Abstract: A process is provided for the preparation of albumin from a yeast culture medium which has extremely low levels of or is essentially free of colorants, metal ions, human proteins, host proteins, fragments of albumin, polymers or aggregates of albumin and viruses, and which is essentially non-glycated, relatively high in free thiol and with an intact C-terminus. The process comprises separating the yeast from the culture medium to yield an albumin solution; subjecting the albumin solution to positive mode cation exchange, affinity, and positive mode anion exchange chromatography; and concentrating and formulating the albumin with sodium octanoate and sodium chloride.

Abstract: A method, and the resultant apparatus, for designing a fire resistant structural beam, such as a computer-aided design of a fabricated steel beam having an intumescent coating material, by obtaining a number of values for a number of physical parameters of the structural beam, including reading temperature information that comprise empirical information derived from heating a structural beam and a number of temperatures at a number of locations.

Abstract: The present invention provides a method of treatment or prophylaxis of hepatitis B virus in a subject comprising administering an effective amount of a compound of formula (1) or a pharmaceutically acceptable derivative, salt or prodrug thereof. In addition, there is provided compounds of formula (1) and pharmaceutical compositions thereof. Further, methods of preparing compounds of formula (1) are disclosed.

Abstract: A system, apparatus and method for providing phase lock conditions detection such as a quality of phase lock and loss of lock detection. A phase locked loop (PLL) circuit may comprise an oscillator for providing an output frequency, as well as a detector for detecting the output frequency of the oscillator, comparing the output frequency with a reference signal and outputting a first and second signals as a function of the comparison. The PLL circuit may further include an amplifying circuit for receiving the first and second signals, monitoring a deviation of the first and second signals from a predetermined threshold, and generating a third signal as a function of the deviation. The PLL circuit may further comprise a comparison circuit for receiving the third signal, comparing the third signal to a window threshold, and generating a fourth signal as a function of the comparison.

Abstract: The present invention provides a compound of formula (I), (II), (III) and (IV) as defined herein and pharmaceutically acceptable derivatives thereof. The present invention further provides use of the compounds of the present invention in the treatment of bacterial infection and in the treatment of HIV infection. Also provided are pharmaceutical compositions comprising the compounds of the present invention.

Abstract: A process is provided for the preparation of albumin which has extremely low levels of or is essentially free of colorants, metal ions, human proteins, host proteins, fragments of albumin, polymers or aggregates of albumin and viruses, and which is essentially non-glycated, relatively high in free thiol and with an intact C-terminus. The process comprises passing albumin (preferably expressed and secreted by transformed yeast) through positive mode cation exchange and then positive mode anion exchange chromatography. Other steps may also be employed, ultrafiltration, gel permeation chromatography, affinity chromatography binding the albumin by using blue dyes) and affinity chromatography binding contaminants by using an aminophenylboronic acid resin. Elution of albumin, with a compound having affinity for albumin, from a material having no specific affinity for albumin is also disclosed, as is removal of ammonium ions with a counter-ion.

Abstract: A storage-stable high-strength aqueous glyphosate concentrate, preferably containing greater than 400 g/l glyphosate expressed as acid, comprises the potassium salt of glyphosate, an alkylglycoside surfactant and an alkoxylated alkylamine surfactant at a preferred total concentration of alkylglycoside and alkoxylated alkylamine from about 160 to 300 g/l and at a preferred ratio of alkylglycoside to alkoxylated alkylamine of from about 1 part by weight of alkylglycoside per 1 part by weight of alkoxylated alkylamine to about 5 parts by weight of alkylglycoside per 1 part by weight of alkoxylated alkylamine

Abstract: The present invention relates to a process for purifying the protein human serum albumin extracted from serum or recombinant human albumin produced by transforming a microorganism with a nucleotide coding sequence encoding the amino acid sequence of human serum albumin. The present invention provides highly purified albumin.

Abstract: A process is provided for the preparation of albumin which has extremely low levels of or is essentially free of colorants, metal ions, human proteins, host proteins, fragments of albumin, polymers or aggregates of albumin and viruses, and which is essentially non-glycated, relatively high in free thiol and with an intact C-terminus. The process comprises passing albumin (preferably expressed and secreted by transformed yeast) through positive mode cation exchange and then positive mode anion exchange chromatography. Other steps may also be employed, for example ultrafiltration, gel permeation chromatography, affinity chromatography binding the albumin (for example using blue dyes) and affinity chromatography binding contaminants (for example using an aminophenylboronic acid resin). Elution of albumin, with a compound having affinity for albumin, from a material having no specific affinity for albumin is also disclosed, as is removal of ammonium ions with a counter-ion.

Abstract: Methods and apparatus for depositing roadway material using a road paving machine having a hopper for storing the roadway material, a feed conveyor for transferring the roadway material from the hopper to an auger, and a screed for levelling the roadway material. A trough prevents the roadway material from falling from the feed conveyor onto a road surface. The trough diverts and deposits the roadway material to one side of the paving machine.

Abstract: A storage-stable high-strength aqueous glyphosate concentrate, preferably containing greater than 400 g/l glyphosate expressed as acid, comprises the potassium salt of glyphosate, an alkylglycoside surfactant and an alkoxylated alkylamine surfactant at a preferred total concentration of alkylglycoside and alkoxylated alkylamine from about 160 to 300 g/l and at a preferred ratio of alkylglycoside to alkoxylated alkylamine of from about 1 part by weight of alkylglycoside per 1 part by weight of alkoxylated alkylamine to about 5 parts by weight of alkylglycoside per 1 part by weight of alkoxylated alkylamine

Abstract: A storage-stable high-strength aqueous glyphosate concentrate, preferably containing greater than 400 g/l glyphosate expressed as acid, comprises the potassium salt of glyphosate, an alkylglycoside surfactant and an alkoxylated alkylamine surfactant at a preferred total concentration of alkylglycoside and alkoxylated alkylamine from about 160 to 300 g/l and at a preferred ratio of alkylglycoside to alkoxylated alkylamine of from about 1 part by weight of alkylglycoside per 1 part by weight of alkoxylated alkyl amine to about 5 parts by weight of alkylglycoside per 1 part by weight of alkoxylated alkylamine.

Abstract: An electrostatic chuck 12 for a plasma reactor apparatus 10 comprises a base metallic section 23, a pair of electrodes 24 set in bonding material 27 and electrically insulated from the base by a plate 29 and a thick dielectric layer 20 (e.g. 0.5 to 1.5 mm), which covers the electrodes 24 and bonding material 27 and forms the support surfaces for wafers 31.

Abstract: Method and apparatus for depositing roadway material on a road bed using a road paving machine having a spreader for laterally spreading the material and a screed for leveling the material. A guide underneath the spreader and the screed is used to control the height of the screed above the road bed. The guide also confines the width of the material deposited by the road paving machine to less than the width of the screed which is normally the standard width of material deposited by the road paving machine.

Abstract: Used single use camera bodies (10) and miscellaneous loose parts (130, 132, 134) are dumped into a receiver conveyor (72) from which they move to a metering conveyor (88) which delivers them to a series of vibratory grid separators (106, 108, 110) having grid bars (124) separated by slots (126) configured such that each camera body can be positioned with at least one lengthwise corner (148-154) located in the slot and the center of gravity (156) of the camera body positioned above the slot. Camera bodies are thus conveyed lengthwise along the vibratory grid separators to enable loose parts to fall more readily through the slots. Camera bodies are then separated by types at a plurality of sorting stations (186).

Abstract: Reduction (preferably elimination) of the HSP150 protein in a yeast used to produce desired foreign proteins, especially human albumin, facilitates purification of the protein.