Abstract: Patients diagnosed with a cancer harboring an IDH-1 mutation can be treated by the administration of a therapeutically effective amount of a pharmaceutical composition comprising Compound 1, a selective inhibitor of 2-HG production from mIDH-1 enzymes including the R132 mutations R132C, R132H, R132L, R132G, and R132S.

Abstract: A process to cure and/or modify the surface of a three dimensional (3D) printed part comprising the steps of immersing a three dimensional (3D) printed part, containing reactive moieties, into a liquid bath at an elevated temperature to effect polymerization of the reactive moieties of the 3D printed part to provide a cured 3D printed part is described. The liquid bath can further contain reactive molecules that can react with the surface of the 3D printed part to provide a coating which alters the surface characteristics of the 3D printed part.

Abstract: Disclosed herein is a massively parallel patterning tool for the deposition of single metals or metal alloys with size and composition control. Methods of the disclosure use a hydrogel array of pyramidal pen tips as a medium for localized electrodeposition, in conjunction with a scanning probe lithography platform and a three-electrode cell. This versatile technique can be used for high-throughput 3D printing, biomolecule patterning, or screening of catalyst nanoparticles or thin films.

Abstract: An implantable tissue repair device containing a body having a biocompatible hydrogel and a plurality of tissue anchoring elements projecting from the body, where the anchoring elements are integrally formed with the body and have the same biocompatible hydrogel as the body, and the anchoring elements, in use, are arranged to enter apertures in a tissue and anchor the device to the tissue.

Abstract: A process to cure and/or modify the surface of a three dimensional (3D) printed part comprising the steps of immersing a three dimensional (3D) printed part, containing reactive moieties, into a liquid bath at an elevated temperature to effect polymerization of the reactive moieties of the 3D printed part to provide a cured 3D printed part is described. The liquid bath can further contain reactive molecules that can react with the surface of the 3D printed part to provide a coating which alters the surface characteristics of the 3D printed part.

Abstract: A process to cure and/or modify the surface of a three dimensional (3D) printed part comprising the steps of immersing a three dimensional (3D) printed part, containing reactive moieties, into a liquid bath at an elevated temperature to effect polymerization of the reactive moieties of the 3D printed part to provide a cured 3D printed part is described. The liquid bath can further contain reactive molecules that can react with the surface of the 3D printed part to provide a coating which alters the surface characteristics of the 3D printed part.

Abstract: A process to cure and/or modify the surface of a three dimensional (3D) printed part comprising the steps of immersing a three dimensional (3D) printed part, containing reactive moieties, into a liquid bath at an elevated temperature to effect polymerization of the reactive moieties of the 3D printed part to provide a cured 3D printed part is described. The liquid bath can further contain reactive molecules that can react with the surface of the 3D printed part to provide a coating which alters the surface characteristics of the 3D printed part.

Abstract: An implantable tissue repair device for the repair, replacement or augmentation of a tissue, the device having a biocompatible solvated structural material, where at least part of the structural material is in a compressed and/or dried state.

Abstract: An implantable tissue repair device containing a body having a biocompatible hydrogel and a plurality of tissue anchoring elements projecting from the body, where the anchoring elements are integrally formed with the body and have the same biocompatible hydrogel as the body, and the anchoring elements, in use, are arranged to enter apertures in a tissue and anchor the device to the tissue.

Abstract: An implantable tissue repair device containing a body having a biocompatible hydrogel and a rigid support at least partly located within the body or device, or connected to the body or device.

Abstract: An embedded security system for an environment-controlled trailer including a transportation refrigeration unit. The security system includes a plurality of sensors mounted to the trailer and a communication device embedded in the transportation refrigeration unit of the trailer, the communication device being configured to receive data from the plurality of sensors, and to send the received data to a controller being remote from the trailer. The controller is configured to monitor the security status of the trailer and to determine a security risk at the trailer based, at least in part, on the received data.

Abstract: A smart mobile device charger comprises a communication unit configured to communicate with at least one first device. The communication unit is further configured to receive a first charge authorization signal from a mobile application associated with each of the at least one first device. A charging unit is coupled to the communication unit the and the charging unit is configured to charge at least one first mobile device based at least in part on the first charge authorization signal. Also disclosed are a method and system of smart charging mobile devices.

Abstract: An embedded security system for an environment-controlled trailer including a transportation refrigeration unit. The security system includes a plurality of sensors mounted to the trailer and a communication device embedded in the transportation refrigeration unit of the trailer, the communication device being configured to receive data from the plurality of sensors, and to send the received data to a controller being remote from the trailer. The controller is configured to monitor the security status of the trailer and to determine a security risk at the trailer based, at least in part, on the received data.

Abstract: An embedded security system for an environment-controlled trailer including a transportation refrigeration unit. The security system includes a plurality of sensors mounted to the trailer and a communication device embedded in the transportation refrigeration unit of the trailer, the communication device being configured to receive data from the plurality of sensors, and to send the received data to a controller being remote from the trailer. The controller is configured to monitor the security status of the trailer and to determine a security risk at the trailer based, at least in part, on the received data.

Abstract: A seatbelt buckle retaining device comprising a clamp device for attachment to a magnetic device arranged to retain a seatbelt buckle when in use, wherein the clamp device is arranged to: i) capture the magnetic device when in use and only release the magnetic device upon activation of a clasp device, and ii) locate under a car seat cover, or be permanently affixed within a car seat or car seat cover.

Abstract: An embedded security system for an environment-controlled trailer including a transportation refrigeration unit. The security system includes a plurality of sensors mounted to the trailer and a communication device embedded in the transportation refrigeration unit of the trailer, the communication device being configured to receive data from the plurality of sensors, and to send the received data to a controller being remote from the trailer. The controller is configured to monitor the security status of the trailer and to determine a security risk at the trailer based, at least in part, on the received data.

Abstract: A micro-hybrid motor vehicle 2 having an engine 5 started by an electrical starter 6 is disclosed having a starter system that adaptively responds to ageing of an electrical power source such as a capacitor 12 used to power the starter motor 6 so as to maintain engine starting performance. The starter system includes a controller 20 which is programmed to increase the voltage used to charge the capacitor 12 when it is determined that the state of health of the capacitor 12 has degraded.

Abstract: A system for managing prescription data is provided. The system for managing prescription data includes a switch system. The switch system is configured to receive prescription submissions from pharmacy systems, submit the prescription submissions to approval systems, receive responses from the approval systems, and transmit the responses to the pharmacy systems. The switch system is further configured to receive treatment classification data including pathogen groups and pharmaceuticals prescribed to treat symptoms occurring from exposure to each pathogen group. The switch system is further configured to determine normal variations of the prescription submissions, detect anomalous variations of the prescription submissions, and generate a notification in response to detecting an anomalous variation.

Abstract: A blade for the use in the generation of power has a leading edge and a trailing edge. A first shell portion of the blade extends from the leading edge to the trailing edge. A second shell portion of the blade also extends from the leading edge to the trailing edge. A root portion of the blade is positioned proximate the wind turbine and a tip portion which extends from the root portion away from the wind turbine. A trailing edge insert is positioned between the first shell portion and the second shell portion proximate the root portion. The trailing edge insert has a surface which extends between and separates the first shell portion from the second shell portion at the trailing edge, such that the insert provides a high lift profile for increased blade efficiency.