Patents by Inventor Alan Widgerow
Alan Widgerow has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220097050Abstract: Provided herein are devices and methods of processing a sample that include, in several embodiments, rotating one or more microfluidic chips that are mounted on a support plate using a motor driven rotational chuck. By spinning one or more of the microfluidic chips about a common center of rotation in a controlled manner, high flow rates (and high shear forces) are imparted to the sample in a controlled manner. Each microfluidic chip can be rotated 180° on the support plate so that the sample can be run back-and-forth through the microfluidic devices. Because the support plate can be driven at relatively high RPMs, high flow rates are generated within the microfluidic chips. This increases the shear forces on the sample and also decreases the processing time involved as the sample can quickly pass through the shear-inducing features of the microfluidic chip(s).Type: ApplicationFiled: August 26, 2021Publication date: March 31, 2022Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Ahmed Zobi, Justin Stovner, Hugo Salas, David Duarte, Jered Haun, Alan Widgerow, Derek Banyard
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Patent number: 11130127Abstract: Provided herein are devices and methods of processing a sample that include, in several embodiments, rotating one or more microfluidic chips that are mounted on a support plate using a motor driven rotational chuck. By spinning one or more of the microfluidic chips about a common center of rotation in a controlled manner, high flow rates (and high shear forces) are imparted to the sample in a controlled manner. Each microfluidic chip can be rotated 180° on the support plate so that the sample can be run back-and-forth through the microfluidic devices. Because the support plate can be driven at relatively high RPMs, high flow rates are generated within the microfluidic chips. This increases the shear forces on the sample and also decreases the processing time involved as the sample can quickly pass through the shear-inducing features of the microfluidic chip(s).Type: GrantFiled: January 30, 2020Date of Patent: September 28, 2021Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Ahmed Zobi, Justin Stovner, Hugo Salas, David Duarte, Jered Haun, Alan Widgerow, Derek Banyard
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Patent number: 10722540Abstract: A method of processing a lipoaspirate sample includes mechanically processing the lipoaspirate sample to generate nanofat. The nanofat is then input into a microfluidic device comprising a plurality of serially arranged stages comprising one or more microfluidic channels having a plurality of expansion and constriction regions extending along the length of the one or more microfluidic channels, wherein each subsequent stage of the plurality has an increasing number of microfluidic channels of decreasing dimensions. The nanofat is flowed through the plurality of serially arranged stages in a plurality of cycles to generate sheared nanofat. The sheared nanofat is then collected after flowing through the plurality of serially arranged stages. The sheared nanofat may then be injected and/or applied to the subject. In an alternative embodiment, filtered or mechanically processed lipoaspirate may be run through the microfluidic device.Type: GrantFiled: January 31, 2017Date of Patent: July 28, 2020Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Jered Haun, Alan Widgerow, Derek Banyard, Xiaolong Qiu
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Publication number: 20200164374Abstract: Provided herein are devices and methods of processing a sample that include, in several embodiments, rotating one or more microfluidic chips that are mounted on a support plate using a motor driven rotational chuck. By spinning one or more of the microfluidic chips about a common center of rotation in a controlled manner, high flow rates (and high shear forces) are imparted to the sample in a controlled manner. Each microfluidic chip can be rotated 180° on the support plate so that the sample can be run back-and-forth through the microfluidic devices. Because the support plate can be driven at relatively high RPMs, high flow rates are generated within the microfluidic chips. This increases the shear forces on the sample and also decreases the processing time involved as the sample can quickly pass through the shear-inducing features of the microfluidic chip(s).Type: ApplicationFiled: January 30, 2020Publication date: May 28, 2020Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Ahmed Zobi, Justin Stovner, Hugo Salas, David Duarte, Jered Haun, Alan Widgerow, Derek Banyard
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Patent number: 10589268Abstract: Provided herein are devices and methods of processing a sample that include, in several embodiments, rotating one or more microfluidic chips that are mounted on a support plate using a motor driven rotational chuck. By spinning one or more of the microfluidic chips about a common center of rotation in a controlled manner, high flow rates (and high shear forces) are imparted to the sample in a controlled manner. Each microfluidic chip can be rotated 180° on the support plate so that the sample can be run back-and-forth through the microfluidic devices. Because the support plate can be driven at relatively high RPMs, high flow rates are generated within the microfluidic chips. This increases the shear forces on the sample and also decreases the processing time involved as the sample can quickly pass through the shear-inducing features of the microfluidic chip(s).Type: GrantFiled: August 10, 2018Date of Patent: March 17, 2020Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Ahmed Zobi, Justin Stovner, Hugo Salas, David Duarte, Jered Haun, Alan Widgerow, Derek Banyard
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Publication number: 20180361382Abstract: Provided herein are devices and methods of processing a sample that include, in several embodiments, rotating one or more microfluidic chips that are mounted on a support plate using a motor driven rotational chuck. By spinning one or more of the microfluidic chips about a common center of rotation in a controlled manner, high flow rates (and high shear forces) are imparted to the sample in a controlled manner. Each microfluidic chip can be rotated 180° on the support plate so that the sample can be run back-and-forth through the microfluidic devices. Because the support plate can be driven at relatively high RPMs, high flow rates are generated within the microfluidic chips. This increases the shear forces on the sample and also decreases the processing time involved as the sample can quickly pass through the shear-inducing features of the microfluidic chip(s).Type: ApplicationFiled: August 10, 2018Publication date: December 20, 2018Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Ahmed Zobi, Justin Stovner, Hugo Salas, David Duarte, Jered Haun, Alan Widgerow, Derek Banyard
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Publication number: 20080051822Abstract: A method of stretching the skin of a patient such as a patient who has undergone a mastectomy is described. A surgeon implants an expander under the skin of the patient and inserts a small amount of liquid to enlarge the expander. Thereafter the patient herself operates a patient controlled liquid delivery machine (“PCD”) to deliver amounts of the liquid to the expander. The PCD is arranged so that only small amounts of liquid can be introduced at each actuation thereof and that there is a delay between the times that the PCD can be actuated. Thus the expander can be increased in size in small increments which will not cause the patient pain until the expander has reached the desired size.Type: ApplicationFiled: July 24, 2007Publication date: February 28, 2008Inventor: Alan Widgerow
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Publication number: 20060161196Abstract: Equipment and methods for preparing a person for placement of a subcutaneous prosthesis, e.g., are disclosed. An inflatable expander, such as an expandable bladder, is introduced under an area of skin to be stretched. A tube extends through the skin to a preferably valved fluid flow connector. The person whose skin is to be stretched can periodically introduce desired amounts of fluid, such as saline solution, into the expander by use of a patient controlled delivery machine (“PCD machine”) which is connectible to the fluid flow connector. The PCD machine can be a syringe having an outlet fitting which is matable to the flow connector. Since the person controls the times and amounts of liquid added to the expander, there is a reduction in the time, cost, and discomfort encountered by the person in preparation for placement of a prosthesis under stretched area of skin.Type: ApplicationFiled: January 17, 2006Publication date: July 20, 2006Inventor: Alan Widgerow