Abstract: Overvoltage protection circuits include a combination of an overvoltage detection circuit and a voltage clamping circuit that inhibits sustained overvoltage conditions. An overvoltage detection circuit can include first and second terminals electrically coupled to first and second power supply signal lines, respectively. This overvoltage detection circuit may be configured to generate a clamp activation signal (CAS) in response to detecting an excessive overvoltage between the first and second power supply signal lines. This CAS is provided to an input of the voltage clamping circuit, which is electrically coupled to the first power supply signal line and configured to sink current from the first power supply signal line in response to the CAS. The voltage clamping circuit may be configured to turn on and sink current from the first power supply signal line in-sync with a transition of the CAS from a first logic state to a second logic state.