Patents by Inventor Alan T. Johnson

Alan T. Johnson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230118692
    Abstract: Provided are devices and methods to detect the presence of volatile organic compounds related to the presence of a disease state in a biological sample. The devices may include a detection moiety such as a polynucleoide in electronic communication with a semiconductor such as graphene or a carbon nanotube.
    Type: Application
    Filed: June 28, 2022
    Publication date: April 20, 2023
    Inventors: Alan T. Johnson, Nicholas J. Kybert, George Preti, Katharine A. Prigge, Janos L. Tanyi, Cynthia Otto
  • Patent number: 11415546
    Abstract: Provided are devices and methods to detect the presence of volatile organic compounds related to the presence of a disease state in a biological sample. The devices may include a detection moiety such as a polynucleotide in electronic communication with a semiconductor such as graphene or a carbon nanotube.
    Type: Grant
    Filed: September 3, 2015
    Date of Patent: August 16, 2022
    Assignees: The Trustees of the University of Pennsylvania, Monell Chemical Senses Center
    Inventors: Alan T. Johnson, Nicholas J. Kybert, George Preti, Katharine A. Prigge, Janos L. Tanyi, Cynthia Otto
  • Patent number: 11299461
    Abstract: Compounds of formula I are provided: wherein X is NH, or CH2, Y is a single bond, or —CHR5—, R1 is H, C1-C4 alkyl, or C1-C4 hydroxyalkyl, R2 and R2? are each independently H, C1-C4 alkyl, or C1-C4 hydroxyalkyl, each R3 is independently H, halo, —CF3, C1-C4 alkyl, or C1-C4 alkoxy, C3 perhaloalkyl, each R4 is independently H, halo, or C1-C4 alkyl, R5 is C1-C4 alkoxy, r is integer from 0 to 3; and p is integer from 0 to 3.
    Type: Grant
    Filed: March 12, 2019
    Date of Patent: April 12, 2022
    Assignee: HAWAII BIOTECH, INC.
    Inventors: Guan-Sheng Jiao, Seong Jin Kim, Alan T. Johnson
  • Publication number: 20210371383
    Abstract: Compounds of formula I are provided: wherein X is NH, or CH2, Y is a single bond, or —CHR5—, R1 is H, C1-C4 alkyl, or C1-C4 hydroxyalkyl, R2 and R2? are each independently H, C1-C4 alkyl, or C1-C4 hydroxyalkyl, each R3 is independently H, halo, —CF3, C1-C4 alkyl, or C1-C4 alkoxy, C3 perhaloalkyl, each R4 is independently H, halo, or C1-C4 alkyl, R5 is C1-C4 alkoxy, r is integer from 0 to 3; and p is integer from 0 to 3.
    Type: Application
    Filed: March 12, 2019
    Publication date: December 2, 2021
    Inventors: Guan-Sheng JIAO, Seong Jin KIM, Alan T. JOHNSON
  • Patent number: 11046652
    Abstract: Compounds of Formula I are provided: R1 is —OR5, m is an integer from 0 to 5, n is an integer from 0 to 2, each R2 is independently selected from hydrogen, halogen, and alkyl, R3 is selected from hydrogen, alkyl, cycloalkyl, aryl, hydroxyalkyl, alkoxyalkyl, aryloxyalkyl, aralkyloxyalkyl, aralkyl, alkylaminoalkyl, dialkylaminoalkyl, aralkylaminoalkyl, and heterocycloalkyl, R5 is an alkyl, each R4 is independently hydrogen or alkyl, and each of R2, R3, R4, and R5 is independently optionally substituted. Compounds of Formula I are included in pharmaceutical compositions for the treatment of a subject exposed to a botulinum toxin.
    Type: Grant
    Filed: June 24, 2020
    Date of Patent: June 29, 2021
    Assignee: HAWAII BIOTECH, INC.
    Inventors: Guan-Sheng Jiao, Alan T. Johnson, Sean O'Malley, Seong Jin Kim
  • Publication number: 20200399223
    Abstract: Compounds of Formula I are provided: R1 is —OR5, m is an integer from 0 to 5, n is an integer from 0 to 2, each R2 is independently selected from hydrogen, halogen, and alkyl, R3 is selected from hydrogen, alkyl, cycloalkyl, aryl, hydroxyalkyl, alkoxyalkyl, aryloxyalkyl, aralkyloxyalkyl, aralkyl, alkylaminoalkyl, dialkylaminoalkyl, aralkylaminoalkyl, and heterocycloalkyl, R5 is an alkyl, each R4 is independently hydrogen or alkyl, and each of R2, R3, R4, and R5 is independently optionally substituted. Compounds of Formula I are included in pharmaceutical compositions for the treatment of a subject exposed to a botulinum toxin.
    Type: Application
    Filed: June 24, 2020
    Publication date: December 24, 2020
    Inventors: Guan-Sheng JIAO, Alan T. JOHNSON, Sean O'MALLEY, Seong Jin KIM
  • Patent number: 10809222
    Abstract: The present invention provides methods for fabricating field-effect devices and sensor arrays. The field of the invention also pertains to methods of using the sensors individually, in combination, and in array fashion to detect molecules. The present invention also provides for products produced by the methods of the present invention and for apparatuses used to perform the methods of the present invention.
    Type: Grant
    Filed: April 25, 2014
    Date of Patent: October 20, 2020
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Alan T. Johnson, Jin Xi, Ganghee Han, Mitchell Lerner, Jeffery G. Saven, Renyu Liu, Felipe Matsunaga, Jose Manuel Perez-Aguilar
  • Patent number: 10351431
    Abstract: Provided are methods for growing large-size, uniform graphene layers on planarized substrates using Chemical Vapor Deposition (CVD) at atmospheric pressure; graphene produced according to these methods may have a single layer content exceeding 95%. Field effect transistors fabricated by the inventive process have room temperature hole mobilities that are a factor of 2-5 larger than those measured for samples grown on commercially-available copper foil substrates.
    Type: Grant
    Filed: August 11, 2011
    Date of Patent: July 16, 2019
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Alan T. Johnson, Zhengtang Luo
  • Patent number: 9930777
    Abstract: The present invention provides methods for fabricating graphene workpieces. The present invention also provides for products produced by the methods of the present invention and for apparatuses used to perform the methods of the present invention.
    Type: Grant
    Filed: April 23, 2015
    Date of Patent: March 27, 2018
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Alan T. Johnson, Rajatesh R. Gudibande, Zhengqing John Qi
  • Publication number: 20170227491
    Abstract: Provided are devices and methods to detect the presence of volatile organic compounds related to the presence of a disease state in a biological sample. The devices may include a detection moiety such as a polynucleotide in electronic communication with a semiconductor such as graphene or a carbon nanotube.
    Type: Application
    Filed: September 3, 2015
    Publication date: August 10, 2017
    Inventors: Alan T. JOHNSON, Nicholas J. KYBERT, George PRETI, Katharine A. PRIGGE, Janos L. TANYI, Cynthia OTTO
  • Publication number: 20170048975
    Abstract: The present invention provides methods for fabricating graphene workpieces. The present invention also provides for products produced by the methods of the present invention and for apparatuses used to perform the methods of the present invention.
    Type: Application
    Filed: April 23, 2015
    Publication date: February 16, 2017
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: Alan T. JOHNSON, Rajatesh R. GUDIBANDE, Zhengqing John QI
  • Publication number: 20160123919
    Abstract: The present invention provides methods for fabricating field-effect devices and sensor arrays. The field of the invention also pertains to methods of using the sensors individually, in combination, and in array fashion to detect molecules. The present invention also provides for products produced by the methods of the present invention and for apparatuses used to perform the methods of the present invention.
    Type: Application
    Filed: April 25, 2014
    Publication date: May 5, 2016
    Applicant: The Trustees of The University of Pennsylvania
    Inventors: Alan T. JOHNSON, Jin XI, Ganghee HAN, Mitchell LERNER, Jeffery G. SAVEN, Renyu LIU, Felipe MATSUNAGA, Jose Manuel PEREZ-AGUILAR
  • Patent number: 9146209
    Abstract: The present invention provides a broad response single-stranded DNA-graphene chemical sensor device. The present invention also provides methods for improving the ability of graphene to work as a chemical sensor by using single-stranded DNA as a sensitizing agent.
    Type: Grant
    Filed: March 30, 2011
    Date of Patent: September 29, 2015
    Assignee: The Trustees Of The University Of Pennsylvania
    Inventors: Alan T. Johnson, Ye Lu, Brett R. Goldsmith, Nicholas John Kybert
  • Patent number: 8821745
    Abstract: Disclosed are graphene oxide membrane materials of high surface area, which membranes suitably have a surface area of above about 200 ?m and exhibit electrical conductivity in excess of about 200 S/m. Also provided are methods of synthesizing such membranes, as well as devices and sensors that incorporate these novel grapheme materials.
    Type: Grant
    Filed: December 4, 2009
    Date of Patent: September 2, 2014
    Assignee: The Trustees Of The University Of Pennsylvania
    Inventors: Zhengtang Luo, Alan T. Johnson
  • Publication number: 20130217222
    Abstract: Provided are methods for growing large-size, uniform graphene layers on planarized substrates using Chemical Vapor Deposition (CVD) at atmospheric pressure; graphene produced according to these methods may have a single layer content exceeding 95%. Field effect transistors fabricated by the inventive process have room temperature hole mobilities that are a factor of 2-5 larger than those measured for samples grown on commercially-available copper foil substrates.
    Type: Application
    Filed: August 11, 2011
    Publication date: August 22, 2013
    Applicant: The Trustees Of The University Of Pennsylvania
    Inventors: Alan T. Johnson, Zhengtang Luo
  • Publication number: 20130164859
    Abstract: The present invention provides a broad response single-stranded DNA-graphene chemical sensor device. The present invention also provides methods for improving the ability of graphene to work as a chemical sensor by using single-stranded DNA as a sensitizing agent.
    Type: Application
    Filed: March 30, 2011
    Publication date: June 27, 2013
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: Alan T. Johnson, Ye Lu, Brett R. Goldsmith, Nicholas John Kybert
  • Patent number: 8242174
    Abstract: Compounds having the formula wherein the symbols have the meaning described in the specification are hydroxamic acid derivatives of aniline and capable of inhibiting the lethal effects of infection by anthrax bacteria and are useful in the treatment of poisoning by anthrax.
    Type: Grant
    Filed: January 30, 2008
    Date of Patent: August 14, 2012
    Assignee: PanThera Biopharma LLC
    Inventors: Alan T. Johnson, Guan-Sheng Jiao
  • Publication number: 20120157462
    Abstract: Compounds having the formula wherein the symbols have the meaning described in the specification are hydroxamic acid derivatives of aniline and capable of inhibiting the lethal effects of infection by anthrax bacteria and are useful in the treatment of poisoning by anthrax.
    Type: Application
    Filed: January 30, 2008
    Publication date: June 21, 2012
    Inventors: Alan T. Johnson, Guan-Sheng Jiao
  • Publication number: 20120107593
    Abstract: Disclosed are graphene oxide membrane materials of high surface area, which membranes suitably have a surface area of above about 200 ?m and exhibit electrical conductivity in excess of about 200 S/m. Also provided are methods of synthesizing such membranes, as well as devices and sensors that incorporate these novel grapheme materials.
    Type: Application
    Filed: December 4, 2009
    Publication date: May 3, 2012
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: Zhengtang Luo, Alan T. Johnson
  • Patent number: 8119692
    Abstract: Compounds having the formula wherein the symbols have the meaning described in the specification are hydroxamic acid derivatives of 4-phenyl-4-hydroxy-butyric acid and capable of inhibiting the lethal effects of infection by anthrax bacteria and are useful in the treatment of poisoning by anthrax.
    Type: Grant
    Filed: March 28, 2008
    Date of Patent: February 21, 2012
    Assignee: PanThera Biopharma LLC
    Inventors: Alan T. Johnson, Seongjin Kim