; or R.sup.1 and R.sup.2 are both C.sub.1-6 alkyl or phenyl; and n is 0 or 1) and salt thereof. The compounds of formula (I) are useful for the treatment or prophylaxis of protozoal diseases including malaria, theileriosis and coccidiosis. Various processes for preparing compounds of formula (I) are described.Type: GrantFiled: December 26, 1989Date of Patent: October 1, 1991Assignee: Burroughs Wellcome Co.Inventors: Alan T. Hudson, Anthony W. Randall
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Patent number: 5053418Abstract: Novel combinations of an antiprotozoal naphthoquinone and a 4-pyridinol or an alkanoic ester thereof wherein the antiprotozoal activity of the combination is potentiated with respect to the corresponding activity of the components of the combination. The combinations are especially useful for the treatment or porphylaxis of malaria.Type: GrantFiled: December 11, 1989Date of Patent: October 1, 1991Assignee: Burroughs Wellcome Co.Inventors: Victoria S. Latter, Alan T. Hudson, William H. G. Richards, Anthony W. Randall
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Patent number: 4673363Abstract: A sonobuoy having a terminal weight and sensor for deployment beneath the surface of the water after the buoy has been launched from an aircraft and impacted the water. A circuit assembly and antenna for processing output from the sensor and for transmitting a signal is provided. A cable for connecting the sensor and circuit assembly is also included. A housing for the sonobuoy is a blow molded seamless thermoplastic shell which surrounds the circuit assembly.Type: GrantFiled: November 8, 1985Date of Patent: June 16, 1987Assignee: Sippican Ocean Systems, Inc.Inventors: Alan T. Hudson, David P. Gagnon, David W. Johns, II, William J. Langenhein, Jr.
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Patent number: 4485116Abstract: 1,4-Naphthoquinones of formula (I), methods for their preparation, veterinary formulations thereof, and the use thereof in animal therapy are disclosed. ##STR1## Particularly preferred compounds of formula (I) are, 2-[trans-(4-t-butylcyclohexyl)methyl]-3-hydroxy-1,4-naphthoquinone, and 2-[trans-(4-t-pentyl cyclohexyl)methyl]3-hydroxy-1,4-naphthoquinone. The compounds are of value as anti-protozoal agents, in particular as anti-theilerial agents.Type: GrantFiled: October 13, 1982Date of Patent: November 27, 1984Inventors: Alan T. Hudson, Anthony W. Randall
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Patent number: 4485117Abstract: 1,4-Naphthoquinones of formula (I), methods for their preparation, pharmaceutical and veterinary formulations thereof and the use thereof in human and animal therapy are disclosed. ##STR1## Particularly preferred compounds of formula (I) are 2-(4'-t-butylcyclohexyl)-3-hydroxy-1,4-naphthoquinone and 2-hydroxy-3-(4'-t-pentylcyclohexyl)-1,4-naphthoquinone. The compounds are of value as antiprotozoal agents, in particular antimalarial and anticoccidial agents.Type: GrantFiled: October 13, 1982Date of Patent: November 27, 1984Inventors: Alan T. Hudson, Anthony W. Randall