Abstract: The present invention provides methods of gene therapy to prevent or treat exposure to organophosphate (OP) toxins, such as that observed in Gulf War Syndrome patients. In particular, vectors comprising the PON1 gene, which express the enzyme paraoxonase, can be used to prevent damage from OP toxins when given prior to exposure, or to reduce the toxic effects after exposure. Depending on the PON1 isotype (R or Q), protection against particular toxins may be achieved.

Abstract: The invention concerns a golf club which finds use particularly as training device. For the purpose of the adaptation of the device to the individual needs of the player, for example in respect of build-up or improvement in the condition, the shaft of the device is at least partially filled with a flowable filling material which, with the effect of the redisposition of the center of gravity while the total weight remains constant, can be redisposed in desired partial quantity into the hollow space of the striker head by way of an openable closure arranged in the region of that end of the shaft, which faces the striker head.