Abstract: An artificial retina device to electrically stimulate a neuroretina of an eye to produce artificial vision, the artificial retina device comprising: an electrical source; at least one stimulating electrode connected with the electrical source; and at least one ground return electrode connected with the electrical source, wherein the stimulating electrode and ground return electrode are configured to be disposed within the eye on opposite sides of the neuroretina.

Abstract: An artificial retina device to electrically stimulate a neuroretina of an eye to produce artificial vision, the artificial retina device comprising: an electrical source; at least one stimulating electrode connected with the electrical source; and at least one ground return electrode connected with the electrical source, wherein the stimulating electrode and ground return electrode are configured to be disposed within the eye on opposite sides of the neuroretina.

Abstract: Mechanically activated objects or devices for use in treating degenerative retinal diseases are provided. Such devices apply mechanical forces to tissues of an eye to effectuate treatment and are configured for chronic implantation (thereby applying chronic stimulation/irritation) in or on the eye. The devices may be configured for contact with a retina of the eye, preferably positioned in a subretinal space. Various embodiments comprise a moving member configured for chronic contact with at least a portion of the eye, which moving member is activated by an actuator. In some embodiments, the actuator may be distally located relative to the moving member. Alternatively, the moving member may be supported by a body member that, optionally, also supports the actuator.

Abstract: An artificial retinal device, implanted in the subretinal space of the eye in persons with certain types of retinal blindness, induces artificial vision by electrical stimulation of the remaining viable cells of the retina. The artificial retina device includes a stimulating electrode unit preferably placed in the subretinal space.

Abstract: Mechanically activated objects or devices for use in treating degenerative retinal diseases are provided. Such devices apply mechanical forces to tissues of an eye to effectuate treatment and are configured for chronic implantation (thereby applying chronic stimulation/irritation) in or on the eye. The devices may be configured for contact with a retina of the eye, preferably positioned in a subretinal space. Various embodiments comprise a moving member configured for chronic contact with at least a portion of the eye, which moving member is activated by an actuator. In some embodiments, the actuator may be distally located relative to the moving member. Alternatively, the moving member may be supported by a body member that, optionally, also supports the actuator.

Abstract: An artificial retina device and a retinal stimulation system and method for stimulating and modulating its function is disclosed. The artificial retina device includes multi-phasic microphotodiode subunits. In persons suffering from blindness due to outer retinal layer damage, a plurality of such devices, when surgically implanted into the subretinal space, may allow useful formed artificial vision to develop. By projecting real or computer controlled visible light images, and computer controlled infrared light images or illumination, simultaneously or in rapid alternation onto the artificial retina device, the nature of induced retinal images may be modulated and improved. The retinal stimulation system may be worn as a headset. Color images may be induced by programming the stimulating pulse durations and frequencies of the stimulation.

Abstract: Methods of using electrical stimulation by itself or in conjunction with growth factors to treat and prevent visual loss due to choroidal, retinal pigment epithelial and/or neuroretinal cell degeneration and dysfunction are presented.

Abstract: A visible and infrared light powered retinal implant is disclosed that is implanted into the subretinal space for electrically inducing formed vision in the eye. The retinal implant includes a stacked microphotodetector arrangement having an image sensing pixel layer and a voltage and current gain adjustment layer for providing variable voltage and current gain to the implant so as to obtain better low light implant performance than the prior art, and to compensate for high retinal stimulation thresholds present in some retinal diseases.

Abstract: An artificial retinal device, implanted in the subretinal space of the eye in persons with certain types of retinal blindness, induces artificial vision by electrical stimulation of the remaining viable cells of the retina. The artificial retina device includes a stimulating electrode unit preferably placed in the subretinal space, and a tail-like extension housing a distant electrical return ground electrode unit that may be placed in the vitreous cavity. The stimulating electrode unit includes an array of electrode subunits. Each electrode subunit includes one or more microphotodiodes electrically connected, for example, in series to provide increased voltage and current to its microelectrode. The stimulating electrode unit and the ground return electrode of the ground return electrode unit are preferably disposed on opposite sides of the neuroretina to allow for efficient and high resolution transretinal electrical stimulation of the neuroretinal cells.

Abstract: A system and method are disclosed for carrying additional information data on multiplexed signals which are modulated on different wavelengths. An information code such as an address or control data for a particular data signal at a selected wavelength is overlaid on the parallel multiplexed signals. The information code may be overlaid by attenuation or changing the amplitude of the different signals. A separate marker channel at a separate wavelength is also multiplexed with the data signals to indicate the presence of an information code. An optical data detector array is used to optically determine the encoded address by comparing the signals with light levels and producing an output when a matching code is detected. The optical data detector array uses a series of detectors each corresponding to the wavelength of light signals carrying the information data.

Abstract: A system and method are disclosed for carrying additional information data on multiplexed signals which are modulated on different wavelengths. An information code such as an address or control data for a particular data signal at a selected wavelength is overlaid on the parallel multiplexed signals. The information code may be overlaid by attenuation or changing the amplitude of the different signals. A separate marker channel at a separate wavelength is also multiplexed with the data signals to indicate the presence of an information code. An optical data detector array is used to optically determine the encoded address by comparing the signals with light levels and producing an output when a matching code is detected. The optical data detector array uses a series of detectors each corresponding to the wavelength of light signals carrying the information data.

Abstract: To provide indirect electrical stimulation for treatment of degenerative retinal diseases, such stimulation is applied to surface structures of the eye. A source of an electrical stimulation signal is coupled to at least one stimulating electrode configured for chronic contact with a surface structure of an eyeball. Additionally, at least one return electrode, which may be configured either for contact with conductive biological tissue distant from the eyeball or for contact with a surface structure of the eyeball, is also coupled to the source. The source of the electrical stimulation signal may be implemented internal to a body of a patient, external to the body or through a combined internal/external approach. The active and return electrodes are preferably arranged such that the circuit created by the source, stimulating electrode, biological tissue and return electrode provides trans-retinal electrical stimulation to thereby effect treatment.

Abstract: An artificial retina device and a method for stimulating and modulating its function is disclosed. The artificial retina device is comprised of plural multi-phasic microphotodiode subunits. In persons suffering from blindness due to outer retinal layer damage, a plurality of such devices, when surgically implanted into the subretinal space, may allow useful formed artificial vision to develop. One device, called a MMRI-4, transduces light into electric currents to stimulate the retina. The four microphotodiode subunits of the MMRI-4 are oriented so that each flattened sides of the MMRI-4 has two subunits in a PiN configuration and two subunits in a NiP configuration. The flattened cubic shape of the MMRI-4 will allow one or the other of the two flattened sides to be preferentially directed toward incident light when implanted in the subretinal space.

Abstract: A visible and infrared light powered retinal implant is disclosed that is implanted into the subretinal space for electrically inducing formed vision in the eye. The retinal implant includes a stacked microphotodetector arrangement having an image sensing pixel layer and a voltage and current gain adjustment layer for providing variable voltage and current gain to the implant so as to obtain better low light implant performance than the prior art, and to compensate for high retinal stimulation thresholds present in some retinal diseases.

Abstract: An instrument is disclosed for use with implants, particularly for use in implanting retinal implants into the sub-retinal space of an eye. The instrument includes a handpiece and an inserter attachment. The handpiece includes a first sliding member movably disposed within a longitudinal channel of the handpiece and comprising finger portions adapted to couple and retain the inserter attachment to the handpiece. A nose member of the handpiece includes at least two recesses for mating with a locating pin in the inserter attachment for maintaining alignment of the inserter attachment. The inserter attachment includes a pusher cap that is biased to retain a pusher in a retracted position. Also, an inserter tip of the inserter attachment includes a cover that defines a space for and helps retain the implant within the inserter attachment.

Abstract: A system and method are disclosed for carrying additional information data on multiplexed signals which are modulated on different wavelengths. An information code such as an address or control data for a particular data signal at a selected wavelength is overlaid on the parallel multiplexed signals. The information code may be overlaid by attenuation or changing the amplitude of the different signals. A separate marker channel at a separate wavelength is also multiplexed with the data signals to indicate the presence of an information code. An optical data detector array is used to optically determine the encoded address by comparing the signals with light levels and producing an output when a matching code is detected. The optical data detector array uses a series of detectors each corresponding to the wavelength of light signals carrying the information data.

Abstract: An artificial retina device and a method for stimulating and modulating its function is disclosed. The artificial retina device is comprised of plural multi-phasic microphotodiode subunits. In persons suffering from blindness due to outer retinal layer damage, a plurality of such devices, when surgically implanted into the subretinal space, may allow useful formed artificial vision to develop. One device, called a MMRI-4, transduces light into electric currents to stimulate the retina. The four microphotodiode subunits of the MMRI-4 are oriented so that each flattened sides of the MMRI-4 has two subunits in a PiN configuration and two subunits in a NiP configuration. The flattened cubic shape of the MMRI-4 will allow one or the other of the two flattened sides to be preferentially directed toward incident light when implanted in the subretinal space.

Abstract: An optical signal receiver for rapid and error free translation of optical signals into electrical signals is disclosed. The receiver is coupled to a light source. The light source is amplified and then split into two segments. One of the segments is delayed by a specific amount of time. Both segments are optically coupled to a photo detector. Each photo detector is coupled in parallel and are connected by two output terminals. When the voltage output by each photo detector is equal, the output terminals are balanced and will not have any voltage. The circuit will provide a voltage output on the terminal only on differential photocurrents sensed by the detector elements. The quiescent magnitude of the voltage output is a function of the value of the reverse bias voltage applied by the two voltage sources.

Abstract: Methods of using physical stimulation by itself or in conjunction with growth factors to treat and prevent visual loss due to choroidal, retinal pigment epithelial and/or neuroretinal cell degeneration and dysfunction are presented.

Abstract: Methods of using electrical stimulation by itself or in conjunction with growth factors to treat and prevent visual loss due to choroidal, retinal pigment epithelial and/or neuroretinal cell degeneration and dysfunction are presented.