Patents by Inventor Alaric Dyckman

Alaric Dyckman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PYRROLO-TRIAZINE ANILINE COMPOUNDS USEFUL AS KINASE INHIBITORS
    Publication number: 20110098467
    Abstract: Compounds having the formula (I), and pharmaceutically acceptable salts, prodrugs, and solvates thereof, are useful as kinase inhibitors, wherein R1, R2, R3, R4, R5, R6, X and Z are as described in the specification.
    Type: Application
    Filed: December 31, 2010
    Publication date: April 28, 2011
    Inventors: Alaric Dyckman, John Hynes, Katerina Leftheris, Chunjian Liu, Stephen T. Wrobleski
  • PYRROLO-TRIAZINE ANILINE COMPOUNDS USEFUL AS KINASE INHIBITORS
    Publication number: 20100240646
    Abstract: Compounds having the formula (I), and pharmaceutically acceptable salts, prodrugs, and solvates thereof, are useful as kinase inhibitors, wherein R1, R2, R3, R4, R5, R6, X and Z are as described in the specification.
    Type: Application
    Filed: June 3, 2010
    Publication date: September 23, 2010
    Inventors: Alaric Dyckman, John Hynes, Katerina Leftheris, Chunjian Liu, Stephen T. Wrobleski
  • Pyrrolo-triazine aniline compounds useful as kinase inhibitors
    Patent number: 7759343
    Abstract: Compounds having the formula (I), and pharmaceutically acceptable salts, prodrugs, and solvates thereof, are useful as kinase inhibitors, wherein R1, R2, R3, R4, R5, R6, X and Z are as described in the specification.
    Type: Grant
    Filed: October 28, 2008
    Date of Patent: July 20, 2010
    Assignee: Bristol-Myers Squibb Company
    Inventors: Alaric Dyckman, John Hynes, Katerina Leftheris, Chunjian Liu, Stephen T. Wrobleski
  • Pyrrolo-Triazine Aniline Compounds Useful As Kinase Inhibitors
    Publication number: 20090105243
    Abstract: Compounds having the formula (I), and pharmaceutically acceptable salts, prodrugs, and solvates thereof, are useful as kinase inhibitors, wherein R1, R2, R3, R4, R5, R6, X and Z are as described in the specification.
    Type: Application
    Filed: October 28, 2008
    Publication date: April 23, 2009
    Inventors: Alaric Dyckman, John Hynes, Katerina Leftheris, Chunjian Liu, Stephen T. Wrobleski
  • Imidazo-fused oxazolo [4,5-]pyridine and imidazo-fused thiazolo[4,5-]pyridine based tricyclic compounds and pharmaceutical compositions comprising same
    Patent number: 7456194
    Abstract: The present invention provides for pyrazolopurine-based tricyclic compounds having the formula (I), wherein R1, R2, R3, and R6 are as described herein. The present invention further provides pharmaceutical compositions comprising such compounds, as well as the use of such compounds for treating inflammatory and immune diseases.
    Type: Grant
    Filed: November 10, 2005
    Date of Patent: November 25, 2008
    Assignee: Bristol-Myers Squibb Company
    Inventors: Alaric Dyckman, William J. Pitts, Makonen Belema, Patrice Gill, James Kempson, Yuping Qiu, Claude Quesnelle, Steven H. Spergel, F. Christopher Zusi
  • PYRAZOLE-AMINE COMPOUNDS USEFUL AS KINASE INHIBITORS
    Publication number: 20080108626
    Abstract: The present invention provides pyrazole derived compounds of formula (I) useful for treating p38 kinase-associated conditions, where G, X, R1, R2, R3, R4, R5, R6 and m are as defined herein. The invention further pertains to pharmaceutical compositions containing at least one compound according to the invention useful for treating p38 kinase-associated conditions, and methods of inhibiting the activity of p38 kinase in a mammal.
    Type: Application
    Filed: October 31, 2007
    Publication date: May 8, 2008
    Inventors: Alaric Dyckman, Jagabandhu Das, Katerina Leftheris, Chunjian Liu, Robert Moquin, Stephen Wrobleski
  • PYRAZOLE-AMINE COMPOUNDS USEFUL AS KINASE INHIBITORS
    Publication number: 20080004278
    Abstract: The present invention provides pyrazole derived compounds of formula (I) useful for treating p38 kinase-associated conditions, where W, X, R1, R2, R3, R4, R5, R6 and m are as defined herein. The invention further pertains to pharmaceutical compositions containing at least one compound according to the invention useful for treating p38 kinase-associated conditions, and methods of inhibiting the activity of p38 kinase in a mammal.
    Type: Application
    Filed: August 2, 2007
    Publication date: January 3, 2008
    Inventors: Alaric Dyckman, Jagabandhu Das, Katerina Leftheris, Chunjian Liu, Robert Moquin, Stephen Wrobleski
  • Pyrrolo-triazine aniline compounds useful as kinase inhibitors
    Publication number: 20070043053
    Abstract: Compounds having the formula (I), and pharmaceutically acceptable salts, prodrugs, and solvates thereof, are useful as kinase inhibitors, wherein R1, R2, R3, R4, R5, R6, X and Z are as described in the specification.
    Type: Application
    Filed: October 24, 2006
    Publication date: February 22, 2007
    Inventors: Alaric Dyckman, John Hynes, Katerina Leftheris, Chunjian Liu, Stephen Wrobleski
  • Pyrrolo-triazine aniline compounds useful as kinase inhibitors
    Patent number: 7160883
    Abstract: Compounds having the formula (I), and pharmaceutically acceptable salts, prodrugs, and solvates thereof, are useful as kinase inhibitors, wherein R1, R2, R3, R4, R5, R6, X and Z are as described in the specification.
    Type: Grant
    Filed: April 22, 2003
    Date of Patent: January 9, 2007
    Assignee: Bristol-Myers-Squibb Company
    Inventors: Alaric Dyckman, John Hynes, Katerina Leftheris, Chunjian Liu, Stephen T. Wrobleski
  • Pyrazole-amine compounds useful as kinase inhibitors
    Publication number: 20060247247
    Abstract: The present invention provides pyrazole derived compounds of formula (I) useful for treating p38 kinase-associated conditions, where W, X, R1, R2, R3, R4, R5, R6 and m are as defined herein. The invention further pertains to pharmaceutical compositions containing at least one compound according to the invention useful for treating p38 kinase-associated conditions, and methods of inhibiting the activity of p38 kinase in a mammal.
    Type: Application
    Filed: June 28, 2006
    Publication date: November 2, 2006
    Inventors: Alaric Dyckman, Jagabandhu Das, Katerina Leftheris, Chunjian Liu, Robert Moquin, Stephen Wrobleski
  • Imidazo-fused oxazolo[4,5-b]pyridine and imidazo-fused thiazolo[4,5-b]pyridine based tricyclic compounds and pharmaceutical compositions comprising same
    Publication number: 20060106051
    Abstract: The present invention provides for pyrazolopurine-based tricyclic compounds having the formula (I), wherein R1, R2, R3, and R6 are as described herein. The present invention further provides pharmaceutical compositions comprising such compounds, as well as the use of such compounds for treating inflammatory and immune diseases.
    Type: Application
    Filed: November 10, 2005
    Publication date: May 18, 2006
    Inventors: Alaric Dyckman, William Pitts, Makonen Belema, Patrice Gill, James Kempson, Yuping Qiu, Claude Quesnelle, Steven Spergel, F. Zusi
  • N-heterocyclic inhibitors of TNF-alpha expression
    Publication number: 20050239770
    Abstract: N-heterocyclic compounds that block cytokine production via inhibition of p38 kinase are disclosed. In one embodiment, compounds of the present invention are represented by Formula I: Methods of production, pharmaceutical compositions and methods of treating conditions associated with inappropriate p38 kinase activity or TNF-? expression utilizing compounds of the present invention are also disclosed.
    Type: Application
    Filed: June 2, 2005
    Publication date: October 27, 2005
    Inventors: Kevin Moriarty, Yvonne Shimshock, Gulzar Ahmed, Junjun Wu, James Wen, Wei Li, Shawn Erickson, Jeffrey Letourneau, Edward McDonald, Katerina Leftheris, Stephen Wrobleski, Zahid Hussain, Ian Henderson, Axel Metzger, John Baldwin, Alaric Dyckman
  • Aryl-substituted pyrazole-amide compounds useful as kinase inhibitors
    Publication number: 20050159424
    Abstract: The present invention relates to compounds having the formula, and pharmaceutically-acceptable salts, prodrugs, solvates, isomers, and/or hydrates thereof, wherein Q is an optionally-substituted phenyl, pyridyl, pyridazinyl, pyrimidinyl, or pyrazinyl ring; R2 is alkyl or an amino group as defined herein; and Z is optionally-substituted oxadiazolyl or —C(?O)NR6, wherein R6 is lower alkyl or cyclopropyl. The compounds are surprisingly advantageous in preparing pharmaceutical compositions for treating p38 kinase related conditions and/or in methods of treating conditions associated with the activity of p38 kinase in a patient.
    Type: Application
    Filed: May 3, 2004
    Publication date: July 21, 2005
    Inventors: Alaric Dyckman, Jagabandhu Das, Katerina Leftheris, Chunjian Liu, Rulin Zhao, Bang-Chi Chen, Stephen Wrobleski
  • Methods for the preparation of pyrrolotriazine compounds useful as kinase inhibitors
    Publication number: 20050107462
    Abstract: Methods of preparing kinase inhibiting pharmaceutical compounds having the formula (I): or a pharmaceutically acceptable salt or solvate thereof, wherein R1 through R6 and Z are as described in the specification. The methods according to the invention utilize an amination process, in which a pyrrole is reacted with a haloamine, preferably chloramine. This step is followed by cyclization to form the pyrrolotriazine core.
    Type: Application
    Filed: December 22, 2004
    Publication date: May 19, 2005
    Inventors: Jollie Godfrey, John Hynes, Alaric Dyckman, Katerina Leftheris, Zhongping Shi, Stephen Wrobleski, Wendel William Doubleday, John Grosso
  • Heteroaryl-substituted pyrrolo-triazine compounds useful as kinase inhibitors
    Publication number: 20050043306
    Abstract: Compounds having the formula (I), and pharmaceutically acceptable salts, prodrugs, and solvates thereof, are useful as kinase inhibitors, wherein R1, R2, R3, R4, R5, R6, X and Z are as described in the specification.
    Type: Application
    Filed: October 3, 2003
    Publication date: February 24, 2005
    Inventors: Katerina Leftheris, Stephen Wrobleski, Alaric Dyckman
  • Pyrazole-amide compounds useful as kinase inhibitors
    Publication number: 20050004176
    Abstract: The present invention provides pyrazole derived compounds of formula (I) useful for treating p38 kinase-associated conditions, where G, X, R1, R2, R3, R4, R5, R6 and m are as defined herein. The invention further pertains to pharmaceutical compositions containing at least one compound according to the invention useful for treating p38 kinase-associated conditions, and methods of inhibiting the activity of p38 kinase in a mammal.
    Type: Application
    Filed: May 3, 2004
    Publication date: January 6, 2005
    Inventors: Alaric Dyckman, Jagabandhu Das, Katerina Leftheris, Chunjian Liu, Robert Moquin, Stephen Wrobleski
  • Pyrrolo-triazine aniline compounds useful as kinase inhibitors
    Publication number: 20040082582
    Abstract: Compounds having the formula (I), 1
    Type: Application
    Filed: April 22, 2003
    Publication date: April 29, 2004
    Inventors: Alaric Dyckman, John Hynes, Katerina Leftheris, Chunjian Liu, Stephen T. Wrobleski
  • Aryl ketone pyrrolo-triazine compounds useful as kinase inhibitors
    Publication number: 20030232831
    Abstract: Compounds having the formula (I), 1
    Type: Application
    Filed: April 22, 2003
    Publication date: December 18, 2003
    Inventors: Alaric Dyckman, Katerina Leftheris, John Hynes