Patents by Inventor Alan Xi Huang

Alan Xi Huang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CCR4 antagonists
    Patent number: 7144903
    Abstract: Compounds, compositions and methods are provided that are useful in the treatment of chemokine receptor-mediated conditions and diseases. In particular, the invention provides compounds which modulate CCR4 function or a CCR4-mediated response. The subject compounds and compositions are useful for the treatment or prevention of inflammatory conditions and diseases.
    Type: Grant
    Filed: May 22, 2002
    Date of Patent: December 5, 2006
    Assignee: Amgen Inc.
    Inventors: Tassie Collins, Hossen Mahmud, Jonathan Houze, Alan Xi Huang, Julio C. Medina, Xuemei Wang, Feng Xu, Qingge Xu, Liusheng Zhu
  • CXCR3 antagonists
    Patent number: 7067662
    Abstract: Compounds, compositions and methods that are useful in the treatment of inflammatory and immune conditions and diseases are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of a chemokine receptor. The subject methods are useful for the treatment of inflammatory and immunoregulatory disorders and diseases, such as multiple sclerosis, rheumatoid arthritis and type I diabetes.
    Type: Grant
    Filed: September 21, 2004
    Date of Patent: June 27, 2006
    Assignee: Amgen SF, LLC
    Inventors: Julio C. Medina, Michael G. Johnson, An-Rong Li, Jiwen Liu, Alan Xi Huang, Liusheng Zhu, Andrew P. Marcus
  • Substituted Quinazolin-4(3H)-one compounds, compositions, and methods for their use
    Patent number: 7053215
    Abstract: Compounds are provided that have the formula: where X, A4, Ra, R1, R2, R3, R4, R14, L and Q are as described herein. These compounds are useful, for example, as modulators of a chemokine receptor and for treatment of inflammatory and immunoregulatory disorders and diseases. Pharmaceutical compositions and methods of using these compounds for the treatment of inflammatory and immunoregulatory disorders and diseases, such as multiple sclerosis, rheumatoid arthritis and type I diabetes, are also provided.
    Type: Grant
    Filed: August 29, 2002
    Date of Patent: May 30, 2006
    Assignee: Amgen SF, LLC
    Inventors: Julio C. Medina, Michael G. Johnson, An-Rong Li, Jiwen Liu, Alan Xi Huang, Liusheng Zhu, Andrew P. Marcus
  • Substituted pyrido[2,3-d]pyrimidines and methods for their use
    Patent number: 6964967
    Abstract: Compounds having the formula: wherein A4 is N and X is —C(O)— or —CH2—, are provided, which are useful as modulators of a chemokine receptor and for treatment of inflammatory and immunoregulatory disorders and diseases. Pharmaceutical compositions and methods of using these compounds for the treatment of inflammatory and immunoregulatory disorders and diseases, such as multiple sclerosis, rheumatoid arthritis and type I diabetes, are also provided.
    Type: Grant
    Filed: December 11, 2001
    Date of Patent: November 15, 2005
    Assignee: Amgen, Inc.
    Inventors: Alan Xi Huang, Michael G. Johnson, An-Rong Li, Jiwen Liu, Julio C. Medina
  • Asthma and allergic inflammation modulators
    Publication number: 20040220237
    Abstract: Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of inflammatory and immune-related diseases and conditions. In particular, the invention provides compounds which modulate the function and/or expression of proteins involved in atopic diseases, inflammatory conditions and cancer. The subject compounds are carboxylic acid derivatives.
    Type: Application
    Filed: December 19, 2003
    Publication date: November 4, 2004
    Inventors: Zice Fu, Alan Xi Huang, Jiwen Liu, Julio C. Medina, Michael J. Schmitt, H. Lucy Tang, Yingcai Wang, Qingge Xu
  • CXCR3 antagonists
    Publication number: 20030069234
    Abstract: Compounds, compositions and methods that are useful in the treatment of inflammatory and immune conditions and diseases are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of a chemokine receptor. The subject methods are useful for the treatment of inflammatory and immunoregulatory disorders and diseases, such as multiple sclerosis, rheumatoid arthritis and type I diabetes.
    Type: Application
    Filed: June 6, 2002
    Publication date: April 10, 2003
    Inventors: Julio C. Medina, Michael G. Johnson, An-Rong Li, Jiwen Liu, Alan Xi Huang, Liusheng Zhu, Andrew P. Marcus
  • CXCR3 antagonists
    Publication number: 20030055054
    Abstract: Compounds, compositions and methods that are useful in the treatment of inflammatory and immune conditions and diseases are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of a chemokine receptor. The subject methods are useful for the treatment of inflammatory and immunoregulatory disorders and diseases, such as multiple sclerosis, rheumatoid arthritis and type I diabetes.
    Type: Application
    Filed: August 29, 2002
    Publication date: March 20, 2003
    Applicant: Tularik, Inc.
    Inventors: Julio C. Medina, Michael G. Johnson, An-Rong Li, Jiwen Liu, Alan Xi Huang, Liusheng Zhu, Andrew P. Marcus
  • Ccr4 antagonists
    Publication number: 20030018022
    Abstract: Compounds, compositions and methods are provided that are useful in the treatment of chemokine receptor-mediated conditions and diseases. In particular, the invention provides compounds which modulate CCR4 function or a CCR4-mediated response. The subject compounds and compositions are useful for the treatment or prevention of inflammatory conditions and diseases.
    Type: Application
    Filed: May 22, 2002
    Publication date: January 23, 2003
    Applicant: Tularik Inc.
    Inventors: Tassie Collins, Hossen Mahmud, Jonathan Houze, Alan Xi Huang, Julio C. Medina, Xuemei Wang, Feng Xu, Qingge Xu, Liusheng Zhu
  • CXCR3 antagonists
    Publication number: 20020169159
    Abstract: Compounds, compositions and methods that are useful in the treatment of inflammatory and immune conditions and diseases are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of a chemokine receptor. The subject methods are useful for the treatment of inflammatory and immunoregulatory disorders and diseases, such as multiple sclerosis, rheumatoid arthritis and type I diabetes.
    Type: Application
    Filed: December 11, 2001
    Publication date: November 14, 2002
    Applicant: Tularik Inc.
    Inventors: Julio C. Medina, Michael G. Johnson, An-Rong Li, Jiwen Liu, Alan Xi Huang, Liusheng Zhu, Andrew P. Marcus